Assessment of dermal wound healing and in vitro antioxidant properties of Avena sativa L.
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Avena sativa L (Poaceae) has been reported to have traditional utilization against skin diseases and inflammation. Therefore, in this study, the n-hexane, ethyl acetate, ethanol, and water extracts of A. sativa were investigated for their wound healing and antioxidant activities. Total phenol and flavonoid contents of the extracts were established spectrophotometrically. For the wound healing activity, linear incision and circular excision models on rats and mice were evaluated with a standard ointment Madecassol. Antioxidant activity was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferrous ion-chelating, and ferric-reducing antioxidant power (FRAP) assays. Significant wound healing activity was observed with the ointment formulation of the ethanol extract at 1% concentration. The histopathological examination results also supported the outcome of both linear incision and circular excision wound models. All of the extracts exerted low antioxidant activity in the applied assays. The present study provides a scientific evidence for the traditional usage of A. sativa in the management of wound healing. (C) 2011 Published by Elsevier Ltd.
Açıklama
Anahtar Kelimeler
Avena sativa, Wound healing, Antioxidant, Total phenol and flavonoid
Kaynak
JOURNAL OF CEREAL SCIENCE
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
53
Sayı
3
