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Öğe Akciğer surfaktan sistemi(1997) Durgun, Zafer; Keskin, ErcanPulmoner surfaktanlar tip II alveoler epiteliyal hücrelerce salgılanan, alveol ve küçük havayollarını kaplayan bir fosfolipid ve protein kompleksidir. Surfaktanların bilinen fonksiyonları (1) alveol duvarını uygun bir nemlilikte tutmak; (2) pasif ekspirasyon esnasında daha kolay elastik büzülme için sabit esansiyel bir faktör olarak rol oynamak; (3) hava-sıvı tabakasında yüzey gerilimini azaltarak alveollerin stabilizasyonunu sağlamak ya da ekspirasyon esnasında küçük alveollerin kollapsmı ve daha büyük alveollere yapışmasını önlemek; (4) kapiller ve interstisyel sıvıların alveolier içerisine infiltrasyonuna karşı direnç oluşturmak; ve (5) inhalasyon sonucu alveollere kadar ulaşabilecek küçük partiküllerin emülsifiye edilmesini sağlayarak bunların makrofajlar tarafından fagositozunu kolaylaştırmaktır. Surfaktan yetersizliği ya da kompozisyonundaki farklılıkların prenatal ve neonatal dönemde yetersiz akciğer gelişimi ve yetişkinlerin birçok pulmoner hastalığı ile ilgili olduğu bildirilmektedir. Bu nedenle surfaktanların bu hastalıklardaki rolü ve terapötik nitelikleri ile ilgili olarak birçok araştırma yapılmakta ve her geçen gün yeni bilgiler elde edilmektedir.Öğe Akkaraman Kuzularda Defaunasyonun Uçucu Yağ Asi?tleri? Üzeri?ndeki? Etki?si?(Selçuk Üniversitesi, 1988 Ocak) Kocabatmaz, Mehmet; Aksoylar, M. Yaşar; Durgun, Zafer; Eksen, MursayettinTwo groups of Akkaraman lambs (faunated and defaunated lambs) were used to investigate the effect of the presence or absence of rumen ciliate protozoa on pH, volatile fatty acids of rumen content and weight gain. The lambs were fed with milk until 1.5 months of age. Then, all animals were given chopped sainfoin hay and concentrate diet for the duration of the experiment. For the purpose of defaunation of the 2nd group lambs, 0.3-0.8 % solution of Dioctyl Sodium Sulfosuccinate was administrated via stomach tube. Rumen samples were taken from the rumen of lambs before feeding and at 3, 6 hr. after feeding and pH values and volatile fatty acids levels were measured. pH values were found to be highest before feeding, decreased at the 3rd hr. and became lowest at the 6th. after feeding for each animals. Acetic acid, propionic acid, iso-butiric acid and total volatile fatty acid levels in the rumen contents of the faunated lambs were higher than in the defaunated lambs. The faunated lambs grew faster that the defaunated lambs. The average of body weights of the faunated lambs was 4.6 kg more than the faunated lambs It was, therefore, concluted that the rumen ciliate protozoa are essential for the metabolism and growth of young lambs.Öğe Ankara Keçi?leri?ni?n Rumen ve Kan Metaboli?tleri? Üzeri?nde Fosforun Etki?si?(Selçuk Üniversitesi, 1992 Ocak) Kocabatmaz, Mehmet; Eksen, Mursayettin; Durgun, ZaferIn this investigation, three Angora Goats of 3 years old and with the permanent rumen cannula were used. The goats were fed with alfalfa hay (40%) and the pelleted white beet pulp (60%). The first animal was used as a control and 1 g and 2.4 g phosphorus were infused via rumen cannula into rumen of the second and third animals respectively. Rumen content and blood samples were taken before feeding and at the 3rd and 6th hour after feeding with 7 days intervals. The pH values of rumen contents were highest before feeding and generally lowest at 6th hour after feeding for all animals. At the each sampling time, the average values of protozoa counts and percentage of Isotricha intestinalis, Isotricha prostoma and Dasytricha ruminantium for second and third animals to which phosphorus (Ig and 2.4 g respectively) infused were highest than first