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Öğe Antibodies against oxidized low density lipoprotein and their clinical importance: Review [Okside düşük lipoprotein otoantikorlari ve klinik önemi](Turkiye Klinikleri, 2005) Kurban S.; Mehmeto?lu I.Atherosclerosis is a multi-factorial disease. It has been demonstrated that low-density lipoproteins (LDL) are modified by free radicals and that this form of LDL is taken up by macrophages more easily. This modification of LDL has been assumed to be the most significant factor in the initiation and progression of atherogenesis. Oxidized low density lipoprotein (Ox-LDL) particles show chemotactic, cytotoxic and immunogenic properties. Ox-LDL expresses a large number of epitopes and cause production of polyclonal autoantibodies against these products. Especially, autoantibodies against apolipoprotein B100 (apoB100) modified by malondialdehyde (MDA) and 4-hydroxynonenal are produced. Ig-OxLDL may thus contribute to the formation of atherosclerosis. Antibodies against Ox-LDL have also been found in many diseases other than atherosclerosis, such as coronary artery disease (CAD), diabetes mellitus (DM), renovascular syndrome, uremia, acute infections, preeclampsia, antiphospholipid syndrome (APS), metabolic syndrome (MS), myocardial infarction (MI) and systemic lupus erythematosus (SLE). These antibodies might play an important role in the pathogenesis and diagnosis of a number of these diseases. However, these antibodies are highly heterogeneous and present information concerning them is quite limited. In this review, we have aimed to evaluate current research regardinging Ox-LDL and its antibodies. Copyright © 2005 by Türkiye Klinikleri.Öğe Effect of alcohol on lipid levels in the brains of rats(2008) Kurban S.; Mehmetoglu I.Purpose: To investigate the effects of alcohol consumption on rat brain cholesterol, triglyceride, and phospholipids levels. Materials and methods: The study was performed on 24 Sprague-Dawley rats of which 12 were selected as the control group and 12 as the alcohol group. Both groups were fed regular laboratory chow. In addition, the alcohol group rats were fed 15% (v/v) of ethanol in their drinking water for 2 months. Then, the rats were decapitated under ketamine anesthesia and the brain tissues were removed and homogenized in ice-cold 0.1 M phosphate buffer containing 1% digitonin. The tissues were centrifuged and brain cholesterol, triglyceride, and phospholipid levels of supernatants were measured using commercially available enzymatic kits. Results: Brain cholesterol, triglyceride, and phospholipid levels of the alcohol group were 29.36 ± 1.68, 39.81 ± 8.5, and 2.91 ± 0.82, respectively, whereas the same parameters of the control group were 22.58 ± 2.29, 32.57 ± 3.7, and 2.47 ± 0.64 mg/g protein, respectively. Brain cholesterol (p<0.001) and triglyceride (p<0.05) levels differed significantly between the groups whereas phospholipid levels did not. Conclusion: The effects of alcohol on brain cholesterol and triglyceride levels may result in significant disturbances in brain functions. The underlying mechanism of this finding is not known and needs to be investigated further.Öğe The effect of alcohol on total antioxidant activity and nitric oxide levels in the sera and brains of rats(2008) Kurban S.; Mehmeto?lu I.Background: The present study investigated the effect of alcohol consumption on total antioxidant activity (AOA) and nitric oxide (NO) levels in the sera and brains of rats. Materials and methods: The study included 24 rats that were divided into 2 groups: the control group (n = 12) and the alcohol group (n = 12). Both groups were fed regular laboratory chow and tap water for a period of 2 months; however, the alcohol group received 15% (v/v) ethanol in their drinking water. Then, the rats were decapitated, and serum and brain AOA and NO levels were measured. Results: Both serum and brain AOA of the alcohol group were significantly lower than those of the control group. Serum NO levels of the alcohol group were significantly higher, whereas brain NO levels were lower, but not significantly, than those of the control group. Conclusion: Our findings show that alcohol diminished both serum and brain defense mechanisms against free radical attack, which might result in many diseases. Moreover, decreased AOA levels in the alcohol group might be a significant cause of increased serum NO levels in this group or vice versa: however, the effects of alcohol on brain NO levels require further investigation. © TÜBİTAK.Öğe Flavonoid contents and antioxidant features of tea, spices and other comestibles of plant origin: Review [Çay, baharat ve bitki kaynakli bazi gida maddelerinin flavonoid i?çerikleri ve antioksidan özellikleri](Turkiye Klinikleri, 2005) Mehmeto?lu I.; Muhteşem Ünlü C.; Gökçe R.; Kurban S.Free radicals and antioxidant balance are important for the maintenance of health in human beings. Various antioxidants (AO) are absorbed with diets of which antioxidant vitamins and flavanoids are principle components. Recently, various significant antioxidants have been discovered and their sources investigated. The most important sources of flavanoids are spices, certain tea types and various vegetables and fruits. Nourishment with foods containing high amounts of flavanoids may provide protection against a group of diseases including cancer, diabetes mellitus, aging, cardio- and cerebral-vascular diseases. In the present review, our aim was to evaluate flavanoid content and antioxidant AO properties of teas, spices and other frequently consumed foods. Copyright © 2005 by Türkiye Klinikleri.