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Öğe Acrylamide-treatment and responses to phenylephrine and potassium in rat aorta(AKADEMIAI KIADO RT, 2012) Atalık, Kısmet Esra Nurullahoğlu; Okudan, Nilsel; Belviranlı, Muaz; Esen, H.; Yener, Y.; Oznurlu, Y.Acrylamide (ACR) is a chemical used in many industries around the world and was found to form naturally in foods cooked at high temperatures. The aim of the present study is to evaluate the influence of ACR treatment on vascular responses to phenylephrine (PHE; 10(-9)-3x10(-4) M) and potassium chloride (KCl; 5-100 mM). We also examined the role of gender in these responses. The animals in both genders were divided into three groups as follows. (1) Control animals, (2) ACR-I; ACR-treated (2 mg/kg-d for 90 days), (3) ACR-II; ACR-treated (5 mg/kg-d for 90 days). Male rat aortas were more sensitive to PHE and KCl than female aortas. ACR-treatment increased the sensitivity to PHE and KCl, in both genders. Compared to the control group, ACR treatment significantly reduced the luminal area of both male and female rat aortas. Furthermore, the responses to PHE and KCl were similar in both 2 mg/kg-d ACR-treated rat aortas with 5 mg/kg-d ACR-treated rat aortas, in both genders. The results of this study suggest that ACR treatment affects vascular contractility and morphology in both gender of rat aorta.Öğe Effect on body weight of botilinum type-A toxin injection into submandibular salivary glands: An experimental study in the rabbit model(2013) Şahin, Mustafa; Erenoğlu, B.; Yılmaz, Hüseyin; Esen, H.; Tolu, A.; Acar, F.; Alptekin, HüsnüBackground: In this study, we investigated the effects of Botulinum type A toxin (Btx-A) injection into salivary glands on body weight at rabbits. Material and Methods: Forty five rabbits were used in this study, and were divided into three groups of 15 rabbits each, as follows: Group I: Control group , Group II: Btx-A was injected with a dosage of 50 IU into left submandibular gland., Group III: Btx-A was injected with a dosage of 50 IU into each of submandibular glands. The rabbits were weighed monthly. At the end of the 6 months, all animals were sacrificed. Small intestine and submandibular salivary glands were excised. The tissue sections was stained with hematoxylin-eosin and immunostained with primary antibodies for epidermal growth factor receptor (EGFR). The length of villi was measured, and the immunostained cells were counted. Results: Body weights measurement showed an increase of 65.2 % over the initial weight in group I, a decrease of 12.1 % in group II and a decrease of 30.6 % in group III (P<0.001). The villi length was 893±63 ? in group I, 712±30 ? in group II and 621±41 ? in group III (P<0.001). The mean immunostained cells count of submandibular glands was 527±90.7 in group I, 267.8±71.1 in group II and 260.2±76.4 in group III (P<0.001). The mean immunostained cells count of intestinal villi was 906.2±45.7 in group I, 786.4±75.6 in group II and 658±84.3 in group III (P<0.001). Conclusion: In this experimental study, Btx-A injection into submandibular salivary glands lead to intestinal villi atrophy and weight loss in rabbit model.Öğe The Effects of Botox Injection to Salivary Glands on Weight Loss(John Wiley & Sons Ltd, 2010) Şahin, Mert; Erenoğlu, B.; Yılmaz, H.; Esen, H.; Tolu, A.; Acar, F.; Alptekin, Hüsnü[Abstract not Available]Öğe Effects of exercise preconditioning on intestinal ischemia-reperfusion injury(COMENIUS UNIV, 2014) Gokbel, H.; Oz, M.; Okudan, N.; Belviranli, M.; Esen, H.Background: To investigate the effects of exercise preconditioning on oxidative injury in the intestinal tissue of rats. Methods: Sixty male Wistar rats were randomly divided into six groups as sham (n = 10), ischemia-reperfusion (n = 10), exercise (n = 10), exercise plus ischemia-reperfusion (n = 10), ischemic preconditioning (n = 10), and ischemic preconditioning plus ischemia-reperfusion groups (n = 10). Tissue levels of malondialdehyde and activities of myeloperoxidase and superoxide dismutase, and serum levels of tumor necrosis factor-alpha and interleukin-6 were measured. Intestinal tissue histopathology was also evaluated by light microscopy. Results: Tumor necrosis factor-alpha