Effect of 3 '-4 '-dihydroxyflavonol on lipid per oxidation in experimental renal ischemia-reperfusion in rats
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
UNIV KARACHI
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study aimed to examine the affects of 3'-4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental renal ischemia-reperfusion. The research was conducted on Wistar-albino type male rat. The experimental groups were formed as 1.Control; 2.Sham; 3.Ischemia; 4.Ischemia+reperfusion; 5.DiOHF+Ischemia; 6.Ischemia+ DiOHF + reperfusion. The highest tissue glutathione levels were found in groups 5 and 6. Groups 1 and 2, which were control and sham groups respectively, had the lowest tissue GSH values. Ischemia group was found to have the highest tissue malondialdehyde (MDA) level. Tissue MDA levels in group 4 were lower than those in group 3, however, higher than the levels in all other groups. Erythrocyte GSH levels in groups 5 and 6 were higher than the levels in all other groups. Group 4 has highest plasma MDA values. Plasma MDA levels in group 3 were lower than the levels in Group 4, but higher than those in other groups. The results of the study indicate that intraperitoneal DiOHF administration inhibits lipid per oxidation that intensifies in the case of renal ischemia-reperfusion injury in rats.
Açıklama
Anahtar Kelimeler
Renal ischemia-reperfusion, 3 '-4 '-Dihydroxyflavonol, lipid per oxidation, rat
Kaynak
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
32
Sayı
6
Künye
Koç, A., Ergene, N., Baltaci, A. K., Mogulkoc, R. (2019). Effect of 3’-4’-dihydroxyflavonol on Lipid Per Oxidation in Experimental Renal Ischemia-Reperfusion in Rats. Pakistan Journal of Pharmaceutical Sciences, 32(6), 2579-2584.
