Monitoring bone morphogenetic protein-2 and-7, soluble receptor activator of nuclear factor-kappa B ligand and osteoprotegerin levels in the peri-implant sulcular fluid during the osseointegration of hydrophilic-modified sandblasted acid-etched and sandblasted acid-etched surface dental implants
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
WILEY-BLACKWELL
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background and ObjectiveThe implant surface plays a major role in the biological response to titanium dental implants. The aim of this study was to investigate levels of soluble receptor activator of nuclear factor-B ligand (sRANKL), osteoprotegerin (OPG), bone morphogenetic protein-2 (BMP-2) and -7 (BMP-7) in the peri-implant crevicular fluid (PICF) of different implants during the osseointegration period. Material and MethodsForty-seven patients (22 females and 25 males, mean age 47.3410.11) were included in this study. Forty-seven implants from two implant systems (group A1 (sandblasted acid-etched [SLA]-16), group A2 (hydrophilic-modified SLA [SLActive]-16), and group B (sandblasted acid-etched [SLA]-15) were placed using standard surgical protocols. PICF samples, plaque index, gingival index and probing depth measurements were obtained at 1 and 3mo after surgery. PICF levels of sRANKL, OPG, BMP-2/-7 were analyzed by ELISA. ResultsNo complications were observed during the healing period. No significant differences were observed in the PICF levels of sRANKL, OPG, BMP-2 and BMP-7 for all groups at any time point (p>0.05). A significant decrease was observed in BMP-2 levels in group A1 (p<0.05). A significant increase in BMP-7 levels was observed only for group A2 (p<0.05). There was a strong negative correlation between OPG and gingival index and a negative correlation between BMP-7 and plaque index (p<0.05). ConclusionConsidering the correlations between clinical and biochemical parameters, the levels of these cytokines in PICF during early healing of implants reflects the degree of peri-implant inflammation, rather than differences in the implant surfaces.
Açıklama
Anahtar Kelimeler
bone morphogenetic proteins, dental implant, osteoprotegerin, receptor activator of nuclear factor-kappa B
Kaynak
JOURNAL OF PERIODONTAL RESEARCH
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
50
Sayı
1
