Somatosensory Spinal Cord Evoked Potentials in the Evaluation of the Effect of Dexamethasone in Experimental Spinal Cord Injury
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Dosyalar
Tarih
1998
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SPRINGER
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
We studied the effects of high-dose dexamethasone on amplitude and latency values of spinal cord evoked potentials. Thirty-three rabbits were divided into three equal groups. The first group served as the control group, the others received high-dose (2.5 mg/kg) dexamenthasone, the second group I hour prior to and the third group immediately after the induction of a spinal cord trauma in segment T12. The spinal cord evoked potentials were recorded epidurally from T12 segment 5 min before and 5, 30, 60, 90, 120 and 150 min after trauma. Pretreatment with dexamethasone (group II) prevented the latency delay, and later treatment with dexemethasone (group III) prevented the latency delay partially. Our results suggest that when dexamethasone is given prophylactially it prevents latency alteration, while treatment with dexamethasone after lesioning prevents latency alteration partially. From our results we conclude that pretreatment with dexamethasone may involve different mechanisms than were activated in the posttreatment group.
Açıklama
Anahtar Kelimeler
Dexamethasone, Somatosensory Evoked Potential, Spinal Cord Injury
Kaynak
Neurosurgical Review
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
21
Sayı
4
Künye
Güney, Ö., Acar, O., Demir, O., Üstün, M. E., Kocaoğullar, Y., (1998). Somatosensory Spinal Cord Evoked Potentials in the Evaluation of the Effect of Dexamethasone in Experimental Spinal Cord Injury. Neurosurgical Review, 21(4), 265-269. DOI:10.1007/BF01105783