animal but the percentage of Entodinium minimum and Entodinium caudatum showed decrements for second and third animals. On the other hand, the highest NH3 - N values of rumen contents were determined for the second animal at each sampwling time but same values were lowest for first animal. Before feeding, urea-N of blood was highest and showed gradually decrements after feeding for first animal. The same values were found to be lowest before feeding, and showed increments for second animal at other sampling times. All of the total protein values generally were equal for all animals. The glucose values of blood sera belongig to the third animal were found higher than the other animals only the lower values of glucose at the before feeding showed gradually incaremets after feeding for all animals. In addition before of the effect of phosphate infusion, inorganic phosphorus values of rumen contents and blood sera of the second and third animals were higher than the first animal at each sampling time.Öğe Ankara Keçi?leri?ni?n Rumeni?ndeki? Si?li?alı Protozoonların Geli?şmesi?nde Farklı Rasyonların Etki?si?(Selçuk Üniversitesi, 1988 Ocak) Kocabatmaz, Mehmet; Eksen, Mursayettin; Durgun, ZaferIn this investigation pH values, protozoa counts, protozoa volumes and protozoa species were determined in the rumen contents of Angora goats fed with different rations. For this purpose 4 animals with 2 years old and with permanent rumen cannula were used. Feeding the animals was performed according to 4 x 4 Latin Square desing. Each animal was fed with four different types of rations (I, II, III, IV); alfalfa straw (100 %), alfalfa straw + concentrate mixture (80: 20, 60 40, 40: 60) respectively. pH value of rumen content was found to be highest (7.22) before feeding, but dropped to 6.21 at the 6 th hour and incereased again (6.42) at the 10 th hour following the feeding. The protozoa counts and their volumes of rumen contents showed a paralelism to the declination in pH values. Total 10 protozooon species were identified, but "Entodinium minimum" was predominant at each sampling time. The differences between pH values and protozoa counts were generally found to be higly significant (p<0,01). The protozoon counts and their volumes were higher for the animals fed IV th ration than for the animals having the other rations.Öğe Ankara Keçi?si?ni?n Rumen Sıvısı ve Kanında Bazı Metaboli?tleri?n Değerleri?(Selçuk Üniversitesi, 1988 Ocak) Kocabatmaz, Mehmet; Eksen, Mursayettin; Durgun, ZaferThree Angora Goats of 2-2.5 years old, with permanent rumen cannula were used in this experiment. Animals were fed with three different types of rations with concentrate mixture and alfalfa straw; 20:80, 40: 60, 60:40 respectively. In the investigation; pH Inorganic P and NH3-N values in the rumen fluid and NH3N in the blood and Urea-N, total protein, glucose, Inorganic P levels in the blood sera vere determined before feeding, at the 4 and 8th hour after feeding for each animal. At the 4 th hour after feeding the pH values in the rumen fluid and NH3-N of the blood were both decreased. The NH3-N values of the blood at the 8th hour after feeding and NH3-N levels of the rumen fluid at the 4th hour after feeding were highest. Inorganic P values in the blood sera were gradually increased but Inorganic P levels in the rumen fluid were decreased at the sampling times. No notable changes were observed in each sampling, as far as Urea-N, total protein and glucose levels of the blood sera are concerned.Öğe Ankara Keçilerinde Rasyona Çinko İlavesinin Plazma ve Eri?trosi?t Membranı Bazı Lipid Parametreleri? Üzeri?ne Etki?leri?