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Öğe Büyük Jüvenil Nazofaringeal Angiofibromaların Tedavisi(1995) Uyar, Yavuz; Erongun, Uğur; Karaköse, Serdar; Cenik, Ziya; Özer, Bedri; Kocaoğullar, Yalçın; Sağlam, Kaan; Güney, ÖnderJuvenil Nazofaringeal Angiofıbromalar, adölesan dönemi erkek çocuklarında sık görülen benign bir tümördür. Ancak kafa kaidesinde çeşitliforaminalar vefıssürler yoluyla yayıldıklarından tedavileri bir problem teşkil eder. Bu özellikteki 4 olgumuzun semptomları, tümörün yaygınlığı, uyguladığımız yöntemler ve kompUkasyonlan sunulmuş olup, literatür gözden geçirilerek sonuçlar değerlendirilmiştir.Öğe Echinococcus Infestation of the Splenius Capitis(CARFAX PUBLISHING, 2001) Güney, Önder; Acar, Osman; Kocaoğullar, Yalçın[Abstract not Available]Öğe Infratemporal Approach For Jugular Foramen Meningioma(1993) Erongun, Uğur; Uyar, Yavuz; Çakır, Bilge; Uygun, Ali; Kocaoğullar, YalçınThe properties of tumours of the jugular foramen are presented and the details of the infratemporal A approach. A new technique for neurosurgeons. are discussed.Öğe Intracerebral Schwannoma: Case Report and Review(Springer, 1996) Erongun, Uğur; Özkal, Ertuğ; Acar, Osman; Uygun, Ali; Kocaoğullar, Yalçın; Güngor, SalimA case of intraparenchymal schwannoma of the brain in a 4-year-old girl is presented. Most of the small number of intracranial schwannomas unassociated with cranial nerves, reported have occurred in children or young adults. There is no male or female predominance. Most of the parenchymatous schwannomas are located supratentorially. The presence of a cyst together with the tumor appears to be characteristic of intraparenchymal schwannoma of the brain.Öğe Intramedullary Abscess of the Spinal Cord(2002) Acar, Osman; Güney, Önder; Kocaoğullar, YalçınWe report a rare case of intramedullary spinal cord abscess. The patient was operated on by surgical drainage and appropriate antibiotic therapy. Improvement was seen postoperatively. Significant changes in the presentation, management, and outcome in these more recent cases are emphasized.Öğe Lateral Lomber Kanal Stenozuna Bağlı Ağrının Tedavisinde Karbamazepin'in Etkinliği(1997) Üstün, M. Erkan; Özerbil, Önder M.; Güney, Önder; Kocaoğullar, YalçınBu çalışmada, birçok nöropati ve nevralji'de analjezik amaçlı kullanılan karbamazepin'in, lateral lomber kanal stenozlu hastalarda ağrı üzerine etkinliğinin olup, olmadığı araştırıldı. Çalışmaya yaşları 32 ile 74 arası ve 7'si kadın toplam 14 lateral kanal stenozlu hasta alındı. Bu hastaların en az 6 ay süreli bel ve/veya bacak ağrısı ana yakınması vardı ve steroid olmayan antienflamatuar ve basit analjezik ilaçlarla ağrıları geçmiyordu. Bu hastalara toplam 6 hafta süreyle karbamazepin verildi. 400 mg/ gün dozunda başlanan tedaviye iki hafta sonra cevap alınamayanlarda 800 mg/gün ile devam edildi. Hastaların tedavi öncesi ve sonrası ağrı semptomları, bacak ağrısı şiddeti ve fonksiyonel bozukluk skoru ile değerlendirildi. Hastaların ağrıları tedavi sonrası anlamlı derecede azaldı (p0.01,X2:10) Sonuç olarak lateral kanal stenozunda ağrıyı gidermek amacıyla karbamazepin'i yeni bir alternatif olarak önermekteyiz.Öğe Lateral Posterior Fossa Venous Sinus Relationships to Surface Landmarks(Elsevier Science Inc, 2003) Avcı, Emel; Kocaoğullar, Yalçın; Fossett, Damirez; Caputy, AnthonyBACKGROUND Knowing the location of the venous sinuses in the combined lateral posterior fossa and lateral cranial base approach is important to prevent their inadvertent injury. The identification of surface landmarks related to these structures is useful in planning such surgical approaches. METHODS Twelve injected adult cadaver specimens and 10 dried skulls were used to study the relationship of the venous sinuses to various surface anatomic structures. RESULTS The asterion was not clearly seen in 60% of the studied cadaver sides. The asterion was always clearly seen in the dry skull preparations. The upper margin of the superior nuchal line was found to range from 1.5 mm to 14 mm inferior to the lower margin of the lateral transverse sinus. In 85% of our specimens, the mastoid groove was found to completely overlie the sigmoid sinus. CONCLUSIONS The asterion was found to be variable in its anatomic relations to other identifiable structures. This variability in relation to other posterior fossa bony landmarks limits its overall usefulness as a consistently stable marker for intracranial structures. The first and most superolateral burr hole for lateral posterior fossa procedures can be safely placed 1 cm below the superior nuchal line and 1 cm medial to the top of the mastoid groove. A burr hole in this location will avoid the transverse and sigmoid sinuses, as well as the transverse-sigmoid junction, yet will be high enough and lateral enough to provide easy exposure of these venous sinuses for all lateral posterior fossa procedures. (C) 2003 Elsevier Inc. All rights reserved.