Monitoring bone morphogenetic protein-2 and-7, soluble receptor activator of nuclear factor-kappa B ligand and osteoprotegerin levels in the peri-implant sulcular fluid during the osseointegration of hydrophilic-modified sandblasted acid-etched and sandblasted acid-etched surface dental implants

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dc.contributor.authorDolanmaz, D.
dc.contributor.authorSağlam, M.
dc.contributor.authorİnan, O.
dc.contributor.authorDündar, N.
dc.contributor.authorAlnıaçık, Gamze
dc.contributor.authorTrak, B. Gürsoy
dc.contributor.authorKoçak, E.
dc.date.accessioned2020-03-26T19:06:22Z
dc.date.available2020-03-26T19:06:22Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and ObjectiveThe implant surface plays a major role in the biological response to titanium dental implants. The aim of this study was to investigate levels of soluble receptor activator of nuclear factor-B ligand (sRANKL), osteoprotegerin (OPG), bone morphogenetic protein-2 (BMP-2) and -7 (BMP-7) in the peri-implant crevicular fluid (PICF) of different implants during the osseointegration period. Material and MethodsForty-seven patients (22 females and 25 males, mean age 47.3410.11) were included in this study. Forty-seven implants from two implant systems (group A1 (sandblasted acid-etched [SLA]-16), group A2 (hydrophilic-modified SLA [SLActive]-16), and group B (sandblasted acid-etched [SLA]-15) were placed using standard surgical protocols. PICF samples, plaque index, gingival index and probing depth measurements were obtained at 1 and 3mo after surgery. PICF levels of sRANKL, OPG, BMP-2/-7 were analyzed by ELISA. ResultsNo complications were observed during the healing period. No significant differences were observed in the PICF levels of sRANKL, OPG, BMP-2 and BMP-7 for all groups at any time point (p>0.05). A significant decrease was observed in BMP-2 levels in group A1 (p<0.05). A significant increase in BMP-7 levels was observed only for group A2 (p<0.05). There was a strong negative correlation between OPG and gingival index and a negative correlation between BMP-7 and plaque index (p<0.05). ConclusionConsidering the correlations between clinical and biochemical parameters, the levels of these cytokines in PICF during early healing of implants reflects the degree of peri-implant inflammation, rather than differences in the implant surfaces.en_US
dc.description.sponsorshipResearch Project Coordination of Selcuk UniversitySelcuk University [08401093]en_US
dc.description.sponsorshipThis study was supported by the Research Project Coordination of Selcuk University (project no. 08401093). The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article. The authors are grateful to Bulent Ozkan (Department of Biostatistics, Izmir Katip Celebi University) for his help in statistical analyses.en_US
dc.identifier.doi10.1111/jre.12182en_US
dc.identifier.endpage73en_US
dc.identifier.issn0022-3484en_US
dc.identifier.issn1600-0765en_US
dc.identifier.issue1en_US
dc.identifier.pmid24697526en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage62en_US
dc.identifier.urihttps://dx.doi.org/10.1111/jre.12182
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32335
dc.identifier.volume50en_US
dc.identifier.wosWOS:000347467600008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofJOURNAL OF PERIODONTAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectbone morphogenetic proteinsen_US
dc.subjectdental implanten_US
dc.subjectosteoprotegerinen_US
dc.subjectreceptor activator of nuclear factor-kappa Ben_US
dc.titleMonitoring bone morphogenetic protein-2 and-7, soluble receptor activator of nuclear factor-kappa B ligand and osteoprotegerin levels in the peri-implant sulcular fluid during the osseointegration of hydrophilic-modified sandblasted acid-etched and sandblasted acid-etched surface dental implantsen_US
dc.typeArticleen_US

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