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Öğe 3 ', 4 '-dihydroxyflavonol attenuates tissue damage in unilateral testis ischemia-reperfusion in rats(COMENIUS UNIV, 2015) Duman, A.; Mogulkoc, R.; Baltaci, A. K.; Menevse, E.The purpose of this study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on oxidative damage and antioxidant system in experimental testicular torsion-detorsion. The study included 60 male Wistar albino rats. Study groups were formed as follows: 1. Control; 2. Sham; 3. 720 degrees - 4 hours torsion; 4. 720 degrees - 4 hours torsion + 4 hours detorsion; 5. 720 degrees - 4 hours torsion + DiOHF; 6. 720 degrees - 4 hours torsion + DiOHF + 4 hours detorsion; 7. 720 degrees - 4 hours torsion + 24 hours detorsion; 8. 720 degrees - 4 hours torsion + DiOHF + 24 hours detorsion. Testis were collected for the analysis of glutathione peroxidase (GPx), nitric oxide (NO), malondialdehyde (MDA), glutathione (GSH), and xanthine oxidase (XO). GPx in the Group 8 were higher than the values in the other groups (p < 0.001). Concerning NO, the groups 3, 4, and 7 were found to have higher values than other groups (p < 0.001). MDA levels were higher in the groups 3, 7, and 8, when compared to the levels in other groups (p < 0.001). When tissue GSH levels were examined, the Group 5 had the highest GSH values (p < 0.001). With regard to XO values, the groups 3, 4, and 7 had the highest XO values (p < 0.001). The results of the study indicated that intraperitoneal DiOHF inhibited increased lipid peroxidation in testis ischemia-reperfusion injury in rats (Tab. 5, Ref. 46). Text in PDF www.elis.sk.Öğe Both experimental hypothyroidism and hyperthyroidism increase cardiac irisin levels in rats(COMENIUS UNIV, 2018) Atici, E.; Menevse, E.; Baltaci, A. K.; Mogulkoc, R.Irisin is a newly discovered myokine and adipokine that increases total body energy expenditure. The aim of this study was to determine the effect of experimental hypothyroidism and hyperthyroidism on the levels of irisin in heart tissue in rats. The study was performed on the 40 male Sprague-Dawley rats. Experimental groups were designed as; Control, Hypothyroidism, Hypothyroidism+L-Thyroxine, Hyperthyroidism and Hyperthyroidism + PTU. Following 3 weeks experimental period, irisin levels were determined in heart tissues. Hypothyroidism group values of irisin were higher than in the control group, but lower than in the hyperthyroidism group. The hyperthyroidism group had the highest levels of cardiac irisin. The results of the study showed that the experimental hypothyroidism and hyperthyroidism increased the heart irisin levels, but the increase in the hyperthyroidism group was much higher than in the hypothyroidism group. However, treatment of hypothyroidism and hyperthyroidism corrected cardiac irisin levels (Fig. 1, Ref. 28).Öğe The effect of acute swimming exercise on plasma leptin in rats(COMENIUS UNIV, 2012) Baltaci, A. K.; Vurucu, N.; Uzun, A.; Mogulkoc, R.; Kilic, M.Exercise is known to increase free fatty acid and glucose metabolism. In consideration of such physiological effects of leptin such as reducing food intake and increasing energy consumption, many researchers have studied the relation between leptin and exercise. Despite the inconsistency between results, it is generally accepted that physical activity causes changes in leptin secretion. The present study aims to determine the changes that occur in plasma leptin levels of the rats subjected to acute swimming exercise, immediately after exercise, and in the 24th and 48th hours following exercise. Forty adult male rats of Sprague Dawley species were equally allocated to 4 groups. Group 1: General Control Group. Group 2: Swimming Group, the group that was decapitated just after 30-minutes of acute swimming exercise. Group 3: Swimming Group, the group that was decapitated 24 hours after 30-minutes of acute swimming exercise. Group 4: Swimming Group, the group that was decapitated 48 hours after 30-minutes of acute