Öğe N-Acetylcysteine Prevents Vasospasm After Subarachnoid Hemorrhage(ELSEVIER SCIENCE INC, 2010) Güney, Önder; Erdi, Fatih; Esen, Hasan; Kıyıcı, Aysel; Kocaoğullar, YalçınBackground: This study investigated the ability of NAC to prevent cerebral vasospasm in a rabbit model of SAH. Methods: Twenty-one, male New Zealand white rabbits were randomly divided into 3 groups of 7 rabbits each: group 1 (control), group 2 (SAH only), group 3 (SAH + NAC treatment). NAC (150 mg/kg, single dose, IF) was administered just before SAH and continued until 72 hours after SAH in group 3. Animals were killed 72 hours after SAH. Tissue MDA levels, SOD, and GSH-Px activities were measured, and basilar artery cross-sectional areas, arterial wall thickness, and endothelial apoptosis in a cross section of basillary artery were determined in all groups. Results: Intraperitoneal administration of NAC was found to be. markedly effective against developing a cerebral vasospasm following a SAH in rabbits. It could significantly reduce elevated lipid peroxidation and increase the level of tissue GSH-Px and SOD enzymatic activities. Also, NAC treatment was found to be effective in increasing the luminal area and reducing wall thickness of the basilar artery. The morphology of arteries in the NAC treatment group was well protected. NAC markedly reduced apoptotic index and protects the endothelial integrity. Conclusions: This study demonstrates, for the first time, that NAC treatment attenuates cerebral vasospasm in a rabbit SAH model. NAC treatment has significant neuroprotective effect and markedly prevents cerebral vasospasm after SAH. In conclusion, the NAC treatment might be beneficial in preventing cerebral vasospasm after SAH, thus showing potential for clinical implications.Öğe Pineal Bölgeye Supraserebellar, Oksipital-Transtentoriyal ve Transsinüs Yaklaşımlarının Anatomik Karşılaştırılması(2001) Kocaoğullar, Yalçın; Avcı, Emel; Fossett, DamirezPineal bölge lezyonlarına cerrahi yaklaşımın seçimi halen araştırmaya açık bir konudur. Bu bölgede yer alan kompleks venöz yapılardan dolayı ve anatomik olarak bu bölgenin beyinde derin bir alanda yer alması nedeni ile uygulanacak cerrahi girişimler de zorluk göstermektedir. En az beyin retraksiyonu ile geniş çalışma alanı sağlamak pineal bölge lezyonları için temel hedeftir. Bu çalışmada supraserebellar, oksipital transtentoriyal ve transsinüs yaklaşımlar anatomik olarak karşılaştırılmıştır. Çalışmada renkli silikon ile doldurulmuş onbeş kadavra spesmeni kullanılmış olup literatür ışığı altında .bu yaklaşımlar tartışılmıştır.Öğe Pituitary Tuberculoma(Turkish Neurosurgical Society, 2000) Acar, Osman; Güney, Önder; Kocaoğullar, YalçınWe report a rare case of pituitary tuberculoma. Surgery was performed via the pterional approach, and the lesion was totally excised. Based on the histopathological diagnosis, the patient underwent 9 months of triple-drug antituberculosis treatment with isoniazid, ethambutol and rifampin.Öğe The possibility of deep peroneal nerve neurotisation by the superficial peroneal nerve: an anatomical approach(CAMBRIDGE UNIV PRESS, 1999) Büyükmumcu, Mustafa; Üstün, Mehmet Erkan; Şeker, M.; Kocaoğullar, Yalçın; Sağmanlıgil, AyhanNeurotisation involves transfer of nerves for the restoration of function following injury. A number of nerves have been used in different part of the peripheral nervous system. This study was undertaken to develop a practical and relatively safe surgical approach to the treatment of L4 root lesion's. We examined the effectiveness and safety of neurotisation of the deep peroneal nerve and its branches by the superficial peroneal nerve. Twelve legs of dissected cadavers provided for teaching purposes in the anatomy laboratory were used to display the common peroneal nerve and its branches. Each branch was measured using calipers and analysed to investigate the possibility of neurotisation of the deep peroneal nerve by the superficial peroneal nerve and its branches. It was found that of the measured branches, transposition was possible between those to peroneus longus and tibialis anterior on the basis of their diameter and length. In recent decades, advances in microsurgical reconstruction and understanding of the microanatomy have played major roles in improving the results of surgical treatment of nerve injuries. There is a need for further experimental studies on the feasibility of this surgical approach.