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    Assessment of dermal wound healing and in vitro antioxidant properties of Avena sativa L.
    (ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2011) Akkol, Esra Küpeli; Suntar, I.; Orhan, I. Erdogan; Keles, H.; Kan, A.; Coksari, G.
    Avena sativa L (Poaceae) has been reported to have traditional utilization against skin diseases and inflammation. Therefore, in this study, the n-hexane, ethyl acetate, ethanol, and water extracts of A. sativa were investigated for their wound healing and antioxidant activities. Total phenol and flavonoid contents of the extracts were established spectrophotometrically. For the wound healing activity, linear incision and circular excision models on rats and mice were evaluated with a standard ointment Madecassol. Antioxidant activity was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferrous ion-chelating, and ferric-reducing antioxidant power (FRAP) assays. Significant wound healing activity was observed with the ointment formulation of the ethanol extract at 1% concentration. The histopathological examination results also supported the outcome of both linear incision and circular excision wound models. All of the extracts exerted low antioxidant activity in the applied assays. The present study provides a scientific evidence for the traditional usage of A. sativa in the management of wound healing. (C) 2011 Published by Elsevier Ltd.
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    Elemental Compositions of Soybean Cultivars Cultivated in Turkey
    (GEORG THIEME VERLAG KG, 2011) Kan, A.
    [Abstract not Available]
  • Küçük Resim
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    In Vitro Antimicrobial Activities of Cicer Arietinum L (Chickpea)
    (Pharmacotherapy Group, 2010) Kan, A.; Özçelik, B.; Kartal, M.; Özdemir, Z. A.; Özgen, S.
    Purpose: To evaluate the antibacterial and antifungal activities of the extracts of the seed, fruit skin and aerial parts of ten registered varieties of Cicer arietinum (Chickpea) Method: Susceptibility testing was performed according to the Clinical and Laboratory Standards Institute (CLSI) and used an inhibition endpoint for determination of the minimum inhibition concentration (MIC). The tests were carried out by microdilution method against standard strains of E. coli, P. aeruginosa, K. pneumoniae, S. aureus, B. subtilis, and E. faecalis for their antibacterial activity using ampicillin and oflaxocin as reference standards, and against C. albicans with ketocanazole and flukonazole as reference standards for antifungal activity. Results: Chickpea seed extracts (Cse) showed antibacterial activity against Gram-negative strains (E. coli, P. aeruginosa and K. pneumoniae) in the concentration range of 16-64 µg ml but were less active (concentration of 64 µg ml¹) against Gram-positive strains (S. aureus, B. subtilis and E. faecalis). Conclusion: This is the first report showing that C. arietinum extracts has substantial antifungal activity at a concentration as low as 8 µg ml.