Öğe Investigation of serum homocysteine and coenzyme Q10 (CoQ10) levels in patients with essential hypertension [Esansiyel hipertansiyon hastalarinda serum koenzim Q10 (CoQ 10) ve homosistein düzeylerinin araştirilmasi](2010) Şanlitürk Ş.; Mehmeto?lu I.; Kurban S.; Yazici M.Objective: Coenzyme Q10 (CoQ10, ubikinon) the only lipid soluble antioxidant synthesized endogenously, prevents the generation of free radicals as well as oxidative modifications of proteins, lipids, and DNA. Also, CoQ10 is as an electron carrier in the mitochondrial respiratory chain. Decreased levels of CoQ10 in humans are observed in many pathologies such as cardiac disorders, neurodegenerative diseases. Homocysteine is a naturally occuring, sulfur containing amino acid and elevated serum homocysteine levels is an independent risk factor for cardiovascular disease. In this study we have aimed to investigate the roles of homocysteine and CoQ10 levels in essential hypertension. Material and Methods: The study was performed on 30 patients (10 M, 20 F) with essential hypertension aged 38-79 years (57.23 ± 10.68) and 30 healty controls (12 M, 18 F) aged 38-83 years (56.50 ± 11.36). Fasting serum homocysteine and CoQ 10 levels of the subjects were measured by HPLC (high performance liquid chromatography) method. Results: Homocysteine levels of the patients with essential hypertension (17.35 ± 4.81 ?mol/L) were found significantly higher (p< 0.01) than that of the controls (11.16 ± 3.18 ?mol/L), while CoQ10 levels of the patients were (801.22 ± 285.91 ?g/L) slightly but not significantly lower than those of the controls (810.07 ± 278.63 ?g/L). Conclusion: It was concluded that high serum homocysteine levels may plays a role in the pathogenesis of essential hypertension whereas there was no contribution of CoQ10 levels to the pathogenesis of this disease. Copyright © 2010 by Türkiye Klinikleri.Öğe Investigation of the relationships of obesity with melatonin and dehydroepiandrosterone levels [Melatonin ve dehidroepiandrosteron düzeylerinin obezite ile ilişkilerinin araştirilmasi](Nobelmedicus, 2017) Mehmetoğlu İ.; Gökçe S.; Kurban S.; Gökçe R.; Atalar M.N.; Çelik M.Objective: Melatonin is synthesized in pineal gland and plays a role in energy metabolism and the weight-reducing effects. Dehydroepiandrosterone (DHEA) is synthesized primarily by the zona reticularis of adrenal cortex and to a lesser degree by the gonads. DHEA has antioxidant, antilipidperoxidative, antiinflammatory, antiatherogenic, antiaging and weight-reducing or preventing effects. Our aim of this study was to investiagate blood DHEA, melatonin, insulin resistance (IR) and lipids levels and correlations between them in obese and nonobese subjects. Material and Method: The study was performed on 33 obese subjects ((16 male (M), 17 female (F)) aged 40.03±8.47 years and 33 normal weight healty controls (15M, 18F) aged 28.76±6.22 years. In both groups, DHEA, melatonin, IR, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and total cholesterol and triglyceride levels and correlations between them were investigated. DHEA and melatonin levels were determined by ELISA method and insulin, fasting blood glucose levels and lipid parameters were determined by rutin method using commercially avilable kits. IR was calculated using a formula. Results: There was no statistically significant differences between DHEA and melatonin levels of the groups and there were no correlations between them in both groups. However, there was a significant negative correlation between DHEA and triglyceride levels in the obese group (r=-0.342, p<0.05). Conclusion: Our results show that DHEA and melatonin levels were not changed in obesity and they have no effects on IR. However significant negative correlation between DHEA and triglyceride levels in obese subjects needs to be more investigated in terms of the effect of DHEA on adipose tissue and obesity. © 2017, Nobelmedicus. All rights reserved.Öğe The role of ischemia modified albumin in the evaluation of hemodynamic changes in the splanchnic area during laparoscopic cholecystectomy [Laparoskopik kolesistektomi süresince splanknik sahadaki hemodinamik de?işikliklerin de?erlendirilmesinde iskemi modifiye albuminin rolü](2010) Köksal H.; Kurban S.; Şahin M.Purpose: Elevation of intraabdominal pressure by means of gas insufflation produces hemodynamic disturbances in the peritoneal viscera, leading to splanchnic ischemia. Recently, ischemia modified albumin (IMA) has been used to investigate conditions such as myocardial and skeletal muscle ischemia. The purpose of this clinical investigation is to determine the role of IMA in the evaluation of alterations in blood flow of the splanchnic area and abdominal viscera during laparoscopic cholecystectomy. Patients and Methods: Twenty two patients (F/M: 21/1) undergoing laparoscopic cholecystectomy (Group I) and 10 patients (F/M: 7/3) undergoing various surgical procedures under general an- estheasia (Group II) were studied. No patient had any cardiovascular disease. Blood samples for IMA were collected at preoperative and intraoperative periods. A rapid, colorimetric assay was used to measure serum IMA levels. Results: In Group I, the preoperative and intraoperative IMA levels were 0.59±0.16 absorbance units (ABSU) and 0.74±0.17 ABSU, respectively. The intraoperative IMA levels were higher than the preoperative levels (p=0.025). In Group II, the preoperative and intraoperative IMA levels were 0.43±0.12 ABSU and 0.52±0.15 ABSU, respectively. The difference was not statistically significant (p=0.22). The intraoperative IMA levels in Group I were higher than Group II (p=0.003).Conclusion: IMA, a new sensitive marker for ischemia, can be helpful for determining alterations in blood flow of the splanchnic area and abdominal viscera during laparoscopic cholecystectomy. cholecystectomy, splanchnic area.