swimming exercise. Plasma leptin levels of the experimental animals were determined according to RIA method in the blood samples collected by decapitation method. Comparison of plasma leptin levels between groups revealed that the Group 3 had the highest plasma leptin levels (p < 0.01). Plasma leptin levels in the Group 1 (control) and 4 were not different and the Group 2 had the lowest plasma leptin levels (p < 0.01). Results of the present study show that an acute swimming exercise and/or stress factors associated with an acute exercise inhibit leptin secretion from the adipose tissue (Tab. 1, Ref. 21). Full Text in PDF www.elis.sk.Öğe The effect of acute swimming exercise on plasma melatonin levels in rats(COMENIUS UNIV, 2012) Uzun, A.; Baltaci, A. K.; Kilic, M.; Mogulkoc, R.Background: This study aims to determine the changes in plasma melatonin levels of rats performing acute swimming exercise, immediately following the exercise and after 24 and 48 hours. Methods: The study included 40 Sprague Dawley species adult male rats divided in to 4 groups as follows: group 1: general control group, group 2: swimming group A, the animales were decapitated after performing 30-minute acute swimming exercise, group 3: sSwimming group B, the animals were decapitated 24 hours after performing 30-minute acute swimming exercise and group 4: swimming group C, the animals were decapitated 48 hours after performing 30-minute acute swimming exercise. Blood samples were collected from all experimental animals by decapitation method and plasma melatonin levels were determined according to RIA method. Results: The comparison of plasma melatonin levels among groups revealed that group 3 had the highest plasma melatonin levels (p<0.01). The levels in group 1 (control) and group 4 were not different. The lowest plasma melatonin levels were found in group 2 (p<0.01). Conclusion: The results of our study demonstrate that plasma melatonin levels that decrease immediately after acute swimming exercise increase significantly after 24 hours and restore to resting levels after 48 hours (Tab. 1, Ref. 15). Full Text in PDF www.elis.sk.Öğe Effect of boron supplementation on plasma element distribution in ovariectomized rats subjected to acute swimming exercise(COMENIUS UNIV, 2011) Yazici, Z.; Baltaci, A. K.; Mogulkoc, R.; Halifeoglu, I; Kaya, Y.Background: This study aims to examine how boron supplementation affects distribution of elements in the plasma of rats whose ovaries were removed and who were subjected to swimming exercise. Methods: The study included 80 Sprague-Dawley type female rats, which were equally allocated to 8 groups. Group 1: General control, Group 2: Exercise control; Group 3: Ovariectomized control, Group 4: Ovariectomized exercise, Group 5: IP (intraperitoneal) boron-supplemented control, Group 6: IP boron-supplemented exercise, Group 7: Ovariectomized, IP boron-supplemented exercise, group 8: Ovariectomized, IP boron-supplemented. Following the exercise, blood samples were collected from all animals by decapitation, and analyzed in terms of plasma copper, iron, phosphorus, magnesium, calcium, and zinc using an atomic absorption spectrophotometer. Results: Groups 1 and 5 had the lowest copper (p<0.01) and the highest zinc and calcium (p<0.01) levels, in comparison to other groups. Phosphorus levels in groups 3, 5 and 8 were significantly lower than those in other groups (p<0.01). Magnesium levels in groups 3, 5 and 8 were higher, relative to the levels in other groups (p<0.01). Conclusion: Results of the study indicate that acute swimming exercise in ovariectomized rats supplemented with boron leads to significant modifications in the distribution of some trace elements in the plasma. It can be emphasized as a separate result of this study that changes in copper, zinc and calcium levels were independent of boron supplementation (Tab. 2, Ref. 14). Full Text in free PDF www.bmj.sk.