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Öğe Alpha Lipoic Acid Treatment Improved Endothelium-dependent Relaxation in Diabetic Rat Aorta(PHARMACEUTICAL SOC JAPAN, 2011) Okudan, Nilsel; Atalık, Kısmet Esra Nurullahoğlu; Gökbel, Hakkı; Canbilen, A.; Kara, I.The aim of this study was to ascertain the effects of alpha-lipoic acid (ALA) treatment on relaxant responses of acetylcholine (ACh) and isoprenaline (ISO) in aortic rings precontracted with serotonin (5-HT, 10(-6) M) obtained from streptozotocin (STZ) -induced diabetic rats. Diabetes was induced in the rats by 50 mg/kg streptozotocin (STZ) via an intraperitoneal injection. Rat body and aorta weights were measured. The isometric tension to ACh (10(-9)-3 X 10(-6) M) and ISO (10(-9)-10(-4) M) of 5-HT-precontracted diabetic and non-diabetic rat (control), diabetic-ALA-treated, and ALA-treated aortas, in organ baths were recorded. Six weeks after STZ treatment blood glucose was elevated compared to control rats. In aortic rings from diabetic rats ACh and ISO-induced relaxations were impaired whereas endotheliumin-dependent relaxation to sodium nitroprusside (SNP) was unaffected. ALA (100 mg/kg/day) treatment for 5 weeks enhanced ACh and ISO-induced relaxation in diabetic aortas. This recovering effect was via NO because prevented by incubating the vessels with N-G-nitro-L-arginine methyl ester (L-NAME, a NOS inhibitor). It may be assumed that ALA treatment in vivo, can protect against impaired vascular responsiveness in STZ-induced diabetic rats.Öğe Effect of Dexmedetomidine on Pain Caused by Injection of Propofol(2012) Şarkılar, G.; Kara, I.; Duman, A.; Aygın, F.; Ökeşli, S.Objective: This study was designed to assess the local and systemic effects of two different pre-anesthetic infusion dose of dexmedetomidine in preventing propofol injection pain. Material and Method: Two hundred fifty adults were assigned into five groups. Before injection of propofol, group 1 (placebo n=50) received an infusion of saline solution, group 2 (n=50) received 0.5 ?g kg -1 of dexmedetomidine and group 3 (n=50) received 1 ?g kg -1 of dexmedetomidine from the same vein. Group 4 (n=50) received 0.5 ?g kg -1 of dexmedetomidine and group 5 (n=50) received 1 ?g kg -1 dexmedetomidine followed by an injection of propofol from a vein located in the opposite hand. Pain assessment was made immediately after propofol injection. Results: Two hundred twenty five patients completed the study. The number of patients who suffered from any degree of pain was significantly high when compared to dexmedetomidine group (p=0.05). When compared with placebo and opposite hand, administering dexmedetomidine from the same vein was more efficient to prevent propofol pain (p=0.003). 1 ?g kg -1 of dexmedetomidine was similar to 0.5 ?g kg -1 of dexmedetomidine in preventing propofol pain.Conclusion: Dexmedetomidine infusions in pre-anesthetic sedative doses of 0.5 ?g kg -1 and 1 ?g kg -1 decrease the incidence of propofol injection pain compared to placebo.Öğe The Effects of Intrathecal Morphine on Patient-controlled Analgesia, Morphine Consumption, Postoperative Pain and Satisfaction Scores in Patients Undergoing Gynaecological Oncological Surgery(SAGE PUBLICATIONS LTD, 2012) Kara, I.; Apiligullari, S.; Oc, B.; Celik, J. B.; Duman, A.; Celik, C.; Dogan, N. U.OBJECTIVE: Gynaecological oncological surgery (GOS) includes a wide variety of surgical procedures and postoperative pain is a major concern. This study compared the impact of intrathecal morphine (ITM) plus patient-controlled analgesia (PCA) with PCA alone on morphine consumption, pain relief and patient satisfaction after GOS. METHODS: Sixty women undergoing GOS under general anaesthesia were randomized to receive either 0.3 mg ITM or placebo. On arrival at the postanaesthesia care unit each patient received a morphine PCA pump. The three primary outcome measures were pain, patient satisfaction scores evaluated using a 100-mm visual analogue scale and cumulative PCA morphine consumption. RESULTS: No significant differences were observed in the demographic data. Cumulative PCA morphine consumption was significantly lower in the ITM group compared with the control group. Fatigue scores were lower in the ITM group compared with the control group but did not reach statistical significance. Pain, sedation and patient satisfaction scores, and the rate of side-effects were similar for the two groups. CONCLUSIONS: Administering ITM in GOS could improve postoperative analgesia and reduce morphine consumption without serious side-effects.Öğe The Relationship between Bioimpedance Analysis, Haemodynamic Parameters of Haemodialysis, Biochemical Parameters and Dry Weight(FIELD HOUSE PUBLISHING LLP, 2011) Celik, G.; Kara, I.; Yilmaz, M.; Apiliogullari, S.Adequate fluid management plays an important role in the treatment of haemodialysis patients and the assessment of dry weight is important for efficient therapy. Fluid volume parameters were assessed in adults undergoing haemodialysis for end-stage renal disease, using whole-body multifrequency bioimpedance analysis (BIA), and their relationship to haemodynamic and biochemical parameters of haemodialysis was evaluated. Ultrafiltration volume was correlated with age, sodium, haemoglobin, extracellular water (ECW)/total body water (TBW) ratio and ECW/intracellular water (ICW) ratio. The ECW/TBW ratio was correlated with age, body mass index, dry weight, predialysis systolic and diastolic blood pressure, and ECW/total body weight ratio. The ECW/ICW ratio correlated with age, dry weight, TBW, albumin, adequacy of dialysis and urea removal ratio. The study demonstrated a close relationship between bioimpedance-derived fluid volume parameters and the haemodynamic and biochemical parameters of haemodialysis. It is concluded that multifrequency whole-body BIA may have clinical value in the estimation of dry weight and other haemodynamic parameters of haemodialysis and so may protect patients from the risks associated with under- or over-hydration.
