Investigation of serum homocysteine and coenzyme Q10 (CoQ10) levels in patients with essential hypertension [Esansiyel hipertansiyon hastalarinda serum koenzim Q10 (CoQ 10) ve homosistein düzeylerinin araştirilmasi]

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dc.contributor.authorŞanlitürk Ş.
dc.contributor.authorMehmeto?lu I.
dc.contributor.authorKurban S.
dc.contributor.authorYazici M.
dc.date.accessioned2020-03-26T18:05:43Z
dc.date.available2020-03-26T18:05:43Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Coenzyme Q10 (CoQ10, ubikinon) the only lipid soluble antioxidant synthesized endogenously, prevents the generation of free radicals as well as oxidative modifications of proteins, lipids, and DNA. Also, CoQ10 is as an electron carrier in the mitochondrial respiratory chain. Decreased levels of CoQ10 in humans are observed in many pathologies such as cardiac disorders, neurodegenerative diseases. Homocysteine is a naturally occuring, sulfur containing amino acid and elevated serum homocysteine levels is an independent risk factor for cardiovascular disease. In this study we have aimed to investigate the roles of homocysteine and CoQ10 levels in essential hypertension. Material and Methods: The study was performed on 30 patients (10 M, 20 F) with essential hypertension aged 38-79 years (57.23 ± 10.68) and 30 healty controls (12 M, 18 F) aged 38-83 years (56.50 ± 11.36). Fasting serum homocysteine and CoQ 10 levels of the subjects were measured by HPLC (high performance liquid chromatography) method. Results: Homocysteine levels of the patients with essential hypertension (17.35 ± 4.81 ?mol/L) were found significantly higher (p< 0.01) than that of the controls (11.16 ± 3.18 ?mol/L), while CoQ10 levels of the patients were (801.22 ± 285.91 ?g/L) slightly but not significantly lower than those of the controls (810.07 ± 278.63 ?g/L). Conclusion: It was concluded that high serum homocysteine levels may plays a role in the pathogenesis of essential hypertension whereas there was no contribution of CoQ10 levels to the pathogenesis of this disease. Copyright © 2010 by Türkiye Klinikleri.en_US
dc.identifier.endpage288en_US
dc.identifier.issn1306-7656en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage284en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25516
dc.identifier.volume22en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurkiye Klinikleri Cardiovascular Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCoenzyme Q10en_US
dc.subjectHomocysteineen_US
dc.subjectHypertensionen_US
dc.titleInvestigation of serum homocysteine and coenzyme Q10 (CoQ10) levels in patients with essential hypertension [Esansiyel hipertansiyon hastalarinda serum koenzim Q10 (CoQ 10) ve homosistein düzeylerinin araştirilmasi]en_US
dc.typeArticleen_US

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