Effect of alcohol on lipid levels in the brains of rats
Küçük Resim Yok
Tarih
2008
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: To investigate the effects of alcohol consumption on rat brain cholesterol, triglyceride, and phospholipids levels. Materials and methods: The study was performed on 24 Sprague-Dawley rats of which 12 were selected as the control group and 12 as the alcohol group. Both groups were fed regular laboratory chow. In addition, the alcohol group rats were fed 15% (v/v) of ethanol in their drinking water for 2 months. Then, the rats were decapitated under ketamine anesthesia and the brain tissues were removed and homogenized in ice-cold 0.1 M phosphate buffer containing 1% digitonin. The tissues were centrifuged and brain cholesterol, triglyceride, and phospholipid levels of supernatants were measured using commercially available enzymatic kits. Results: Brain cholesterol, triglyceride, and phospholipid levels of the alcohol group were 29.36 ± 1.68, 39.81 ± 8.5, and 2.91 ± 0.82, respectively, whereas the same parameters of the control group were 22.58 ± 2.29, 32.57 ± 3.7, and 2.47 ± 0.64 mg/g protein, respectively. Brain cholesterol (p<0.001) and triglyceride (p<0.05) levels differed significantly between the groups whereas phospholipid levels did not. Conclusion: The effects of alcohol on brain cholesterol and triglyceride levels may result in significant disturbances in brain functions. The underlying mechanism of this finding is not known and needs to be investigated further.
Açıklama
Anahtar Kelimeler
Brain, Cholesterol, Ethanol, Phospholipids, Rat 2, Triglyceride
Kaynak
Gazi Medical Journal
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
19
Sayı
4
