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Öğe Blind Ending Uriner: A Rarely Diagnosed Ureteral Duplication Anomaly in Childhood(2010) Balasar, Mehmet; Pişkin, Mehmet Mesut; Çiçekçi, Faruk; Gürbüz, RecaiBlind ending ureıer is a rare congenital malformation of the urinary system and is classified as a ureteral duplication anomaly. Mast cases are not diagnosed until they become symptomatic. Although it is a congenital malformation, patients are usually diagnosed in the 3rd and 4th decades and presentation in childhood is very rare. Mostly they manifest with loin pain, urinary tract infection, or stone disease. Intravenous pyetogram, retrograde pyelogram, and computerized tomography can be used for diagnosis. Voiding cystourethrography must be performed to exclude associated vesicoureteral reflux. Herein, we report an 11-year-old child who hud a blind ending duplicated ureter associated with vesicoureteral reflux causing renal atrophy.Öğe Combination Antioxidant Effect of Alpha-tocoferol and Erdosteine in Ischemia-Reperfusion Injury in Rat Model(Springer, 2010) Yurdakul, Talat; Kulaksızoğlu, Haluk; Pişkin, Mehmet Mesut; Avunduk, Mustafa Cihat; Ertemli, Esra; Gökçe, Gürhan; Barışkaner, Hulagü; Büyükbaş, Sadık; Kocabaş, Volkan[Abstract not Available]Öğe Combination Antioxidant Effect of Alpha-Tocoferol and Erdosteine in Ischemia-Reperfusion Injury in Rat Model(Springer, 2010) Yurdakul, Talat; Kulaksızoğlu, Haluk; Pişkin, Mehmet Mesut; Avunduk, Mustafa Cihat; Ertemli, Esra; Barışkaner, Hulagü; Büyükbaş, Sadık; Kocabaş, VolkanIntroduction Renal ischemia/reperfusion (I/R) which is an important cause of renal dysfunction is inevitable in renal transplantation, surgical revascularization of the renal artery, partial nephrectomy and treatment of suprarenal aortic aneurysms. Aim The purpose of this study was to investigate the efficacy of alpha-tocopherol and erdosteine combination in the reduction in injury induced by ROS in a rat model of renal ischemia-reperfusion. Materials and methods Thirty-six-male Wistar albino rats weighing 200-250 g were utilized for this study. Rats were divided into six groups, and each group was consistent of six rats: (1) sham-operated (control), (2) ischemia group (3) I/R group, (4) I/R/alpha-tocoferol group (5) I/erdosteine group (6). I/R/alpha-tocoferol and erdosteine group. Biochemically tissue MDA, XO and SOD activities, light and electron microscopic findings were evaluated. Results The erdosteine and alpha-tocoferol significantly reversed the effect of protein oxidation and lipid peroxidation induced by I/R shown by the decreased levels of MDA and XO activities. Both MDA and XO levels were found to be lower in group 6 compared to single agent treatment groups, and this was significantly different. All treatment groups showed increased SOD activity, which accounts for their oxidative properties. The mean Paller score of the combination treatment group (group 6) was lower than all groups except the sham group (3.67 +/- 1.2), and this finding was statistically significant (0.05). Our results showed that the antioxidant pretreatment with alpha-tocopherol and erdosteine combination reduced lipid peroxidation of renal cellular membranes in a model of normothermic renal ischemia-reperfusion in rats. Combination of erdosteine and alpha-tocopherol has a synergistic effect of protection against oxidative processes. Long-term use of alpha-tocopherol seems to have a greater effect on the prevention of IR injury. However, further investigations are needed for the clinical applications of our findings.