concentrations significantly decreased in the exercise group compared to the sham group (p < 0.05). Myeloperoxidase activity significantly increased and superoxide dismutase activity significantly decreased in ischemia-reperfusion group compared to the sham group (p < 0.05). Superoxide dismutase activity in the ischemic preconditioning and ischemic preconditioning plus ischemia-reperfusion groups were significantly higher compared to the ischemia-reperfusion and exercise groups (p < 0.05). Histopathologically, intestinal injury significantly attenuated in the exercise plus ischemia-reperfusion group compared to the ischemia-reperfusion group. Conclusions: The results of the present study indicate that exercise training seems to have a protective role against intestinal ischemia-reperfusion injury (Tab. 3, Fig. 1, Ref. 35). Text in PDF www.elis.sk.Öğe Effects of iloprost and piracetam in spinal cord ischemia-reperfusion injury in the rabbit(NATURE PUBLISHING GROUP, 2011) Kalkan, E.; Keskin, F.; Kaya, B.; Esen, H.; Tosun, M.; Kalkan, S. S.; Erdi, F.Study design: Experimental Study. Objectives: The aim of this study was to investigate the neuroprotective effects of iloprost and piracetam on spinal cord ischemia/reperfusion (I/R) injury in the rabbit. Settings: The Experimental Research Center of Selcuk University, Konya, Turkey. Methods: A total of 24 rabbits were divided into four groups of six rabbits each, as follows: group 1 (n = 6) sham, laparotomy only; group 2 (n = 6) I/R; group 3 (n = 6) I/R + iloprost; and group 4 (n = 6) I/R + piracetam. I/R was established in groups 2, 3 and 4. Subsequently, they were followed up neurologically for 24 h until the rabbits were killed; biochemical and histopathological examinations of samples from the spinal cord were carried out. Results: Neurological examination results were significantly better in the iloprost and piracetam groups compared with the I/R group (P<0.05). Neuroprotection was achieved with iloprost and piracetam by suppressing malondialdehyde (P<0.05), increasing glutathione peroxidase activity (P<0.05) and decreasing the xanthine oxidase level. In histopathological assessment, iloprost and piracetam groups were statistically different from the I/R group in terms of the number of apoptotic neurons in gray matter and white matter, as well as in terms of degenerated neurons and glial cells (P<0.05). No statistical difference was determined between the four groups in the number of degenerated glial cells (P>0.05). Conclusion: This study has shown that iloprost and piracetam have neuroprotective effects in I/R injury both neurologically and histopathologically because of inhibition of lipid peroxidation. Spinal Cord (2011) 49, 81-86; doi: 10.1038/sc.2010.76; published online 29 June 2010Öğe Evaluation of Cervical Involvement in Endometrial Cancer by Transvaginal Sonography, Magnetic Resonance Imaging and Frozen Section(Taylor & Francis Inc, 2010) Çelik, Ç.; Özdemir, S.; Kıreşi, Demet; Emlik, Dilek; Tazegül, A.; Esen, H.This study was undertaken to compare the diagnostic performance of transvaginal sonography (TVS), magnetic resonance imaging (MRI), and frozen section for detection of cervical involvement in endometrial cancer. The study included 64 consecutive patients with endometrial cancer. The subjects were evaluated with TVS and MRI by two radiologists and the frozen sections by a pathologist. The diagnostic accuracies of TVS, MRI and frozen section were compared using the McNemar test. The accuracy rates of TVS, MRI and frozen section were 90.6%, 92.2% and 95.5%, respectively. There were no statistical significant differences in overall diagnostic performance for the preoperative and intraoperative assessment of cervical involvement, although frozen section seemed to be slightly superior to the imaging techniques. TVS and MRI have similar performance in determination of cervical involvement. However, although time consuming and expensive, MRI may be recommended in cases with poor quality TVS. Frozen section may be advocated where preop-tests are equivocal.