(Selçuk Üniversitesi, 1999) Keskin, Ercan; Durgun, Zafer; Çöl, Ramazan; Dönmez, Nurcan; İpek, HüdaiIn the study, healthy and adult, 12 Angora goats were used. The animals were divided equally into two groups Group 1 (Control) and Group 2 (Zn Group) were fed ad libitum with a basal ration and the basal ration supplemented with 250 ppm Zn for 3 months. In the Zn group, plasma Zn levels were found to be significantly (P < 0.05) hig- her than those in the Control group at the all sampling times. While plasma Cholesterol level in the Zn group were found to be higher than Control group during the study, the difference in the month 3 was important (P < 0.05) Plasma HDL-C(High density Lipoprotein Cholesterol) levels did not show any differences between groups during the study Plasma phospholipid levels of Zn group were significantly (P < 0.05) higher than in Control group in the month 2. 3. Ho- wever Erythrocyte membrane phospholipid levels were generally higher in Zn group as compared with Control group and the difference lonely in the month 2 was important (P<0.05) On the other hand, erythrocyte membrane cho- lesterol levels were found to be slightly higher in the Zn group unless different from those in Control group. Consequently, the Zn supplementation in Angora goats seems striking in respect of the changes in plasma and eryt hrocyte membrane lipid fractions, because of the important roles of phospholipids and cholesterol on dynamics and structure of these cells.Öğe Aspi?ri?n ve Sarımsak Veri?len Deneysel Hiperkolesterolemi?li? Tavşanlarda Bazı Elektrokardi?yografi?k Parametreler(Selçuk Üniversitesi, 1999) Keskin, Ercan; Durgun, Zafer; Çöl, RamazanIn the study, the effects of aspirin and garlic powder supplementation on some electrocardiographic pa- rameters in hypercholesterolaemic rabbits were investigated. Although the plasma cholesterol-rich ration for 4 weeks significantly (p < 0.05) increased as compared with the control group, the plasma cholesterol levels in the group supplemented with garlic powder was found to be significantly lower than in both the group received the cholesterol-rich ration alone and the group fed the ration with aspirin (p < 0.05) The heart rates in the control group (252.7) and in the groups supplemented with garlic (286.0), aspirin (271.7) and lonely cholesterol (276.3) were not significantly dif ferent from each other. The duration and voltages of P. QRS and T waves measured in lead II and the durations of P Q and Q-T intervals in the same lead showed no significant difference between groups. It was not also determined any changes in respect of the shape and position of the waves in all leads of the treatments as compared those in the control group.Öğe Broyler Pi?li?çleri?nde Si?tri?k Asi?di?n Klortetrasi?kli?ni?n Si?ndi?ri?m Si?stemi?nden Emi?lmesi?ne Etki?si?(Selçuk Üniversitesi, 1987 Ocak) Acet, Ahmet; Eksen, Mursayettin; Durgun, ZaferPlasma and tissues concentrations were determined by fluorimetric method, after administering the chlortetracycline orally to the Broiler chickens. It was found that the most drug residues were in the liver and kidney. It was observed that citric acid has increased the chlortetracycline absorption in the alimentary tract. The emission maxima of the chlortetracycline was 500 nm and excitation maxima was at 400 nm. The chlortetracycline residues which were determined in the plasma and tissues were observed between 0,007-0,046 µg/g.Öğe Büyümekte Olan Erkek ve Di?