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Öğe Circulating leptin, zinc, and copper levels after extracorporeal circulation(MAGHIRA & MAAS PUBLICATIONS, 2005) Gormus, ZI; Gormus, N; Baltaci, AK; Halifeoglu, I; Mogulkoc, ROBJECTIVE: The role of leptin in the acute stress response to extracorporeal circulation has been well documented, however, the relationship between leptin and zinc has not been investigated previously. We aimed to research the circulating leptin, zinc, and copper levels before, during, and after the extracorporeal circulation, and effect of preoperative zinc administration to these. METHODS: Twenty patients who were taken to elective coronary artery bypass grafting operations using extracorporeal circulation were taken to this research and divided into two equal groups (n(1), n(2)). In both groups blood samples were taken just before the operation (T0), at the end of operation (T1), and at the first postoperative day (T2). In the second group (n(2)) oral zinc (50 mg, once a day) was administered to patients for 5 days, preoperatively. The serum leptin, zinc, and copper levels were studied. RESULTS: In group n(1) circulating leptin levels were significantly increased at T2 when compared to T0 and T1 (p < 0.05); zinc levels were decreased at T2 when compared to T0 and T1 (p < 0.05); copper levels were decreased at T2 when compared to T0 (p < 0.05), and decreased at T1 when compared to T0 (p < 0.05). In group n(2) circulating leptin levels were significantly increased at T2 when compared to T0 and T1 (p < 0.05); zinc levels were decreased at T2 when compared to T0 and T1 (p < 0.05); copper levels were increased at T2 when compared to T1 (p < 0.05). CONCLUSIONS: These results indicate that circulating leptin levels increase after the extracorporeal circulation as an acute response, while zinc and copper levels decrease at the same period. Preoperative zinc administration does not prevent the leptin response after extracorporeal circulation.Öğe Effect of boron supplementation on plasma element distribution in ovariectomized rats subjected to acute swimming exercise(COMENIUS UNIV, 2011) Yazici, Z.; Baltaci, A. K.; Mogulkoc, R.; Halifeoglu, I; Kaya, Y.Background: This study aims to examine how boron supplementation affects distribution of elements in the plasma of rats whose ovaries were removed and who were subjected to swimming exercise. Methods: The study included 80 Sprague-Dawley type female rats, which were equally allocated to 8 groups. Group 1: General control, Group 2: Exercise control; Group 3: Ovariectomized control, Group 4: Ovariectomized exercise, Group 5: IP (intraperitoneal) boron-supplemented control, Group 6: IP boron-supplemented exercise, Group 7: Ovariectomized, IP boron-supplemented exercise, group 8: Ovariectomized, IP boron-supplemented. Following the exercise, blood samples were collected from all animals by decapitation, and analyzed in terms of plasma copper, iron, phosphorus, magnesium, calcium, and zinc using an atomic absorption spectrophotometer. Results: Groups 1 and 5 had the lowest copper (p<0.01) and the highest zinc and calcium (p<0.01) levels, in comparison to other groups. Phosphorus levels in groups 3, 5 and 8 were significantly lower than those in other groups (p<0.01). Magnesium levels in groups 3, 5 and 8 were higher, relative to the levels in other groups (p<0.01). Conclusion: Results of the study indicate that acute swimming exercise in ovariectomized rats supplemented with boron leads to significant modifications in the distribution of some trace elements in the plasma. It can be emphasized as a separate result of this study that changes in copper, zinc and calcium levels were independent of boron supplementation (Tab. 2, Ref. 14). Full Text in free PDF www.bmj.sk.Öğe Effects of trace element levels on platelet aggregation(HUMANA PRESS INC, 2004) Kurtoglu, E; Ugur, A; Baltaci, AK; Halifeoglu, IPlatelet aggregation was measured by an optical method in 32 patients with iron-deficiency anemia at the time of diagnosis and after a period of Supplementation with iron. Epinephrine- and adenosine diphosphate-induced platelet aggregation were lower in anemic patients than in the controls (p<0.05). After iron-supplementation therapy, these values showed no significant differences. If induced by collagen or ristocetin, platelet aggregation was the same for patients and controls, but increased after treatment of patients (p<0.05). The plasma zinc values did not show significant differences among the subjects included in this study. These results show that iron is involved in the enzymatic systems that regulate platelet aggregation. The exact nature of this interaction is still to be determined.Öğe Effects of zinc deficiency and supplementation on plasma leptin levels in rats(HUMANA PRESS INC, 2005) Baltaci, AK; Mogulkoc, R; Halifeoglu, IThe effects of zinc deficiency and supplementation on plasma leptin levels were studied in Sprague-Dawley rats. After 6 wk on a zinc-deficient diet containing 0.65 ppm Zn/g, the mean body weight was significantly lower than that of normal or zinc-supplemented rats, which showed no difference among them. The plasma leptin and zinc levels were lowest in zinc-deficient animals and highest in those that received a normal diet and daily intraperitioneal injections of 3 mg Zn/kg. These results indicate that zinc deficiency leads to a significant inhibition in plasma leptin levels, whereas zinc supplementation significantly increases plasma leptin.