Öğe An Inflammatory Verrucous Epidermal Nevus Concomitant With Psoriasis: Treatment with Adalimumab(2012) Özdemir, M.; Balevi, A.; Esen, H.A 42-year-old-man presented with generalized inflammatory linear verrucous epidermal nevus with concomitant psoriasis vulgaris. Because of unresponsiveness of the conventional treatment, we considered treatment with adalimumab. Adalimumab was well tolerated and no side effects were observed. Adalimumab has a limited effect in treating ILVEN lesions. However, it was effective in treating the psoriasis and pruritus related to ILVEN. For these reasons adalimumab can be used in treatment of ILVEN concomitant with psoriasis.Öğe Intradural Intramedullary Conus Medullaris Metastasis of Colorectal Adenocarcinoma: A Case Report(Journal Neurological Sciences, 2012) Keskin, F.; Kalkan, E.; Erdi, M. F.; Esen, H.Spinal cord metastasis is rarely seen. Intramedullary spinal metastasis has been defined between the rates of 0,9 -2,1% in the autopsies performed on the cancerous cases. And also intramedullary spinal metastases are defined at a rate of 8,5% in the cases which have metastasis at central nervous system. The male patient, who was at the age of 62, was admitted to our clinic with the complaints of serious back and left leg pain and weakness at the left leg which had begun 15 days before. Low anterior resection + total mesorectal excision + ileostomy were applied to the patient five years ago due to colorectal adenocarcinoma. The carcinoma was reported as adenocarcinoma grade II. Chemotherapy and radiotherapy were applied after postoperative period. Left SLR was positive and 3/5 monoparesis at left leg was determined in the patients neurological examination. Conus medullaris located tumor was determined in the magnetic resonance imaging of the patient. Intradural intramedullary tumor which was infiltrated to the conus medullaris was totally removed with microneurosurgical technique via Th12-L1-2 total laminectomy. Th11-L3 posterior instrumentation and fusion were added because of expansive laminectomy and L1 corpus involvement of the tumor. The histopathological examination was reported as colorectal adenocarcinoma metastasis. In this manuscript we report a colorectal adenocarcinoma metastasis to the conus medullaris for the first time in the literature. Key words: Colorectal adenocarcinoma, conus medullaris, metastasis, surgeryÖğe Protective role of zinc pretreatment in hepatotoxicity induced by halothane(CAMBRIDGE UNIV PRESS, 2008) Unsal, C.; Celik, J. B.; Toy, H.; Esen, H.; Otelcioglu, S.Background and objective: This study was designed to determine the protective effects of zinc on halothane-induced hepatotoxicity. Methods: Forty-five male Sprague-Dawley rats were divided into three groups. The hatothane group received normal drinking water and diet; the zinc-halothane group received 227 mgL(-1) zinc sulphate in the drinking water and diet for 2 weeks; and the control group received normal diet and water. At the end of 2 weeks, rats were housed in an anaesthesia box and 1 MAC (minimum alveolar concentration) halothane was administered at 6 L min(-1) in room air for 2 h. This was repeated 48 h later. After the rats were scrificed, we measured alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, glutamyl transpeptidase, glutathione-S-transferase, serum electrolytes and bilirubin in samples. The degree of liver toxicity was assessed by light microscopic examination. Results: We demonstrated a reduction of alanine aminotransferase, aspartate amino transferase, glutathione-S-transferase levels and a reduction in liver damage in the zinc-halothane group. Conclusion: The study concludes that zinc has the potential to alleviate the toxic effects of halothane in rat liver.