şi? Japon Bıldırcılarında Bazı Hematoloji?k Parametreleri?n Seyri? Üzeri?ne Bi?r Çalışma(Selçuk Üniversitesi, 1995 Nisan) Keskin, Ercan; Durgun, Zafer; Kocabatmaz, MehmetThe aim of this work was to evaluate some haematological parameters in growing male and female quails. Thirty five male and 35 female, 1 to 8 week-aged Japanese quails were used in this study. Haematological examination were carried out in 5 male and 5 female quails at 1 st, 2 nd, 3 rd 4 th, 5 th, 6 th and 8 th week of ages The red blood cell (RBC) counts, haemoglobine amounts (Hb) and hematocrit values (PCV)) in both groups increased significantly with increased age (P<0.05). The RBC, Hb and PCV were found higher in male than female in all the age periods. The RBC was significantly higher in males (3.65x 106) than females (3.28x 106) at 8 week of age (P<0.05). The white blood cell (WBC) and thrombocyte counts did not show evidently changes, whereas WBC in females (2428x 103) were found slightly higher than males (21-26 x 10³) at all weeks. In the percentage of leucocyte types were not determined any differences between sexes during eight weeks and the lymphocyte percentages (57-70%) were drastically higher than heterophils (24-36 %) in both groups. There was no differences between sexes in respect to the blood cell sizes where as RBC sizes were bigger in females than males at either 1 st and 8 th weeks. On the other hand, in sizes of thrombocyte and leucocyte types in both groups were not determined differences between 1 st and 8 th weeks, but RBC sizes at 8 th week in both groups decreased significantly as compared with 1st week (P<0.05). Plasma glucose, cholesterol and total protein levels in both sexes increased gradually until 8 th week and plasma glucose level in males and plasma total protein level in female were higher, without differences between sexes in all ages.Öğe Büyümekte Olan Erkek ve Di?şi? Japon Bıldırcınlarında Bazı Hematoloji?k Parametreleri?n Seyri? Üzeri?ne Bi?r Çalışma(Selçuk Üniversitesi, 1995 Ocak) Keskin, Ercan; Durgun, Zafer; Kocabatmaz, MehmetThe aim of this work was to evaluate some haematological parameters in growing male and female quails. Thirty five male and 35 female, 1 to 8 week-aged Japanese quails were used in this study. Haematological examination were carried out in 5 male and 5 female quails at 1 st, 2 nd, 3 rd 4 th, 5 th, 6 th and 8 th week of ages The red blood cell (RBC) counts, haemoglobine amounts (Hb) and hematocrit values (PCV)) in both groups increased significantly with increased age (P< 0.05). The RBC, Hb and PCV were found higher in male than female in all the age periods. The RBC was significantly higher in males (3.65x 100) than females (3.28x 100) at 8 week of age (P<0.05). The white blood cell (WBC) and thrombocyte counts did not show evidently changes, whereas WBC in females (24-28x 103) were found slightly higher than males (21-26 x 103) at all weeks, In the percentage of leucocyte types were not determined any differences between sexes during eight weeks and the lymphocyte percentages (57-70%) were drastically higher than hleterophils (24-36%) in both groups. There was no differences between sexes in respect to the blood cell sizes where as RBC sizes were bigger in females than males at either 1 st and 8 th weeks. On the other hand, in sizes of thrombocyte and leucocyte types in both groups were not determined differences between 1 st and 8 th weeks, but RBC sizes at 8 th week in both groups decreased significantly as compared with 1st week (P<0.05). Plasma glucose, cholesterol and total protein levels in both sexes increased gradually until 8 th week and plasma glucose level in males and plasma total protein level in female were higher, without differences between sexes in all ages (P>0.05).