Öğe Effect of L-thyroxime induced hyperthyroidism on lipid peroxidation in testis and kidney tissues of rats(INDIAN VETERINARY JOURNAL, 2007) Baltacl, A. K.; Mogulkoc, R.; Oztekin, E.In vivo and in vitro studies point out that thyroid hormones have an important role in oxidative stress (Karbownik and Lewinski 2003). Thyroid hormones act on the mitochondria by regulating the energy metabolism (Goglia et al., 2002). High concentrations of thyroid hormones affect oxygen metabolism and stimulate formation of free radicals in mitochondria (Sewerynek et al., 1999). It was shown that not only hyperthyroidism, but also hypothyroidism caused changes in oxidant and antioxidant systems (Berzinska-Slebodzinska 2001, Sewerynek et al., loc. cit). Hypermetabolic condition in hyperthyroidism was associated with an increase in free radical formation and lipid peroxide levels (Venditti et al., 1997). it was established in a study carried out on hypothyroid rats that there was an increase in protein carbonyl and hydrogen peroxide in testis homogenates. However, it was noted that triiodothyronine administration did not change hydrogen peroxide in these subjects, but further increased protein carbonyl content (Choudhury et al., 2003). Studies investigating the effect of thyroxine administration on oxidative stress in different organs showed that damage in the kidneys was more than the damage in the liver (Beckett et al., 1986). The present study was carried out to determine how experimental hyperthyroidism induced by L-thyroxin affects lipid peroxidation in both testis and kidney tissues of rats.Öğe Effect of Pinealectomy and Melatonin Supplementation on Metallothionein, Zinc Transport Protein Levels in the Small Intestine Sections of the Rat(WILEY, 2017) Unal, O.; Baltaci, A. K.; Mogulkoc, R.; Avunduk, M. C.[Abstract not Available]Öğe The effect of pinealectomy on plasma vasopressin response to isotonic, hypertonic and hypovolemic treatments in rats supplemented with L-thyroxine(AKADEMIAI KIADO, 2008) Mogulkoc, R.; Baltaci, A. K.The present study was conducted to determine the effects of basal, isotonic as well as hypertonic and hypovolemic treatments on fluid-electrolyte balance and plasma AVP levels in rats supplemented with L-thyroxine and pinealectomized L-thyroxine. The animals were initially separated into 4 groups: control (n = 24), L-thyroxine treated (n = 24); L-thyroxine + sham-pinealectomy (n = 24) treated and 4-L-thyroxine + pinealectomy (n = 24) treated. L-thyroxine was given for 4 weeks. At the end of the 4-week experimental period, the sub-groups were formed before decapitation, which were classified as unstimulated (n = 6), isotonic (n = 6), hypertonic (n = 6) and hypovolemic (n = 6) stimulation. Plasma AVP, total triiodothyronine (TT3) and total thyroxine (TT4) levels were examined in plasma by RIA. Hematocrit and osmolality levels were also determined. It was found that the TT3 and TT4 levels showed significant increases in L-thyroxine treated groups (P < 0.001). Also, plasma AVP levels increased in the group subjected to L-thyroxine treatment. However, this increase was depicted to be significantly more prominent in L-thyroxine + pinealectomy treated group (P < 0.001). The results of the present study indicate that L-thyroxine treatment increases the basal and stimulated AVP release, which became more significant in the pinealectorny plus L-thyroxine treatment group. Moreover, the results indicate that AVP response to hypertonic and hypovolemic stimulations does not undergo any change due to supplementation by L-thyroxine treatment and/or pinealectomy plus L-thyroxine.Öğe Effect of Resveratrol Application on Lipid Peroxidation in Experimental Renal Ischemia-Reperfusion Injury in Rats(WILEY, 2017) Baltaci, A. K.; Gokbudak, H.; Mogulkoc, R.; Avunduk, M. C.; Menevse, E.[Abstract not Available]Öğe The Effect of Resveratrol Supplementation on Element Metabolism in Bone Tissue of Rats with Acute Swimming Exercise(WILEY, 2017) Baltaci, A. K.; Cinarli, D.; Mogulkoc, R.; Patlar, S.; Baltaci, S. B.