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  • Küçük Resim
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    The Incidence of Cystic Fibrosis in the Central Region of Anatolia in Turkey Between 2015 and 2016
    (2019) Hangül, Melih; Pekcan, Sevgi; Köse, Mehmet; Acıcan, Deniz; Şahlar, Tuba Esra; Erdoğan, Murat; Kendirci, Mustafa; Güney, Deniz; Öznavruz, Hasan; Demir, Osman; Ercan, Ömür; Göçlü, Fatma
    Background: Cystic fibrosis is the most common metabolic chronic disease among European Caucasian children. Cystic fibrosis incidence in Northern Europeans countries is approximately 1 in 3000 births while the worldwide prevalence varies considerably.Aims: To determine the incidence of cystic fibrosis in the central region of Anatolia in Turkey using the newborn screening program data.Study Design: Cross-sectional study.Methods: We used the records of the newborn screening program which is implemented by the Konya and Kayseri Provincial Health Directories. Between January 2015 and December 2016, there were a total of 119006 live births in Konya and Kayseri. The newborn screening test was applied to all these babies.Results: During this period, there were 22 live born babies diagnosed with cystic fibrosis in Konya with an incidence of 2.9 per 10000 live births and 13 live born babies diagnosed with cystic fibrosis in Kayseri with an incidence of 2.8 per 10000 live births. In genetic of 30 patients, fifteen patients were homozygous, and 15 patients were a compound heterozygote. Twenty-one different gene variants were detected and the most common mutation was F508del (17/30)Conclusion: We found the incidence of cystic fibrosis in central Anatolia similar to northern European countries.
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    Insulin-like Growth Factor-i and Insulin-like Growth Factor Binding Protein-3 Levels of Children Living in an Iodine- and Selenium-deficient Endemic Goiter Area
    (HUMANA PRESS INC, 2002) Aydın, Kürşad; Bideci, Aysun; Kendirci, Mustafa; Cınaz, Peyami; Kurtoğlu, Selim
    Serum insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) levels were investigated in 31 children living in an endemic goiter area and 33 healthy subjects living in an nonendemic area. Serum lGF-I and IGFBP-3 levels of iodine- and selenium deficient children were found to be lower than those of control subjects (p<0.001). There was a positive correlation between the IGF-I with chronological age and body mass index. There was also positive correlation between the lGF-I and IGFBP-3. No significant difference was found between the goitrous and nongoitrous children. These results suggest that IGF-I and IGFBP-3 levels are affected by thyroid dysfunction as a result of iodine and selenium deficiency. However, IGF-I and IGFBP-3 levels are not associated with goiter.
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    Iodine and Selenium Deficiency in School-Children in an Endemic Goiter Area in Turkey
    (FREUND PUBLISHING HOUSE LTD, 2002) Aydın, Kürşad; Kendirci, Mustafa; Kurtoğlu, Selim; Karaküçük, E. İnci; Kırış, Adem
    Endemic goiter is one of the most important health problems in Turkey. However, there are not enough studies associated with iodine and selenium status. This study was carried out to establish the effects of iodine and selenium levels on thyroid gland size and thyroid functions in 73 healthy school-children, 7-12 years old (mean 9.56 +/- 1.77 years), 38 girls (52%) and 35 boys (48%), living in an endemic goiter area. Goiter was found in 32 of the children (43.8%) by palpation, and 56 of the children (76.7%) by ultrasonography. Mean serum T-3 and TSH levels were in the upper limit of normal, and mean serum T-4 levels were within the normal limits, but mean serum thyroglobulin levels were higher than the normal limits. Mean serum selenium level was 30.84 +/- 23.04 mug/l, and mean urinary iodine level was 3.91 +/- 3.77 mug/dl, appropriate for moderate iodine and selenium deficiency. Thyroid volumes of the children were negatively correlated with serum selenium levels, but there was no correlation with urinary iodine levels and thyroid hormones. In conclusion, school-children in this area had significant goiter problems, probably due to the iodine and selenium deficiencies.