Yazar "Khan, Haroon" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • Küçük Resim
    Öğe
    Antibacterial, cytotoxicity, and phytotoxicity profiles of three medicinal plants collected from Pakistan
    (Marmara University, 2017) Rauf, Abdur; Uysal, Sengul; Ben Hadda, Taibi; Siddiqui, Bina S.; Khan, Haroon; Khan, Muhammad Atif; Ijaz, Muhammad; Mubarak, Mohammad S.; Bawazeer,Saud; Izneid,Tareq Abu; Khan, Ajmal; Farooq,Umar
    The purpose of present research was to examine the antibacterial, cytotoxic, and phytotoxic profiles of three important Pakistani medicinal plants viz., Teucrium stocksianum, Chenopodium botrys, and Micromeria biflora. The antibacterial, cytotoxicity, and phytotoxicity activities of samples extracted from these plants were evaluated by a modified agar well-diffusion method, brine shrimps cytotoxic assay, and Lemna acquinoctialisbased phytotoxic assay, respectively. Results revealed marked susceptibility of both the crude extracts and the aqueous fractions of these plants against K. pneumonia and B. subtilis. Methanolic extracts and aqueous fractions exhibited significant cytotoxicity in a concentration-dependent manner. Similarly, an outstanding phytotoxic effect was observed for the extracts/ fractions. Accordingly, the extracts and fractions of the aforementioned plants possess potential antibacterial, cytotoxic, and phytotoxic effects which could be useful in the search and development of new pharmaceutical agents. © 2017, Marmara University. All rights reserved.
  • Küçük Resim
    Öğe
    Antibacterial, cytotoxicity, and phytotoxicity profiles of three medicinal plants collected from Pakistan
    (MARMARA UNIV, FAC PHARMACY, 2017) Rauf, Abdur; Uysal, Sengul; Ben Hadda, Taibi; Siddiqui, Bina S.; Khan, Haroon; Khan, Muhammad Atif; Ijaz, Muhammad; Mubarak, Mohammad S.; Bawazeer,Saud; Izneid,Tareq Abu; Khan, Ajmal; Farooq,Umar
    The purpose of present research was to examine the antibacterial, cytotoxic, and phytotoxic profiles of three important Pakistani medicinal plants viz., Teucrium stocksianum, Chenopodium botrys, and Micromeria biflora. The antibacterial, cytotoxicity, and phytotoxicity activities of samples extracted from these plants were evaluated by a modified agar well-diffusion method, brine shrimps cytotoxic assay, and Lemna acquinoctialis-based phytotoxic assay, respectively. Results revealed marked susceptibility of both the crude extracts and the aqueous fractions of these plants against K. pneumonia and B. subtilis. Methanolic extracts and aqueous fractions exhibited significant cytotoxicity in a concentration-dependent manner. Similarly, an outstanding phytotoxic effect was observed for the extracts/fractions. Accordingly, the extracts and fractions of the aforementioned plants possess potential antibacterial, cytotoxic, and phytotoxic effects which could be useful in the search and development of new pharmaceutical agents.
  • Küçük Resim Yok
    Öğe
    In vivo and in silico sedative-hypnotic like activity of 7-methyljuglone isolated from Diospyros lotus L.
    (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017) Rauf, Abdur; Uysal, Sengul; Ben Hadda, Taibi; Uddin, Ghias; Nawaz, Muhammad Asif; Khan, Haroon; Siddiqui, Bina S.
    Diospyros lotus L. possesses different therapeutic activities such as antioxidant, anti-proliferative, antimicrobial and sedative. However, no studies on the sedative-hypnotic activity of 7-methyljuglone are reported. In the present study, we have evaluated in vivo the anxiolytic-hypnotic like effects of 7-methyljuglone in mice with open field and phenobarbitone-induced sleeping time tests. We have also assessed in silico the involvement of GABA(A), GABA(B) and 5HT1 neurotransmission in its mechanism of action. The intraperitoneal administration of 7-methyljuglone (2.5-10 mg/kg) reduce significantly the number of crossed lines in mice open field test and concomitantly it shown a significant activity in term of onset of sleeping time and also in its duration. Moreover, 7-methyljuglone demonstrated in silico an interesting interaction with GABAA but not GABAB and 5HT1binding sites. All of these results, taken together, 7-methyljuglone may be an innovative candidate for designing new pharmaceutical and therapeutic applications. (C) 2017 Elsevier Masson SAS. All rights reserved.
  • Küçük Resim
    Öğe
    The role of flavonoids in autoimmune diseases: Therapeutic updates
    (PERGAMON-ELSEVIER SCIENCE LTD, 2019) Rengasamy, Kannan R. R.; Khan, Haroon; Gowrishankar, Shanmugaraj; Lagoa, Ricardo J. L.; Mahomoodally, Fawzi M.; Khan, Ziyad; Suroowan, Shanoo; Tewari, Devesh; Zengin, Gökhan; Hassan, Sherif T.S.; Pandian, Shunmugiah Karutha
    Flavonoids are natural polyphenolic compounds which are included in a panoply of drugs and used to treat and/or manage human ailments such as metabolic, cardiovascular, neurological disorders and cancer. Thus, the purpose of this review is to emphasize the importance of flavonoids for the treatment of autoimmune diseases and put into the limelight of the scientific community several health-promoting effects of flavonoids which could be beneficial for the development of novel drugs from natural products. Despite available reviews on flavonoids targeting various disease conditions, a comprehensive review of flavonoids for autoimmune diseases is still lacking. To the best of our knowledge, this is the first attempt to review the potential of flavonoids for autoimmune diseases. The structure-activity relationship of flavonoids in this review revealed that the rearrangement and introduction of other functional groups into the basic skeleton of flavonoids might lead to the development of new drugs which will be helpful in relieving the painful symptoms of various autoimmune diseases. (C) 2018 Elsevier Inc. All rights reserved.