Clinical significance of Beta-2 glycoprotein I antibodies in BcrAbl (-) myeloproliferative neoplasms

Küçük Resim Yok

Tarih

2017

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

ALLIED ACAD

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Background: Beta-2 glycoprotein I antibodies (B2-GPI Ab) are significant markers of thrombosis in otoimmune diseases. No literature has been found in Bcr Abl (-) MPNs to exclude the risk of hereditary thrombophilia and to investigate the association of B2-GPI Ab levels with thrombosis. This study aimed to investigate the relation between levels of B2-GPI Ab and thrombosis in BcrAbl (-) MPN without the risk of hereditary thrombophilia. Methods: Plasma samples from healthy volunteers and BcrAbl (-) MPN's patients with and without thrombosis were collected after receiving consent. B2-GPI Ab in plasma was quantified by enzyme-linked immunosorbent assay and the data were analyzed to determine whether plasma.2-GPI Ab correlates significantly with thrombosis. Result: There was a statistically significant difference between the B2-GPI Ab levels of the patients and the control group (p=0.006). However, no statistically significant difference in levels of B2-GPI between patients with and without thrombosis history was determined (p=0.144). Conclusion: This study supports that no relationship between levels of B2-GPI Ab and thrombosis complications in BcrAbl (-) MPN.

Açıklama

Anahtar Kelimeler

Myeloproliferative neoplasms, Policythaemia vera, Essential thrombocytosis, Beta-2 glycoprotein I antibody, Thrombosis

Kaynak

BIOMEDICAL RESEARCH-INDIA

WoS Q Değeri

N/A

Scopus Q Değeri

N/A

Cilt

28

Sayı

6

Künye