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Öğe Effect of 3 '-4 '-dihydroxyflavonol on lipid per oxidation in experimental renal ischemia-reperfusion in rats(UNIV KARACHI, 2019) Koç, Aynur.; Ergene, Neyhan.; Baltaci, Abdulkerim Kasim.; Mogulkoc, Rasim.This study aimed to examine the affects of 3'-4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental renal ischemia-reperfusion. The research was conducted on Wistar-albino type male rat. The experimental groups were formed as 1.Control; 2.Sham; 3.Ischemia; 4.Ischemia+reperfusion; 5.DiOHF+Ischemia; 6.Ischemia+ DiOHF + reperfusion. The highest tissue glutathione levels were found in groups 5 and 6. Groups 1 and 2, which were control and sham groups respectively, had the lowest tissue GSH values. Ischemia group was found to have the highest tissue malondialdehyde (MDA) level. Tissue MDA levels in group 4 were lower than those in group 3, however, higher than the levels in all other groups. Erythrocyte GSH levels in groups 5 and 6 were higher than the levels in all other groups. Group 4 has highest plasma MDA values. Plasma MDA levels in group 3 were lower than the levels in Group 4, but higher than those in other groups. The results of the study indicate that intraperitoneal DiOHF administration inhibits lipid per oxidation that intensifies in the case of renal ischemia-reperfusion injury in rats.Öğe Effect of resveratrol administration on muscle glycogen levels in rats subjected to acute swimming exercise(C M B ASSOC, 2019) Bicer, Mursel.; Baltaci, Saltuk Bugra.; Mogulkoc, Rasim.; Baltaci, Abdulkerim Kasim.; Avunduk, Mustafa Cihat.The present study aims to examine how resveratrol administration affects muscle glycogen levels in rats subjected to an acute swimming exercise bout. The study was conducted on adult male rats of Wistar-Albino. The 28 rats used in the study were equally divided among four groups: Group 1, Control Group: The group fed on a standard diet and not subjected to any procedure. Group 2, Control Swimming Group: The group fed on a standard diet and subjected to an acute swimming exercise bout for 30 minutes at the end of the study. Group 3, Resveratrol Group: The group fed on a standard diet and given (10 mg/kg) resveratrol in drinking water for four weeks. Group 4, Resveratrol Swimming Group: The group fed on a standard diet, given (10 mg/kg) resveratrol in drinking water for four weeks and subjected to a 30-minute acute swimming exercise at the end of the study. At the end of the four weeks, the animals were decapitated, muscle glycogen levels using immunohistochemical method. The highest muscle glycogen levels were obtained in the resveratrol-administered Group 3 and the lowest levels in group 2 (swimming group) (p<0.05). The results of the study demonstrate that resveratrol support had a protective and/or regulatory effect on mucle glycogen in both exercised and not-exercised rats.Öğe The effect of thyroid dysfunction and treatment on fat tissue adiponectin levels in rats(BIOINTERFACE RESEARCH APPLIED CHEMISTRY, 2019) Atici, Emine.; Mogulkoc, Rasim.; Baltaci, Abdulkerim Kasim.; Menevse, Esma.Adipose tissue is a hormonal active system that produces and releases leptin, adiponectin and resistin. Seen from this aspect, it may be thought that adiponectin may interact with the thyroid axis. Thyroid function disturbance led to changes on the body weight, muscle volume and adipose tissue. Experimental findings show that adiponectin and thyroid hormones have biological interactin with each other. However, various results have been reported a relationship between thyroid hormones and adiponection levels. The aim of the present study was to determine adipose tissue adiponectin levels in rats with thyroid dysfunction and after treatment. Study was performed on 40 Sprague-Dawley male rats. Groups were designed as 1-control, 2-hypothyroidism (Hypo), 3-hypothyroidism + Thyroxine, 4-hyperthyroidism (Hyper), 5-hyperthyroidism + PTU. At the end of 3 weeks experimental period, adipose tissues of rats were analyed for adiponection by Elisa. Experimental hypothyroidism reduced adipose tissue adiponectin levels, but hyperthyrodism increased. Treatment of hypothyroidism and hyperthyroidism corrected disrupted adiponectin levels to control. The results of the present study show that experimental thyroid dysfunction has affected adipose tissue adiponection levels in rats.Öğe Effects of zinc supplementation on metallothionein levels in ischemic renal tissue(TAYLOR & FRANCIS LTD, 2020) Yazgan, Betul.; Baltaci, Abdulkerim Kasim.; Mogulkoc, Rasim.; Avunduk, Mustafa Cihat.We investigated how zinc (Zn) supplementation affects metallothionein levels in the cortex and medulla of ischemic renal tissue of rats. We used adult male rats divided into four groups: group 1, untreated control; group 2, sham-operated; group 3, ischemia-reperfusion; group 4, ischemia-reperfusion + 5 g/kg Zn. Renal tissue was analyzed using immunostaining of rat metallothionein. Cells stained with metallothionein were counted and their percentage was calculated. We found that the Zn supplemented ischemia and reperfusion group exhibited a greater percentage of cells stained strongly for metallothionein in the renal cortex than all other groups. In the renal medulla, percentages of weak staining for metallothionein in the control and ischemia and reperfusion groups were greater than those in the sham and Zn-supplemented ischemia/reperfusion groups. Our findings indicate that the main effect of Zn in the renal tissue occurs in the cortex, while metallothionein synthesis in the renal medulla is unaffected.Öğe The role of zinc in the endocrine system(UNIV KARACHI, 2019) Baltaci, Abdulkerim Kasim.; Mogulkoc, Rasim.; Baltaci, Saltuk Bugra.Zinc is essential in the regulation of a variety of physiological and biochemical events in the organism. It plays a critical role in maintaining the cell membrane integrity, protein-carbohydrate-lipid metabolism, immune system, wound injury and in the regulation of a number of other biological processes associated with normal growth and development. Physiological and biochemical levels of many hormones are affected by zinc metabolism. Therefore, growth impairment, hypogonadism, and some endocrine diseases are associated with the deficiency of zinc. These effects of zinc are considered versatile. Zinc increases the synthesis of the growth hormone and its number of receptors; thus, it is an important mediator in the binding of this hormone to its receptor. Found in a large quantity in the pancreas tissue, zinc has a part in the regulation of the effect of insulin. Zinc is involved to much more thyroid hormone metabolism such as hormone synthesis, receptor activity, conversion of T4 to T3, and production of carrier proteins. The low levels of zinc and high levels of leptin in obese individuals point to a critical relationship between zinc and leptin. Zinc is related to enzyme activity to melatonin synthesis. Melatonin has regulatory activity for zinc absorption from gastrointestinal system. Zinc particularly affects the conversion of testosterone to dihydrotestosterone, as 5 alpha-reductase that is involved in this conversion is a zinc-dependent enzyme. In consideration of these relations, zinc is accepted to play critical roles in the endocrine system. The aim of the current review is to draw attention to the effects of zinc on the endocrine system.