Öğe Çesitli anyonlarin bildircinlarda kan asit-baz dengesi ve büyüme üzerine etkisi(1997) Durgun, Zafer; Keskın, Ercan; Kocabatmaz, Mehmet; Keçecı, Tufan[Abstract not Available]Öğe Çevre Isısı ve Vitamin C' nin I?sviçre Esmeri Boğalarda Kan Serumu Tiroid Hormon Düzeyleri ile Bazı Hematolojik Değerler Üzerindeki Etkileri(2000) Keçeci, Tufan; Keskin, Ercan; Durgun, ZaferBu çalışma İsviçre Esmeri boğalarda, farklı çevre ısılarının ve vitamin C uygulanmasının; serum tiroit hormon düzeylerine, bazı hematolojik değerlere, solunum hızına (SH), nabız hızına (NH) ve rektal ısıya (RI) etkilerini belirlenek için yapıldı. Bu amaçla, çalışmada toplam 84 sağlıklı hayvan kullanıldı. Bir yıl boyunca 2 ay aralıklarla, aynı bakım ve beslenme şartlarında olan boğalara 50 ml/hafta miktarında %20 oranında askorbik asit içeren vitamin C solüsyonu (n:7) ve aynı miktarda steril serum fizyolojik (n:7) kas İçi olarak 4 hafta süreyle enjekte edildi. Ayni periyotlarda, kan örnekleri alındı, hayvanların SH, NH ve RI değerleri ölçüldü, çevre ısısı verileri kaydedildi. Soğuk çevre ısılarındaki (3.2°C; %63.3 nispî nem(NN) ve/veya 5.3°C; %77.0 NN) miktarları ile karşılaştırıldığında, sıcak çevre ısılarında (20.8°C; 9639.3 NN ve/veya 23.7°C; %20.0 NN) boğalarda belirlenen serum toplam tiroksin, toplam triiyodotironin, serbest tiroksin, serbest triiyodotironin ve tiroit stimüle edici hormon düzeylerinin, alyuvar sayılarının, hemoglobin (Hb) miktarlarının ve hematokrit değerlerinin daha düşük düzeylerde olduğu bulundu. Buna karşın, soğuk çevre ısılarında hayvanların 1. ve 2. saatlerdeki sedimantasyon hızlarının, akyuvar sayılarının, SH, NH ve Ri düzeylerinin sıcak çevre ısılarındaki değerlerinden daha düşük miktarlarda olduğu belirlendi. Sıcak çevre isısında (20.8°C; %39.3 NN) azalan Hb miktarı vitamin C uygulanması ile arttı. Ancak, çalışmada incelenen diğer parametreler üzerine vitamin C uygulamasının önemli bir etkisi olmadı. Sonuç olarak, bu çalışmadaki çevre ısılarının İsviçre Esmeri sığırlarda incelenen parametre değerlerinde değişikliğe neden olduğu ve Hb miktarı haricinde değişen parametre değerlerinin düzeltilmesinde vitamin C'nin etkili bir madde olmadığı belirlendi.Öğe Çevre Isısı ve Vitamin C'nin İsviçre Esmeri Boğalarda Kan Serumu Tiroit Hormon Düzeyleri ile Bazı Hematolojik Değerler Üzerindeki Etkileri(2000) Keçeci, Tufan; Keskin, Ercan; Durgun, ZaferThe present study was carried out to investigate the effect of different environmental temperatures and vitamin C administration on the levels of serum thyroid hormones, some haematological values, respiration rate (RR), pulse rate (PR) and rectal temperature (RT) in Swiss Brown bulls. For this purpose, a total of 84 healthy animals were used in the experiment. At two month intervals during one year, the amount of 50 ml/week vitamin C solution containing 20% ascorbic acid (n:7) and the same amount of sterile physiological saline (n:7) were intramuscularly injected into the bulls, which were at the same conditions of maintenance and nutrition, within 4 weeks. During the same period, samples of blood were taken RR, PR and RT levels of the animals were measured and the data of environmental temperatures were recorded. The levels of serum total thyroxine, total triiodothyronine, free thyroxine, free triiodothyronine and thyroid stimulating hormone, erythrocyte counts, haemoglobin (Hb) amounts and haematocrit values in the bulls were found to be at lower levels in high environmental temperatures (20.8°C; 39.3% relative humidity (RH) and/or 23.7°C; 20.0% RH) than in low environmental temperatures (3.2°C; 63.3% RH and/or 5.3°C; 77.0% RH). although erythrocyte sedimentation rate after 1 and 2 hours, leukocyte counts, the amounts of RR, PR and RT in the animals in the low environmental temperatures were lower than those in the high environmental temperatures. Decreased Hb amount caused by the high ambient temperature (20.8°C; 39.3% RH) was increased by vitamin C administration. However, vitamin C did not have any significant influence on the other parameters that were examined in this study. Based on the results, it was determined that the different environmental temperatures caused some parameters investigated in Swiss Brown cattle to change and vitamin C was not an effective agent in restoring those parameters, except Hb.