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Öğe The effect of systemically administrated zoledronic acid on the osseointegration of dental implants(WILEY, 2012) Ayan, M.; Dolanmaz, D.; Mihmanli, A.; Ayan, A.; Kurkcu, M.Oral Diseases (2012) 18, 802808 Objective: The aim of conducting this study was to evaluate the effect of zoledronic acid (ZA) on the new bone formation (NBF) after the insertion of a titanium dental implant, which is very popular treatment in dentistry. Study Design: Twelve New Zealand white rabbits were used in this study. The rabbits were divided in two groups. ZA was systemically administered to the study group. Titanium implants were placed to the left and right tibias of the rabbits. Results: The data from the ZA group revealed a statistically significant increase in the bone mineral content and the bone mineral density. A non-decalcified histomorphometric examination conducted on the study group revealed a significant increase of NBF and bone-implant contact (BIC) at 2 and 4 weeks. Conclusion: A single dose of systemic ZA administration increases the rate of NBF and augments the quality of the bone.Öğe Histomorphometric evaluation of delayed changes in masseter muscle after lengthening the rabbit mandible by distraction osteogenesis(WILEY, 2009) Tuez, H. H.; Dolanmaz, D.; Pampu, A. Alper; Kisnisci, R. S.; Guenhan, OeThe aim of the study was to evaluate the delayed responses and changes of gradually lengthened masseter muscles of rabbit mandibles. Unilateral lengthening of rabbit mandibles was performed in 18 New Zealand rabbits for 7 days at the rate of 1 mm day(-1). Mandibles of animals were removed at months 3, 4, and 6 after distraction. Biopsy samples of distracted and contralateral side masseter muscles were histopathologically evaluated and mean area of muscle fibers (MAF) was evaluated with histomorphometric methods. Results were statistically analyzed. Mild to moderate atrophy of the fibers, and necrosis and myophagocytosis in some areas were the leading features at month 3 and which were decreased at month 4 in distracted side-muscle specimens, with no statistically significant differences when compared with non-distracted side muscles at the same periods. Almost completely, normal fibers were detected in distracted muscle specimens at month 6. Evidence of myopathic changes was found to disappear at month 6 and no significant difference was found in the MAF of distracted side muscles. This study showed that the masseter muscle could adapt to gradual lengthening of the mandible within 6 months. Regenerative features and some degree of atrophic changes that could be observed at months 3 and 4 disappeared at month 6, with adaptation of the fibers.Öğe Monitoring bone morphogenetic protein-2 and-7, soluble receptor activator of nuclear factor-kappa B ligand and osteoprotegerin levels in the peri-implant sulcular fluid during the osseointegration of hydrophilic-modified sandblasted acid-etched and sandblasted acid-etched surface dental implants(WILEY-BLACKWELL, 2015) Dolanmaz, D.; Sağlam, M.; İnan, O.; Dündar, N.; Alnıaçık, Gamze; Trak, B. Gürsoy; Koçak, E.Background and ObjectiveThe implant surface plays a major role in the biological response to titanium dental implants. The aim of this study was to investigate levels of soluble receptor activator of nuclear factor-B ligand (sRANKL), osteoprotegerin (OPG), bone morphogenetic protein-2 (BMP-2) and -7 (BMP-7) in the peri-implant crevicular fluid (PICF) of different implants during the osseointegration period. Material and MethodsForty-seven patients (22 females and 25 males, mean age 47.3410.11) were included in this study. Forty-seven implants from two implant systems (group A1 (sandblasted acid-etched [SLA]-16), group A2 (hydrophilic-modified SLA [SLActive]-16), and group B (sandblasted acid-etched [SLA]-15) were placed using standard surgical protocols. PICF samples, plaque index, gingival index and probing depth measurements were obtained at 1 and 3mo after surgery. PICF levels of sRANKL, OPG, BMP-2/-7 were analyzed by ELISA. ResultsNo complications were observed during the healing period. No significant differences were observed in the PICF levels of sRANKL, OPG, BMP-2 and BMP-7 for all groups at any time point (p>0.05). A significant decrease was observed in BMP-2 levels in group A1 (p<0.05). A significant increase in BMP-7 levels was observed only for group A2 (p<0.05). There was a strong negative correlation between OPG and gingival index and a negative correlation between BMP-7 and plaque index (p<0.05). ConclusionConsidering the correlations between clinical and biochemical parameters, the levels of these cytokines in PICF during early healing of implants reflects the degree of peri-implant inflammation, rather than differences in the implant surfaces.Öğe Reconstruction of condyles by transport distraction osteogenesis: 3 case report with complication management(ELSEVIER SCIENCE BV, 2018) Dolanmaz, D.; Ozturk, K.; Ilik, M. B.; Celik, M.Objective: The aim of this case report is to evaluate the clinical outcomes that including minor postoperative complications of the transport distraction osteogenesis (TDO) for reconstruction of the ramus-condyle unit. Study design: We present 3 cases of the ramus-condyle unit reconstruction after the resection of bone tumors. All three bone tumors were excised intraoperatively and the histologic assessment confirmed the clinical diagnosis of osteochondroma, condylar hyperplasia, and osteoma. Results: Although postoperative minor complications were noted; all patients had satisfactory lateral and protrusive jaw movements, and also adequate mouth openings. Conclusion: TDO for reconstruction of the ramus-condyle unit is an effective treatment modality for TMJ reconstruction. However, after condylectomy with resection of the condylar neck, it seems to be a reliable approach to adjust the distraction vector slightly posterior to maintain the transport segment in glenoid fossa to prevent the premature contact of bony segments, especially for individuals who have shorter anteroposterior ramus length in the axial plane. (C) 2018 Elsevier Masson SAS. All rights reserved.Öğe An unusual size of ameloblastic fibro-odontoma(BRITISH INST RADIOLOGY, 2008) Dolanmaz, D.; Pampu, A. A.; Kalayci, A.; Etoz, O. A.; Atici, S.Ameloblastic fibro-odontoma (AFO) is a quite rare, mixed odontogenic tumour generally seen in the early stages of life. Frequent signs of the tumour are asymptomatic swelling, delayed tooth eruption and mixed radiological appearance within well-defined borders. Management of the lesion includes enucleation of the tumour and long-term follow-up in order to avoid recurrence. A 9-year-old girl was referred to our clinic with swelling in her right cheek. After clinical and radiographic examination, a large lobular radiopaque mass with a radiolucent border covering the complete right maxillary sinus was observed. Under general anaesthesia, the lobules of the lesion were enucleated and the permanent right lateral incisor and canine teeth were left for eruption. Histological assessment revealed a final diagnosis of ameloblastic fibro-odontoma. Post-operative healing was uneventful and the remaining teeth erupted normally. No recurrence was observed during the 3 years' follow-up period.