Assessment of dermal wound healing and in vitro antioxidant properties of Avena sativa L.

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dc.contributor.authorAkkol, Esra Küpeli
dc.contributor.authorSuntar, I.
dc.contributor.authorOrhan, I. Erdogan
dc.contributor.authorKeles, H.
dc.contributor.authorKan, A.
dc.contributor.authorCoksari, G.
dc.date.accessioned2020-03-26T18:13:49Z
dc.date.available2020-03-26T18:13:49Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAvena sativa L (Poaceae) has been reported to have traditional utilization against skin diseases and inflammation. Therefore, in this study, the n-hexane, ethyl acetate, ethanol, and water extracts of A. sativa were investigated for their wound healing and antioxidant activities. Total phenol and flavonoid contents of the extracts were established spectrophotometrically. For the wound healing activity, linear incision and circular excision models on rats and mice were evaluated with a standard ointment Madecassol. Antioxidant activity was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferrous ion-chelating, and ferric-reducing antioxidant power (FRAP) assays. Significant wound healing activity was observed with the ointment formulation of the ethanol extract at 1% concentration. The histopathological examination results also supported the outcome of both linear incision and circular excision wound models. All of the extracts exerted low antioxidant activity in the applied assays. The present study provides a scientific evidence for the traditional usage of A. sativa in the management of wound healing. (C) 2011 Published by Elsevier Ltd.en_US
dc.identifier.doi10.1016/j.jcs.2011.01.009en_US
dc.identifier.endpage290en_US
dc.identifier.issn0733-5210en_US
dc.identifier.issn1095-9963en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage285en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jcs.2011.01.009
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26166
dc.identifier.volume53en_US
dc.identifier.wosWOS:000292226600003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofJOURNAL OF CEREAL SCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAvena sativaen_US
dc.subjectWound healingen_US
dc.subjectAntioxidanten_US
dc.subjectTotal phenol and flavonoiden_US
dc.titleAssessment of dermal wound healing and in vitro antioxidant properties of Avena sativa L.en_US
dc.typeArticleen_US

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