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    Comparison of culture, Real- time-PCR, ELISA, and histopathological examination methods for identification of Helicobacter pylori
    (2018) Maçin, Salih; Alp, Alpaslan; Şener, Burçin; Sökmensüer, Cenk; Orhan, Diclehan; Özen, Hasan; Kav, Taylan
    Introduction: There are several methods used for the diagnosis of Helicobacterpylori infections, and there is an increasing demand for theuse of non-invasive, more rapid tests. The aim of the present study wasto compare different diagnostic methods.Methods: A total of 87 patients who had undergone esophagogastroduodenoscopywere included in the study. Biopsy samples obtainedfrom these patients were used for culture, real-time polymerase chainreaction (RT-PCR), and histopathological examination. Stool sampleswere also collected from these patients and were tested using the Helicobacterpylori stool antigen (HpSA) kit. Histopathological examinationwas accepted as the gold standard test.Results: H. pylori was identified by histological examination in 77/87(87.5%) patients, whereas it was negative in 10/87 (12.5%) patients. Furthermore,positive results were obtained in 55 (63.2%), 71 (81.6%), and 77(87.5%) patients using the culture method, HpSA analysis, and RT-PCR method,respectively. The sensitivity and specificity of culture, HpSA, and PCRtests were determined as 71.4% and 100%, 87% and 60%, and 97.4% and80%, respectively. Antibiotic susceptibility tests were performed on 48 outof the 55 culture positive samples. Resistance to clarithromycin was foundin 28 (58.3%), metronidazole in 14 (29.2%), and levofloxacin in 4 (8.3%) ofthe isolates. Resistance to amoxicillin and tetracycline was not observed.Conclusion: There are currently several invasive and non-invasive diagnostictests for the detection of H. pylori infections. Each test has someadvantages and disadvantages. The diagnostic method of choice shouldbe easy and applicable to all age groups.
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    Comparison of culture, Real-time-PCR, ELISA, and histopathological examination methods for identification of Helicobacter pylori
    (AVES, 2018) Macin, Salih; Alp, Alpaslan; Sener, Burcin; Sokmensuer, Cenk; Orhan, Diclehan; Ozen, Hasan; Kav, Taylan
    Introduction: There are several methods used for the diagnosis of Helicobacter pylori infections, and there is an increasing demand for the use of non-invasive, more rapid tests. The aim of the present study was to compare different diagnostic methods. Methods: A total of 87 patients who had undergone esophagogastro-duodenoscopy were included in the study. Biopsy samples obtained from these patients were used for culture, real-time polymerase chain reaction (RT-PCR), and histopathological examination. Stool samples were also collected from these patients and were tested using the Helicobacter pylori stool antigen (HpSA) kit. Histopathological examination was accepted as the gold standard test. Results: H. pylori was identified by histological examination in 77/87 (87.5%) patients, whereas it was negative in 10/87 (12.5%) patients. Furthermore, positive results were obtained in 55 (63.2%), 71 (81.6%), and 77 (87.5%) patients using the culture method, HpSA analysis, and RT-PCR method, respectively. The sensitivity and specificity of culture, HpSA, and PCR tests were determined as 71.4% and 100%, 87% and 60%, and 97.4% and 80%, respectively. Antibiotic susceptibility tests were performed on 48 out of the 55 culture positive samples. Resistance to clarithromycin was found in 28 (58.3%), metronidazole in 14 (29.2%), and levofloxacin in 4 (8.3%) of the isolates. Resistance to amoxicillin and tetracycline was not observed. Conclusion: There are currently several invasive and non-invasive diagnostic tests for the detection of H. pylori infections. Each test has some advantages and disadvantages. The diagnostic method of choice should be easy and applicable to all age groups.
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    Early onset of IgA nephropathy presenting with nephrotic syndrome
    (2008) Peru, Harun; Elmacı, Ahmet Midhat; Akın, Fatih; Orhan, Diclehan; Özel, Ahmet
    5 yasında erkek hasta hastanemize vucudunda sislik nedeniyle basvurdu. İdrar analizinde mikroskopik hematüri ve nefrotik düzeyde proteinüri saptandı. Kan basıncı normal sınırlardaydı. Kompleman 3 ve 4 düzeyleri normal, ANA negatifti. Hastaya 4 hafta süreyle prednizolon tedavisiverilmesine rağmen proteinürisi sebat ettiği için perkütan böbrek biyopsisi yapıldı. Biyopsi IgA nefropatisi ile uyumluydu. Tedaviye siklofosfamid eklendi. Proteinuri 12 haftalık siklofosfamid tedavisinden sonra düzeldi. Bu IgA nefropati olgusu erken yasta nefrotik sendrom kliniği ile ortaya çıkması sebebiyle rapor edilmistir.
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    Early onset of IgA nephropathy presenting with nephrotic syndrome
    (2008) Peru, Harun; Elmacı, Ahmet Midyat; Akın, Fatih; Orhan, Diclehan; Özel, Ahmet
    A 5-year-old boy was admitted to our hospital with the complaint of swelling of his whole body. Urine analysis revealed nephrotic range proteinuria and microscopic hematuria. He was normotensive. Complement C3 and C4 levels were normal. Antinuclear antibodies (ANA) were negative. A percutaneous renal biopsy was performed because of the persistent proteinuria despite a full course of 4 weeks of steroid treatment. The renal biopsy was consistent with IgA nephropathy. Then cyclophosphamide was added to the treatment. Proteinuria disappeared after 12 weeks of cyclophosphamide treatment. This case of IgA nephropathy is reported because of the early age of onset and because of presenting with nephrotic syndrome.
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    New Treatment Option for Adult-Onset Limbal Xanthogranuloma
    (LIPPINCOTT WILLIAMS & WILKINS, 2010) Mocan, Mehmet C.; Bozkurt, Banu; Orhan, Diclehan; Kuzey, Gamze; İrkeç, Murat
    [Abstract not Available]
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    An unusual association between familial Mediterranean fever and IgM nephropathy
    (KARGER, 2008) Peru, Harun; Elmaci, Ahmet Midhat; Akin, Fatih; Akcoren, Zuhal; Orhan, Diclehan
    Objective: To report a case with the diagnosis of IgM nephropathy and familial Mediterranean fever (FMF). Clinical Presentation and Intervention: A 9-year-old boy was admitted to our hospital with recurrent abdominal pain since the age of 4 years. Laboratory investigations revealed a sedimentation rate of 88 mm/h, C-reactive protein: 83.2 mg/l (0-10 mg/l), white blood cell count: 12,700/mm(3), fibrinogen: 622 mg/dl (200-400 mg/dl) and serum amyloid A: 186 mg/l (0-5.8 mg/l). Urinalysis revealed +2 proteinuria. A 24-hour urinary protein excretion was 12 mg/m(2)/h. M694V homozygous mutation was identified in exon 10. Percutaneous renal biopsy showed mesangial cell proliferation and increased mesangial matrix in the glomeruli, without amyloid accumulation. Immunofluorescence study showed IgM (+1) and C1q (+1) deposits. Treatment with 1 mg/day colchicine was started. Six weeks later, proteinuria had disappeared and the patient was asymptomatic. Conclusion: This case illustrates the unusual association of FMF with non-amyloid glomerulopathy. Glomerular diseases such as IgM nephropathy may be seen as a manifestation of FMF. Copyright (C) 2008 S. Karger AG, Basel.