Effect of alcohol on lipid levels in the brains of rats

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dc.contributor.authorKurban S.
dc.contributor.authorMehmetoglu I.
dc.date.accessioned2020-03-26T17:28:51Z
dc.date.available2020-03-26T17:28:51Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: To investigate the effects of alcohol consumption on rat brain cholesterol, triglyceride, and phospholipids levels. Materials and methods: The study was performed on 24 Sprague-Dawley rats of which 12 were selected as the control group and 12 as the alcohol group. Both groups were fed regular laboratory chow. In addition, the alcohol group rats were fed 15% (v/v) of ethanol in their drinking water for 2 months. Then, the rats were decapitated under ketamine anesthesia and the brain tissues were removed and homogenized in ice-cold 0.1 M phosphate buffer containing 1% digitonin. The tissues were centrifuged and brain cholesterol, triglyceride, and phospholipid levels of supernatants were measured using commercially available enzymatic kits. Results: Brain cholesterol, triglyceride, and phospholipid levels of the alcohol group were 29.36 ± 1.68, 39.81 ± 8.5, and 2.91 ± 0.82, respectively, whereas the same parameters of the control group were 22.58 ± 2.29, 32.57 ± 3.7, and 2.47 ± 0.64 mg/g protein, respectively. Brain cholesterol (p<0.001) and triglyceride (p<0.05) levels differed significantly between the groups whereas phospholipid levels did not. Conclusion: The effects of alcohol on brain cholesterol and triglyceride levels may result in significant disturbances in brain functions. The underlying mechanism of this finding is not known and needs to be investigated further.en_US
dc.identifier.endpage171en_US
dc.identifier.issn1300056Xen_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage168en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22863
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofGazi Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBrainen_US
dc.subjectCholesterolen_US
dc.subjectEthanolen_US
dc.subjectPhospholipidsen_US
dc.subjectRat 2en_US
dc.subjectTriglycerideen_US
dc.titleEffect of alcohol on lipid levels in the brains of ratsen_US
dc.typeArticleen_US

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