Öğe Endoscopic Treatment of Fibroepithelial Polyp Coexisting Ureter Stone(2007) Pişkin, Mehmet Mesut; Kılınç, Mehmet; Toy, HaticeAlthough ureteral tumors are rare both in children and adults, fi broepithelial polyp is the most common benign tumor of the ureter. Fibroepithelial polyps are traditionally treated with open surgery. By the introduction of ureteroscopy, the treatment of these lesion is achived by endoscopic manner. We report a case of fi broepithelial polyp associated with ureteral stone treated endoscopically.Öğe Malignant Melanoma of the Glans Penis and Male Urethra(2006) Arslan, Mehmet; Gökçe, Gürhan; Pişkin, Mehmet Mesut; Kılınç, Mehmet; Güngör, Salim; Güven, SelçukMalignant melanoma (MM) of the penis is rare and accounts for a small percentage of malignant melanomas and of malignant penile lesions. The problem of the therapeutic approach is still unsolved. In general prognosis is poor and most patients die within a few years becouse of the distant metastasis.Öğe Pelvic Hydatic Disease Causing Renal Failure(2006) Yurdakul, Talat; Pişkin, Mehmet MesutPelvik hidatik kistin akut böbrek yetmezliği oluşturması son derece nadir bir durumdur. Pelvik yerleşimli hidatik kiste bağlı gelişen obstrüktif üropatinin sebep olduğu akut böbrek yetmezliğine giren 24 yaşındaki bir olguyu sunuyoruz.Öğe Primary Hydatid Cyst in Adrenal Gland: A Case Report(2005) Gürbüz, Recai; Güven, Selçuk; Kılınç, Mehmet; Abasıyanık, Fatma; Gökçe, Gürhan; Pişkin, Mehmet MesutThe hydatid cyst of the adrenal gland is extremely rare pathology of the adrenal gland; here we report an adrenal hydatid cyst that presented as a solitary renal tumor. © Springer 2005.Öğe Üriner Sistem Kalsiyum Taş Hastalığına Bağlı Kemik Kütlesi Değişiklikleri(2008) Pişkin, Mehmet Mesut; Karalezli, Giray; Kılınç, MehmetAmaç: Üriner sistem taş hastalığı ülkemizde sık görülen bir patolojidir. Kalsiyum taşları bu hastalık grubunun en büyük kısmını oluşturur. Hiperkalsiüri, taş hastalarında en sık görülen metabolik bozukluktur ve bu hastalarda kalsiyum metabolizması bozularak kemik kütlesini etkileyebilmektedir. Bu çalışmada kalsiyum taş hastalığı bulunan hastalardaki kemikler kütlesindeki değişikliklerin araştırılması amaçlandı. Yöntem: Çalışmaya kalsiyum taş hastalığı tanısı ile takip edilen yaşları 20-50 arasında değişen (ortalama yaş 39.8) 41 erkek olgu alındı. Taş hastalığı hikayesi bulunmayan 20-50 yaşları arasında değişen (ortalama yaş 39.9) 40 erkek olgu ise kontrol grubu olarak alındı. Her iki grubun kemik kütle ölçümleri femur boynu ve lumbal vertebra düzeyinde dual-enerji-x-ray absorpsiyometri yöntemi ile yapıldı. Olgulara diyet kısıtlanması yapılmadan 24 saatlik idrar metabolik değerlendirmesi, kan biyokimyası testleri yapıldı. Bulgular: Çalışma grubu ile kontrol grubunun yaş dağılımları ve vücut kütle indeksleri arasında anlamlı fark saptanmadı (P0.097). Taş hastalığı bulunan olgulardan 20’si (% 48) hiperkalsiürik idi. Kemik mineral dansiteleri çalışma grubundaki 17 olguda (% 41), kontrol grubunda ise yalnızca bir olguda (% 2.5) düşük idi, gruplar arasında anlamlı fark vardı (P0.05). Osteoporoz ve osteopeni oranları çalışma grubunda kontrol grubuna göre fazla bulundu (P0.001, P0.001). Osteoporoz ile rekürrens arasında anlamlı ilişki bulundu (r0717, P0.01). Sonuç: Taş hastalığı osteoporoz için bir risk faktörüdür. Özellikle rekürren olgularda kemik kütlesi değerlendirilmeli, koruyucu önlemler alınmalı ve hastalar bilgilendirilmelidir.