Öğe Posterior fossa intraaksiel tümörleri(Selçuk Üniversitesi Tıp Fakültesi, 1995) Kocaoğullar, Yalçın; Erongun, UğurÖğe Preventive Effects of Intraperitoneal Selenium on Cerebral Vasospasm In Experimental Subarachnoid Hemorrhage(Lippincott Williams & Wilkins, 2010) Kocaoğullar, Yalçın; İlik, Kemal; Esen, Hasan; Koç, Osman; Güney, ÖnderVasospasm is an important cause of morbidity and mortality with subarachnoid hemorrhage (SAH). The effect of intraperitoneal administration of selenium, which is an antioxidant on cerebral vasospasm was investigated in an experimental model. By means of intracisternal blood injection model, SAH was induced in 24 rabbits, which were randomly divided into 3 groups (group I = control group, group 2 = SAH alone group, and group 3 = SAH plus selenium group). Basilar artery angiography was performed on day 0 and day 3 as described. Intraperitoneal selenium (0.05 mg/kg) treatment was started after the induction of SAH and administered once a day. Three days later, the animals were killed and the basilar artery was examined histologically for the luminal diameter and thickness of the arterial muscular wall. The mean values for the measurements of angiographic luminal diameter, pathologic luminal area.. Muscular wall thickness derived from the blind observer were analyzed statistically. There was no statistically significant difference in basal angiographic luminal diameter evaluation between groups 1-2-3 (P > 0.005). But in third day angiography; comparison of Group 2 and group 1-3 showed statistically significant differences (P < 0.001). In pathologic investigation; there was statistically significant difference in luminal area and muscular wall thickness of the basilar artery between groups 1, 2, and 3 (P < 0.005). Intraperitoneal selenium treatment was found effective by increasing the angiographic diameter, pathologic luminal area and reducine muscular wall thickness measurements. This is the first study to show that intraperitoneal administration of selenium is effective in preventing vasospasm after SAH in rabbits.Öğe Somatosensory Spinal Cord Evoked Potentials in the Evaluation of the Effect of Dexamethasone in Experimental Spinal Cord Injury(SPRINGER, 1998) Güney, Önder; Acar, Osman; Demir, Orhan; Üstün, M. Erkan; Kocaoğullar, YalçınWe studied the effects of high-dose dexamethasone on amplitude and latency values of spinal cord evoked potentials. Thirty-three rabbits were divided into three equal groups. The first group served as the control group, the others received high-dose (2.5 mg/kg) dexamenthasone, the second group I hour prior to and the third group immediately after the induction of a spinal cord trauma in segment T12. The spinal cord evoked potentials were recorded epidurally from T12 segment 5 min before and 5, 30, 60, 90, 120 and 150 min after trauma. Pretreatment with dexamethasone (group II) prevented the latency delay, and later treatment with dexemethasone (group III) prevented the latency delay partially. Our results suggest that when dexamethasone is given prophylactially it prevents latency alteration, while treatment with dexamethasone after lesioning prevents latency alteration partially. From our results we conclude that pretreatment with dexamethasone may involve different mechanisms than were activated in the posttreatment group.Öğe Submandibular and Intracranial Hydatid Cyst in an Adolescent(Lippincott Williams & Wilkins, 2002) Güney, Önder; Öztürk, Kayhan; Kocaoğullar, Yalçın; Eser, Olcay; Acar, OsmanObjectives: An unusual case of hydatid disease is reported. Review of the pertinent literature did not reveal any hydatid disease located simultaneously in both the intracranial and submandibular glands. This is the first case with hydatid disease occurring in both locations at the same time. Study Design: The case of an 18-year-old is presented; the symptoms, findings, methods of diagnosis, and our approach for treatment are discussed; and the literature is reviewed. Results. The intracranial lesion was completely excised by left-sided frontoparietal craniotomy, and the mass in the right side of the submandibular gland was removed through a submandibular approach at the same session. The intact cyst was completely excised. Histological examination of both lesions confirmed the diagnosis of hydatid cyst by Echinococcus granulosus. Postoperative recovery was uneventful, and the patient was discharged on the seventh day. Conclusions. Hydatid cyst should be suspected during the evaluation of cervical masses, particularly in endemic regions. Hydatid disease infestations are best treated with complete excision of the intact cyst.
