The role of flavonoids in autoimmune diseases: Therapeutic updates

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dc.contributor.authorRengasamy, Kannan R. R.
dc.contributor.authorKhan, Haroon
dc.contributor.authorGowrishankar, Shanmugaraj
dc.contributor.authorLagoa, Ricardo J. L.
dc.contributor.authorMahomoodally, Fawzi M.
dc.contributor.authorKhan, Ziyad
dc.contributor.authorSuroowan, Shanoo
dc.contributor.authorTewari, Devesh
dc.contributor.authorZengin, Gökhan
dc.contributor.authorHassan, Sherif T.S.
dc.contributor.authorPandian, Shunmugiah Karutha
dc.date.accessioned2020-03-26T20:19:34Z
dc.date.available2020-03-26T20:19:34Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractFlavonoids are natural polyphenolic compounds which are included in a panoply of drugs and used to treat and/or manage human ailments such as metabolic, cardiovascular, neurological disorders and cancer. Thus, the purpose of this review is to emphasize the importance of flavonoids for the treatment of autoimmune diseases and put into the limelight of the scientific community several health-promoting effects of flavonoids which could be beneficial for the development of novel drugs from natural products. Despite available reviews on flavonoids targeting various disease conditions, a comprehensive review of flavonoids for autoimmune diseases is still lacking. To the best of our knowledge, this is the first attempt to review the potential of flavonoids for autoimmune diseases. The structure-activity relationship of flavonoids in this review revealed that the rearrangement and introduction of other functional groups into the basic skeleton of flavonoids might lead to the development of new drugs which will be helpful in relieving the painful symptoms of various autoimmune diseases. (C) 2018 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipDST-SERB, New Delhi [PDF/2017/001166/LS]; DBT, GOIDepartment of Biotechnology (DBT) India [BT/BI/25/012/2012]en_US
dc.description.sponsorshipWe would like to thank Dr. Bernd L Fiebich, University Hospital Freiburg, Department of Psychiatry and Psychotherapy, Laboratory of Translational Psychiatry for critical evaluation of manuscript. The author KRRR thank the DST-SERB, New Delhi for financial support in the form of postdoctoral fellowship (File. No. PDF/2017/001166/LS). The authors KRRR, SG and SKP are grateful to the computational and bioinformatics facility provided by the Alagappa University Bioinformatics Infrastructure Facility (funded by DBT, GOI; File No. BT/BI/25/012/2012, BIF).en_US
dc.identifier.citationRengasamy, K.R.R., Khan, H., Gowrishankar, S., Lagoa, R.J.L., Mahomoodally, F.M., Khan, Z., Suroowan, S., Tewari, D., Zengin, G., Hassan, S.T.S., Pandian, S.K. (2019). The Role of Flavonoids in Autoimmune Diseases: Therapeutic Updates. Pharmacology & Therapeutıcs, 194, 107-131.
dc.identifier.doi10.1016/j.pharmthera.2018.09.009en_US
dc.identifier.endpage131en_US
dc.identifier.issn0163-7258en_US
dc.identifier.pmid30268770en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage107en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.pharmthera.2018.09.009
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38321
dc.identifier.volume194en_US
dc.identifier.wosWOS:000457951500007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofPHARMACOLOGY & THERAPEUTICSen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectInflammationen_US
dc.subjectImmune systemen_US
dc.subjectMedicinal plantsen_US
dc.subjectMultiple sclerosisen_US
dc.subjectPolyphenolsen_US
dc.subjectRheumatoid arthritisen_US
dc.titleThe role of flavonoids in autoimmune diseases: Therapeutic updatesen_US
dc.typeReviewen_US

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