[Abstract not Available]Öğe Effect of vitamin C supplementation on various elements in elite taekwondo players(EDIZIONI MINERVA MEDICA, 2012) Patlar, S.; Boyali, E.; Baltaci, A. K.; Mogulkoc, R.; Gunay, M.Aim. Nutrition of elite athletes is important for their performance, as well as physical and mental functions. Long-term vitamin deficiency is known to lead to a decrease in the performance of athletes. The present study aims to examine the effects of vitamin C supplementation on the distribution of some elements in the serum of individuals engaged in taekwondo. Methods. The study registered 7 male elite taekwondo players, whose mean age was 21.56 +/- 0.28 years, mean weight was 65.67 +/- 2.07 (kg) and mean duration of involvement in sports was 10-12 years. Subjects in the study were supplemented with 300 mg oral vitamin C (L-ascorbic acid) for 6 weeks. Resting blood samples collected from all subjects twice, once before and once after supplementation, were analyzed to find out serum levels of cobalt, boron, cadmium, chromium, nickel, manganese, molybdenum, copper, iron, zinc, phosphorus, sodium, potassium and calcium (mg/L), using an atomic emission device. Result. Six-week vitamin C supplementation brought about a significant decrease in boron and potassium levels (p < 0.001) and an increase in iron levels (p < 0.001). Other parameters analyzed were not affected by vitamin C supplementation. Conclusions. The results of research have show that C vitamin supplementation in male taekwondo sportmen affects especially iron and boron metabolism, but has limited affects on serum levels of the other elementsÖğe Effects of pinealectomy and melatonin and steroids supplementation on leptin levels in ovariectomized rats(2009) Oztekin, Esma; Mogulkoc, R.; Baltacı, A.K.; Tiftik, A.M.The present study was aimed at finding out the relative effects of melatonin and sex steroids on leptin concentrations in ovariectomized rats. This study shows that pinealectomy in ovariectomized rats leads to a significant increase in leptin levels. Estradiol and progesterone supplementation in pinealectomized and ovariectomized rats partly reversed the increase in leptin. Melatonin supplementation completely reversed the increase in leptin.Öğe The effects of resveratrol administration on lipid oxidation in experimental renal ischemia-reperfusion injury in rats(TAYLOR & FRANCIS LTD, 2019) Baltaci, A. K.; Gokbudak, H.; Baltaci, S. B.; Mogulkoc, R.; Avunduk, M. C.We investigated how resveratrol affects lipid oxidation during experimental renal ischemia-reperfusion injury in rats. We used 48 adult male rats assigned to five groups: group 1, control; group 2, renal ischemia; group 3, renal ischemia + reperfusion; group 4, resveratrol + renal ischemia; group 5, resveratrol + renal ischemia + reperfusion. Plasma and renal tissue malondialdehyde (MDA), and erythrocyte and renal tissue glutathione (GSH) levels were measured and histologic changes in the renal tissue were examined. Ischemia-reperfusion affected the MDA-GSH balance adversely and caused histopathological changes in the renal tissue of the ischemia and ischemia + reperfusion groups. Resveratrol treatment normalized MDA and GSH levels as well as the histopathology that occurred in the renal tissue of the ischemia and ischemia + reperfusion groups.Öğe The Effects of Thyroid Dysfunction on Nesfatin-1 Levels in Rats(WILEY, 2017) Atici, E.; Menevse, E.; Baltaci, A. K.; Mogulkoc, R.[Abstract not Available]Öğe The effects of Zinc and Melatonin on Muscle Ischemia-Reperfusion Damage in Rat(WILEY, 2017) Celer, M.; Mogulkoc, R.; Baltaci, A. K.; Dasdelen, D.[Abstract not Available]Öğe Effects of Zinc and Melatonin Supplements on Immunity Parameters of Rats with Breast Cancer(WILEY, 2017) Baltaci, S. B.; Mogulkoc, R.; Baltaci, A. K.; Emsen, A.; Artac, H.[Abstract not Available]Öğe Experimental Hypothyroidism and Hyperthyroidism Have Similar Affects on Cardiac Irisin Levels in Rats(WILEY, 2017) Atici, E.; Menevse, E.; Baltaci, A. K.; Mogulkoc, R.