Öğe Responses of acrylamide-treated rat bladders(COMENIUS UNIV, 2013) Atalık, Kısmet Esra Nurullahoğlu; Okudan, Nilsel; Belviranlı, Muaz; Esen, H.; Yener, Y.; Celik, IObjective: Acrylamide (ACR) is a chemical used in many industries around the world and more recently was found to be formed naturally in foods cooked at high temperatures. ACR was shown to be a neurotoxicant, reproductive toxicant, and carcinogen in animal species. The aim of the present study is to evaluate the influence of ACR treatment on urinary bladder responses to carbachol (10(-9)-3x10(-4) M) and potassium chloride (KCl; 5-100 mM), each of them causes receptor-dependent and receptor-independent contractions, respectively. We also examined the role of gender in these responses. Material and methods: Rats of both genders were divided into three groups as follows: (1) Control animals (2) ACR-I; ACR-treated (2 mg/kg-d for 90 days) (3) ACR-II; ACR-treated (5 mg/kg-d for 90 days). Results: In rats treated with ACR, the EC50 values of carbachol and KCl, but not the maximal response, to both agents were significantly higher than in control group. Histopathological parameters such as edema, congestion, inflammatory cells, microvascular proliferation, fibrosis, eosinophils, mast cells and epithelial damage were all higher in the ACR-treated group than in the controls. Conclusions: These results demonstrate for the first time that ACR-treatment can induce urinary bladder injury (Tab. 4, Fig. 4, Ref. 30). Full Text in PDF www.elis.sk.Öğe Role of curcumin in mesenteric ischemia - reperfusion injury in rats(COMENIUS UNIV, 2012) Atalık, Kısmet Esra Nurullahoğlu; Okudan, Nilsel; Belviranlı, Muaz; Gökbel, Hakkı; Öz, Mehmet; Esen, H.Background: Curcumin is an antioxidant molecule that has been shown to attenuate ischemia/reperfusion (I/R) injury in several organ systems. In the present study, we aimed to evaluate the possible effects of curcumin on contractile response to agonists and histopathological alterations in rat esophagus subjected to mesenteric I/R. Materials and methods: Adult male Wistar albino rats were randomly allocated to 4 groups, namely group I: sham-operated animals (n=10); group II: animals subdued to I/R injury only (n=10) and laparotomy; 45 minutes of superior mesenteric artery ligation were followed by 2 hours of reperfusion, group III: curcumin/sham (n=10); 20 days before I/R, curcumin (200 mg/kg/) was administered by gastric gavage, and group IV: curcumin-I/R (n=10). Mesenteric ischemia/reperfusion model was generated by clamping the superior mesenteric artery for 45 min followed by reperfusion for 2 h. Oral administration of curcumin by gavage at a dose of 200 mg/kg/day lasted 20 days just before inducing the mesenteric ischemia. At the end of reperfusion period, all animals were sacrificed and esophagus samples were collected to assess the contractile response to agonists and histopathological alterations. Results: Ischemia/reperfusion significantly decreased the contractile responses to carbachol and KCl and this decrease was attenuated by curcumin. Pretreatment with curcumin caused a remarkable decrease in histopathological parameters such as edema, congestion and inflammatory cells. Conclusions: The results of the present study demonstrate for the first time that curcumin can attenuate the esophageal injury associated with I/R (Tab. 4, Fig. 3, Ref. 32). Full Text in PDF www.elis.sk.Öğe The use of ankaferd might lead to wound dehiscence in midline laparotomy incision(2011) Alptekin, Hüsnü; Yılmaz, Hüseyin; Erdem, S.; Esen, H.; Kurban, S.; Şahin, MustafaBackground: Ankaferd Blood Stopper® offered as a hemostatic agent is a standardized herbal extract obtained from five different plants. The effects of ABS on laparotomy incision are unknown. This study was designed to assess potential effects on the healing of midline laparotomy in an experimental animal model. Material and Methods: Sixteen male Wistar albino rats were randomized into two groups and subjected to laparotomy. The study group subjected to laparotomy with local application of ABS to the bleeding points in the subcutaneous tissue, muscle and fascia and the control group subjected to laparotomy only. The rats were killed on postoperative day 7. Three types of assessment were performed: wound breaking strength, histopathology, and biochemical analysis. Results: Compared to the control group, rats in the ABS group displayed a lower wound breaking strength (p<0.05) and tissue hydroxyproline content (p<0.05). The use of ABS leads to a significant increase in malondealdehyde levels (p<0.05). Total histopathological score of groups were similar (p>0.05). Conclusion: Topical application of ABS to the subcutaneous tissue, muscle and fascia significantly impairs the wound healing by means of decreasing mechanical strength and tissue HPL levels.
