Investigation of serum homocysteine and coenzyme Q10 (CoQ10) levels in patients with essential hypertension [Esansiyel hipertansiyon hastalarinda serum koenzim Q10 (CoQ 10) ve homosistein düzeylerinin araştirilmasi]
Küçük Resim Yok
Tarih
2010
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Coenzyme Q10 (CoQ10, ubikinon) the only lipid soluble antioxidant synthesized endogenously, prevents the generation of free radicals as well as oxidative modifications of proteins, lipids, and DNA. Also, CoQ10 is as an electron carrier in the mitochondrial respiratory chain. Decreased levels of CoQ10 in humans are observed in many pathologies such as cardiac disorders, neurodegenerative diseases. Homocysteine is a naturally occuring, sulfur containing amino acid and elevated serum homocysteine levels is an independent risk factor for cardiovascular disease. In this study we have aimed to investigate the roles of homocysteine and CoQ10 levels in essential hypertension. Material and Methods: The study was performed on 30 patients (10 M, 20 F) with essential hypertension aged 38-79 years (57.23 ± 10.68) and 30 healty controls (12 M, 18 F) aged 38-83 years (56.50 ± 11.36). Fasting serum homocysteine and CoQ 10 levels of the subjects were measured by HPLC (high performance liquid chromatography) method. Results: Homocysteine levels of the patients with essential hypertension (17.35 ± 4.81 ?mol/L) were found significantly higher (p< 0.01) than that of the controls (11.16 ± 3.18 ?mol/L), while CoQ10 levels of the patients were (801.22 ± 285.91 ?g/L) slightly but not significantly lower than those of the controls (810.07 ± 278.63 ?g/L). Conclusion: It was concluded that high serum homocysteine levels may plays a role in the pathogenesis of essential hypertension whereas there was no contribution of CoQ10 levels to the pathogenesis of this disease. Copyright © 2010 by Türkiye Klinikleri.
Açıklama
Anahtar Kelimeler
Coenzyme Q10, Homocysteine, Hypertension
Kaynak
Turkiye Klinikleri Cardiovascular Sciences
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
22
Sayı
3