Öğe Çevre Isısı ve Vitamin C’nin İsviçre Esmeri Boğalarda Kan Serumu Tiroit Hormon Düzeyleri ile Bazı Hematolojik Değerler Üzerindeki Etkileri(Scientific Technical Research Council Turkey, 2000) Keçeci, Tufan; Keskin, Ercan; Durgun, ZaferBu çalışma İsviçre Esmeri boğalarda, farklı çevre ısılarının ve vitamin C uygulanmasının; serum tiroit hormon düzeylerine, bazı hematolojik değerlere, solunum hızına (SH), nabız hızına (NH) ve rektal ısıya (RI) etkilerini belirlemek için yapıldı. Bu amaçla, çalışmada toplam 84 sağlıklı hayvan kullanıldı. Bir yıl boyunca 2 ay aralıklarla, aynı bakım ve beslenme şartlarında olan boğalara 50 ml/hafta miktarında %20 oranında askorbik asit içeren vitamin C solüsyonu (n:7) ve aynı miktarda steril serum fizyolojik (n:7) kas içi olarak 4 hafta süreyle enjekte edildi. Aynı periyotlarda, kan örnekleri alındı, hayvanların SH, NH ve RI değerleri ölçüldü, çevre ısısı verileri kaydedildi. Soğuk çevre ısılarındaki (3.2°C; %63.3 nispi nem(NN) ve/veya 5.3°C; %77.0 NN) miktarları ile karşılaştırıldığında, sıcak çevre ısılarında (20.8°C; %39.3 NN ve/veya 23.7°C; %20.0 NN) boğalarda belirlenen serum toplam tiroksin, toplam triiyodotironin, serbest tiroksin, serbest triiyodotironin ve tiroit stinüle edici hormon düzeylerinin, alyuvar sayılarının, hemoglobin (Hb) miktarlarının ve hematokrit değerlerinin daha düşük düzeylerde olduğu bulundu. Buna karşın, soğuk çevre ısılarında hayvanların 1. ve 2. saatlerdeki sedimantasyon hızlarının, akyuvar sayılarının, SH, NH ve RI düzeylerinin sıcak çevre ısılarındaki değerlerinden daha düşük miktarlarda olduğu belirlendi. Sıcak çevre ısısında (20.8°C; %39.3 NN) azalan Hb miktarı vitamin C uygulanması ile arttı. Ancak, çalışmada incelenen diğer parametreler üzerine vitamin C uygulamasının önemli bir etkisi olmadı. Sonuç olarak, bu çalışmadaki çevre ısılarının İsviçre Esmeri sığırlarda incelenen parametre değerlerinde değişikliğe neden olduğu ve Hb miktarı haricinde değişen parametre değerlerinin düzeltilmesinde vitamin C'nin etkili bir madde olmadığı belirlendi.Öğe The Changes Associated With Fasting and Acute Heat Stress on Body Temperature, Blood Acid-base Balance and Some Parameters of Japanese Quail(1998) Durgun, Zafer; Keskin, Ercan[Abstract not Available]Öğe Deneysel Hi?perkolesterolemi? Oluşturulan Köpeklerde Bazı Hematoloji?k Parametreler Üzeri?ne Soğan Yağının Etki?si?(Selçuk Üniversitesi, 1995 Ocak) Keskin, Ercan; Durgun, Zafer; Kocabatmaz, Mehmet; Eryavuz, AbdullahEight dogs, 8-10 months aged, were used in the investigation. The dogs were divided into two equal groups as control and experimental. Both groups were fed diet containing 0.2% cholesterol for 16 days. At 10 th. day of this period, plasma cholesterol levels were increased four times to begining of this period in both groups. The increases in cholesterol levels in both groups caused no roughness in erytrocytes surface. After 10 th day of 16 day period, experimental group received daily 50µl of onion oil with 200 g of ground meat additon to cholesterol-supplemented diet whereas control group continued feeding cholesterol-suplemented diet and 200 g of ground meat for six days. At the 5 th. and 6 th. days of period of onion oil administration (15 th. and 16 th. days of total period). Plasma cholesterol levels in experimental group decreased slightly higher than control group and before onion oil administation, while plasma glucose level decreased significantly as compared to before onion oil administration and the same sampling time of control group (P<0,05). In the study, before and after hypercholesterolemia and after onion oil administration, it was not determined striking changes in respect of erythrocytes, leucocytes counts, haemoglobine amount and haematocrit values in both groups and between groups.Öğe Deneysel Hiperkolesterolemi Oluşturulan Köpeklerde Bazı Hematoloji?k Parametreler Üzeri?ne Soğan Yağının Etki?si?(Selçuk Üniversitesi, 1995 Nisan) Keskin, Ercan; Durgun, Zafer; Kocabatmaz, Mehmet; Eryavuz, AbdullahEight dogs, 8-10 months aged, were used in the investigation. The dogs were divided into two equal groups as control and experimental. Both groups were fed diet containing 0.2% cholesterol for 16 days. At 10 th. day of this period, plasma cholesterol levels were incereased four times to begining of this period in both groups. The increases in cholesterol levels in both groups caused no roughness in erytrocytes surface. After 10 th. day of 16 day period, experimental group received daily 50?l of onion oil with 200 g of ground meat additon to cholesterol-supplemented diet whereas control group continued feeding cholesterol-suplemented diet and 200 g of ground meat for six days. At the 5 th. and 6 th. days of period of onion oil administration (15 th. and 16 th. days of total period). Plasma cholesterol levels in experimental group decreased slightly higher than control group and before onion oil administation, while plasma glucose level decreased significantly as compared to before onion oil administration and the same sampling time of control group (P<0,05). In the study, before and after hypercholesterolemia and after onion oil administration, it was not determined striking changes in respect of erythrocytes, leucocytes counts, haemoglobine amount and haematocrit values in both groups and between groups.Öğe Di?rofi?lari?a I?mmi?ti?s ile Enfekte Köpeklerde Tedavi?ni?n Hematoloji?k Değerler Üzeri?ne Etki?si?(Selçuk Üniversitesi, 1992 Mart) Eksen, Mursayettin; Durgun, Zafer; Dik, Bilal; Keskin, ErcanIn this study, 13 German Wolfdogs, aged 6-11 years old, were used. Two of the dogs were not infected with D. immitis (Group I). Four of the infected dogs and seven of the infected dogs were assigned as positive control group (Group II) and treatment group (Group III), respectively. At the beginning of the experiment, Levamisole (2.5 mg/ kg, orally) was given to seven dogs (Treatment Group-Group III) for 14 days. The treatment was repeated at the 30 th day of the experiment (5 mg/kg, orally). At the 35th day of experiment, Ivermectin (0.2 mg/kg, orally) was given to treatment group for 5 days. Blood samples were taken at the beginning, 40 th and 70 th days of the experiment. At the beginning of the study, the mean values of RBC, WBC, haematocrit and hemoglobin in the infected dogs were found to be 6.57x106, 5.57x103, 48.33% and 15.46 g/dl, respectively. But these parameters in the healthy dogs were found to be 6.43x106 5.23x103, 40.67% and 13.26 g/dl, respectively. The lymphocytes, monocytes, mature neutrophils and eosinophils were determined to be 11.33%, 3.00%, 73,67% and 12.00% in the infected dogs, where as these values were found to be 11.50%, 2.50%, 78.00% and 8.00% in the healthy dogs, respectively. After the treatment, the mean values of RBC, WBC, haematocrit and hemoglobin in the second group were found to be 5.28x106,5.08x103, 42.00% and 16.24 g/dl, respectively. But these parameters in the third group were found to be 5.24x106, 6.34x103, 45.57% and 16.11 g/dl, despectively. On the other hand, the lymphocytes, monocytes, mature neutrophils and eosinophils were determined as 16.50%, 2.50%, 73.75% and 7.25% in the second group, where as these values found to be 14.28%, 2.21%, 75.00% and 8.51% in the third group, respectively. One month after treatment, the red blood cell counts in the third group were found to be higher than other groups. Increasing in the other blood parameters were not significant.Öğe EFFECT OF RECOMBINANT INTERLEUKIN-10 ON SOME HAEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN A RAT ENDOTOXAEMIC MODEL(AKADEMIAI KIADO RT, 2011) Col, Ramazan; Durgun, ZaferRecombinant interleukin-10 (rIL10) has been found to suppress the synthesis of tumour necrosis factor (TNF), interleukin-1 (IL-1), interleukin-6 (IL-6) and tissue factor and to improve survival from experimental sepsis. The aim of this study was to evaluate the protective effect of rIL-10 on lipopolysaccharide( LPS-) induced haematological and biochemical disturbances in rats. In the present study, 40 rats were used and divided equally into four groups. Group 1 (control group, C) was treated with 0.9% saline. Group 2: LPS was injected intravenously (1.6 mg/100 g), Group 3 received rIL10 treatment (125 mu g/kg) 2 min before 0.9% saline injection, Group 4 received rIL10 treatment 2 min before endotoxin treatment. When compared with the controls, platelet count, leukocyte count (with a marked neutrophilia and lymphopenia) and fibrinogen were decreased, while activated partial thromboplastin time (APTT) and prothrombin time (PT) were prolonged in the endotoxaemic rats. In addition, LPS caused statistically significant increases in plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities as well as creatinine, cholesterol and triglyceride concentrations, while it caused a statistically significant decrease in glucose, total protein and albumin levels as compared to the control group. On the other hand, rIL10 significantly suppressed disturbances in the haematological and biochemical parameters associated with endotoxaemia. As a result, rIL10 may be efficacious in preventing haematological disorders, tissue damage and changes in lipid, protein and carbohydrate metabolism in endotoxaemia.Öğe EFFECT OF VASOACTIVE INTESTINAL PEPTIDE (VIP) ON CYTOKINE LEVELS AND HAEMOSTATIC AND BIOCHEMICAL PARAMETERS IN A RAT ENDOTOXAEMIC MODEL(NATL VETERINARY RESEARCH INST, 2012) Col, Ramazan; Durgun, ZaferThe presented study was planned to determine whether vasoactive intestinal peptide (VIP) could prevent cytokine haemostatic, haematological, and biochemical disturbances in LPS-treated rats. Adult male Wistar rats (weight range: 200-250 g) were used. The study included four groups: group 1 served as a control group (C); animals in group 2 were given intravenously 1.6 mg/100 g of LPS (E. coli, serotype 0.111:B4); in group 3, rats were injected intraperitoneally with 25 ng/kg of VIP; in group 4, the same doses of VIP and I,PS were injected simultaneously. Blood samples were collected 6 h after treatments. In endotoxaemic rats, platelet count, fibrinogen, and antithrombin levels were decreased, the activated partial thromboplastin time and prothrombin time were prolonged, and leucopoenia, as well as significant changes in differential leukocyte percentage were demonstrated. In addition, LPS caused statistically significant increases in plasma INF-alpha, IL-6, and IL-10 levels, and AST, ALT, creatinine, cholesterol, triglyceride concentrations. However, it caused a statistically significant decrease in total protein and albumin levels when compared to control group. The results showed that during endotoxaemia, VIP had moderately therapeutic effect as an antiinflammatory agent, suppressing INF-alpha and IL-6, and stimulating IL-10; however, it was not effective against the adverse effect of LPS on investigated haematological and biochemical parameters.
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