Yazar "Sisto, Francesca" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    Chromatographic analyses, in vitro biological activities, and cytotoxicity of cannabis sativa l. essential oil: a multidisciplinary study
    (MDPI, 2018) Zengin, Gökhan; Menghini, Luigi; Sotto, Antonella Di; Mancinelli, Romina; Sisto, Francesca; Carradori, Simone; Cesa, Stefania; Fraschetti, Caterina; Filippi, Antonello; Angiolella, Letizia; Locatelli, Marcello; Mannina, Luisa; Ingallina, Cinzia; Puca, Valentina; D’Antonio, Marianna; Grande, Rossella
    Due to renewed interest in the cultivation and production of Italian Cannabis sativa L., we proposed a multi-methodological approach to explore chemically and biologically both the essential oil and the aromatic water of this plant. We reported the chemical composition in terms of cannabinoid content, volatile component, phenolic and flavonoid pattern, and color characteristics. Then, we demonstrated the ethnopharmacological relevance of this plant cultivated in Italy as a source of antioxidant compounds toward a large panel of enzymes (pancreatic lipase, -amylase, -glucosidase, and cholinesterases) and selected clinically relevant, multidrug-sensible, and multidrug-resistant microbial strains (Staphylococcus aureus, Helicobacter pylori, Candida, and Malassezia spp.), evaluating the cytotoxic effects against normal and malignant cell lines. Preliminary in vivo cytotoxicity was also performed on Galleria mellonella larvae. The results corroborate the use of this natural product as a rich source of important biologically active molecules with particular emphasis on the role exerted by naringenin, one of the most important secondary metabolites.
  • Küçük Resim
    Öğe
    Phytochemical Analyses and Pharmacological Screening of Neem Oil
    (ELSEVIER, 2019) Cesa, Stefania; Sisto, Francesca; Zengin, Gökhan; Scaccabarozzi, Diletta; Kokolakis, Antonios K.; Scaltrito, Maria Maddalena; Grande, Rossella; Locatelli, Marcello; Cacciagrano, Francesco; Angiolella, Letizia; Campestre, Cristina; Granese, Arianna; Chimenti, Paola; Basilico, Nicoletta
    An Italian certified Neemseed oil was characterized through the color analysis, the HPLC phenolic fingerprint and the preliminary evaluation of the cytotoxicity profile against the human macrophage (THP-1) cell line. Moreover, a wide screening of its enzyme inhibitory profile, antimicrobial activity towards Helicobacter pylori, several Candida spp. and Malassezia furfur strains and antiprotozoal activity against Plasmodium falciparum, Leishmania infantum and Leishmania tropica were performed. Neemseed oil demonstrated low toxicity and a great inhibitory efficacy against tyrosinase and lipase enzymes. Antimalarial and anti-leishmanial activities were also demonstrated, but weak or no activity was evidenced against Helicobacter pylori, Candida and Malassezia strains. Overall, these findings encourage the potential use of this natural product in some disease treatments and justify its use in traditional medicine. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved.