Effect of Dexmedetomidine on Pain Caused by Injection of Propofol
Küçük Resim Yok
Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: This study was designed to assess the local and systemic effects of two different pre-anesthetic infusion dose of dexmedetomidine in preventing propofol injection pain. Material and Method: Two hundred fifty adults were assigned into five groups. Before injection of propofol, group 1 (placebo n=50) received an infusion of saline solution, group 2 (n=50) received 0.5 ?g kg -1 of dexmedetomidine and group 3 (n=50) received 1 ?g kg -1 of dexmedetomidine from the same vein. Group 4 (n=50) received 0.5 ?g kg -1 of dexmedetomidine and group 5 (n=50) received 1 ?g kg -1 dexmedetomidine followed by an injection of propofol from a vein located in the opposite hand. Pain assessment was made immediately after propofol injection. Results: Two hundred twenty five patients completed the study. The number of patients who suffered from any degree of pain was significantly high when compared to dexmedetomidine group (p=0.05). When compared with placebo and opposite hand, administering dexmedetomidine from the same vein was more efficient to prevent propofol pain (p=0.003). 1 ?g kg -1 of dexmedetomidine was similar to 0.5 ?g kg -1 of dexmedetomidine in preventing propofol pain.Conclusion: Dexmedetomidine infusions in pre-anesthetic sedative doses of 0.5 ?g kg -1 and 1 ?g kg -1 decrease the incidence of propofol injection pain compared to placebo.
Açıklama
Anahtar Kelimeler
Dexmedetomidine, Pain, Propofol
Kaynak
Nobel Medicus
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
8
Sayı
1
Künye
Şarkılar, G., Kara, I., Duman, A., Aygın, F., Ökeşli, S., (2012). Effect of Dexmedetomidine on Pain Caused by Injection of Propofol. Nobel Medicus, 8(1), 83-88.
