Chromatographic analyses, in vitro biological activities, and cytotoxicity of cannabis sativa l. essential oil: a multidisciplinary study
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
MDPI
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Due to renewed interest in the cultivation and production of Italian Cannabis sativa L., we proposed a multi-methodological approach to explore chemically and biologically both the essential oil and the aromatic water of this plant. We reported the chemical composition in terms of cannabinoid content, volatile component, phenolic and flavonoid pattern, and color characteristics. Then, we demonstrated the ethnopharmacological relevance of this plant cultivated in Italy as a source of antioxidant compounds toward a large panel of enzymes (pancreatic lipase, -amylase, -glucosidase, and cholinesterases) and selected clinically relevant, multidrug-sensible, and multidrug-resistant microbial strains (Staphylococcus aureus, Helicobacter pylori, Candida, and Malassezia spp.), evaluating the cytotoxic effects against normal and malignant cell lines. Preliminary in vivo cytotoxicity was also performed on Galleria mellonella larvae. The results corroborate the use of this natural product as a rich source of important biologically active molecules with particular emphasis on the role exerted by naringenin, one of the most important secondary metabolites.
Açıklama
Anahtar Kelimeler
Cannabis sativa L, Chromatographic analysis, Essential oil, Antimicrobial activity, Cancer cell cytotoxicity, Naringenin, Biofilm, Antioxidant activity, Galleria mellonella
Kaynak
MOLECULES
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
23
Sayı
12
Künye
Zengin, G., Menghini, L., Sotto, A. D., Mancinelli, R., Sisto, F., Carradori, S., Cesa, S., Fraschetti, C., Filippi, A., Angiolella, L., Locatelli, M., Mannina, L., Ingallina, C., Puca, V., D’Antonio, M., Grande, R. (2018). Chromatographic Analyses, In Vitro Biological Activities, and Cytotoxicity of Cannabis sativa L. Essential Oil: A Multidisciplinary Study. Molecules, 23(12).
