The role of flavonoids in autoimmune diseases: Therapeutic updates
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
PERGAMON-ELSEVIER SCIENCE LTD
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Flavonoids are natural polyphenolic compounds which are included in a panoply of drugs and used to treat and/or manage human ailments such as metabolic, cardiovascular, neurological disorders and cancer. Thus, the purpose of this review is to emphasize the importance of flavonoids for the treatment of autoimmune diseases and put into the limelight of the scientific community several health-promoting effects of flavonoids which could be beneficial for the development of novel drugs from natural products. Despite available reviews on flavonoids targeting various disease conditions, a comprehensive review of flavonoids for autoimmune diseases is still lacking. To the best of our knowledge, this is the first attempt to review the potential of flavonoids for autoimmune diseases. The structure-activity relationship of flavonoids in this review revealed that the rearrangement and introduction of other functional groups into the basic skeleton of flavonoids might lead to the development of new drugs which will be helpful in relieving the painful symptoms of various autoimmune diseases. (C) 2018 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
Inflammation, Immune system, Medicinal plants, Multiple sclerosis, Polyphenols, Rheumatoid arthritis
Kaynak
PHARMACOLOGY & THERAPEUTICS
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
194
Sayı
Künye
Rengasamy, K.R.R., Khan, H., Gowrishankar, S., Lagoa, R.J.L., Mahomoodally, F.M., Khan, Z., Suroowan, S., Tewari, D., Zengin, G., Hassan, S.T.S., Pandian, S.K. (2019). The Role of Flavonoids in Autoimmune Diseases: Therapeutic Updates. Pharmacology & Therapeutıcs, 194, 107-131.