[Abstract not Available]Öğe Histological effects of zinc and melatonin on rat testes(COMENIUS UNIV, 2011) Tuncer, I; Sunar, F.; Toy, H.; Baltaci, A. K.; Mogulkoc, R.Background: The objective of this study is to examine the histological effects of zinc and melatonin, alone or in combination, on rat testes. Methods: For this purpose four study groups of ten Sprague-Dawley male rats were formed and treated for one month as follows: (1) Controls; (2) Rats injected with 3 mg/kg/day zinc, as zinc sulfate; (3) Rats injected with 3 mg/kg/day melatonin and (4) Rats injected with 3 mg/kg/day each zinc and melatonin. Results: After four weeks the rats treated with melatonin showed inhibited spermatogenesis, testicular tubular degeneration and necrosis, obstruction of tubular lumen and lymphocytic infiltration. The two zinc-treated groups showed no histological differences to controls but the melatonin-only group showed inhibited spermatogenetic activity, tubular degeneration and necrosis, as well as obstruction of tubule lumens and lymphocytic infiltration. Conclusion: The obtained results suggest that 4-week treatment with melatonin leads to histological and physiological impairments of testis and that zinc supplementation might offset these damaging effects (Tab. 2, Fig. 4, Ref. 12). Full Text in free PDF www.bmj.sk.Öğe The influence of estradiol and progesterone and melatonin supplementation on TNF-alpha levels in ovariectomized and pinealectomized rats(AKADEMIAI KIADO, 2006) Oztekin, Esma; Mogulkoc, R.; Baltaci, A. K.; Tiftik, A. A.The aim of this study was to investigate the effect of estradiol and progesterone and melatonin supplementation on TNF-alpha levels in ovariectomized and pinealectomized rats. The study was carried out on 42 adult, Spraque-Dawley strain female rats aged 6 months and weighing 200-250 grams. The rats were divided into 6 groups, each group contained 7 rats. Group 1: Sham-ovariectomized (Sham-Ovx), Group 2: Ovariectomized (Ovx), Group 3: Ovx and estradiol (E) and progesterone (P) supplemented (Ovx+E-P) group, Group 4: Ovx+E-P+Melatonin (M) supplemented group, Group 5: Ovx Pinealectomized (Pnx) group, Group 6: Ovx - Pnx+E-P supplemented group. Serum TNF-alpha levels were determined after 4 weeks application period. Group 6 (Ovx-Pnx+E-P) has the highest serum TNF-alpha compared with other groups while group 2 (ovariectomized), has the lowest levels (P < 0.001). Group 5 was higher than groups 1, 2, 3 and 4 (P < 0.001). The results of the study show that ovariectomy reduces the serum level of TNF-alpha, but estradiol and progesterone application prevents this reduction in ovariectomized rats. However, pinealectomy intensifies the increases in TNF-alpha levels in ovariectomized and estradiol and progesterone supplemented rats, whereas melatonin reduces TNF-alpha levels in ovariectomized rats.Öğe Investigation of Serum Leptin Levels and Vo2max Value in Trained Young Male Athletes and Healthy Males(2005) Unal, M.; Unal, D. O.; Baltacı, Abdulkerim Kasım; Mogulkoc, R.The present study aimed at investigating serum leptin levels of elite young male athletes who have been regularly exercising for a long period of time and males who do not exercise The study included 24 trained young male athletes and 22 healthy sedentary male subjects. Athletes who participated in the study were from different sports branches and have been regularly exercising for at least 2 years. Serum leptin levels were determined by RIA. VO2max levels were identified during maximal exercise. Lactic acid levels were identified one minute before and one minute after exercise from the fingertip by Pro-lactate kit. As a result of the tests, although BMI values of trained young male athletes and healthy males were close to each other, leptin levels were significantly lower (p<0.01), VO2max values were significantly higher (p<0.01) and test periods were significantly longer (p<0.001) in the former. In conclusion, regular exercise, by reducing body fat percentage, suppresses serum leptin levels.
