Chromatographic analyses, in vitro biological activities, and cytotoxicity of cannabis sativa l. essential oil: a multidisciplinary study

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dc.authorid0000-0001-6548-7823
dc.authorid0000-0002-7346-7395
dc.authorid0000-0002-7467-1689
dc.authorid0000-0002-8698-9440
dc.authorid0000-0002-8649-0017
dc.authorid0000-0002-0473-5587
dc.authorid0000-0002-0840-825X
dc.contributor.authorZengin, Gökhan
dc.contributor.authorMenghini, Luigi
dc.contributor.authorSotto, Antonella Di
dc.contributor.authorMancinelli, Romina
dc.contributor.authorSisto, Francesca
dc.contributor.authorCarradori, Simone
dc.contributor.authorCesa, Stefania
dc.contributor.authorFraschetti, Caterina
dc.contributor.authorFilippi, Antonello
dc.contributor.authorAngiolella, Letizia
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorMannina, Luisa
dc.contributor.authorIngallina, Cinzia
dc.contributor.authorPuca, Valentina
dc.contributor.authorD’Antonio, Marianna
dc.contributor.authorGrande, Rossella
dc.date.accessioned2020-03-26T19:53:05Z
dc.date.available2020-03-26T19:53:05Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümü.en_US
dc.description.abstractDue to renewed interest in the cultivation and production of Italian Cannabis sativa L., we proposed a multi-methodological approach to explore chemically and biologically both the essential oil and the aromatic water of this plant. We reported the chemical composition in terms of cannabinoid content, volatile component, phenolic and flavonoid pattern, and color characteristics. Then, we demonstrated the ethnopharmacological relevance of this plant cultivated in Italy as a source of antioxidant compounds toward a large panel of enzymes (pancreatic lipase, -amylase, -glucosidase, and cholinesterases) and selected clinically relevant, multidrug-sensible, and multidrug-resistant microbial strains (Staphylococcus aureus, Helicobacter pylori, Candida, and Malassezia spp.), evaluating the cytotoxic effects against normal and malignant cell lines. Preliminary in vivo cytotoxicity was also performed on Galleria mellonella larvae. The results corroborate the use of this natural product as a rich source of important biologically active molecules with particular emphasis on the role exerted by naringenin, one of the most important secondary metabolites.en_US
dc.description.sponsorshipRegione Lazio [13/2008]; MIUR FFABR2017 grants; Abruzzo District project "Filiera Regionale delle Piante Officinali"; Enrico and Enrica Sovena Foundation; Regione Lazio (La Canapa industriale: sviluppo e valorizzazione di una nuova filiera agroalimentare ecosostenibile, Italy) [CUP: B86C1800073002, 85201715069]en_US
dc.description.sponsorshipThis work was supported by Regione Lazio (L.R. 13/2008-Progetti di Gruppi di Ricerca; La Canapa industriale: sviluppo e valorizzazione di una nuova filiera agroalimentare ecosostenibile, CUP: B86C1800073002, protocol number 85201715069, Italy) and by MIUR FFABR2017 grants held by Rossella Grande. The experimental work was supported by the Abruzzo District project "Filiera Regionale delle Piante Officinali". Antonella Di Sotto was supported by the "Enrico and Enrica Sovena Foundation".en_US
dc.identifier.citationZengin, G., Menghini, L., Sotto, A. D., Mancinelli, R., Sisto, F., Carradori, S., Cesa, S., Fraschetti, C., Filippi, A., Angiolella, L., Locatelli, M., Mannina, L., Ingallina, C., Puca, V., D’Antonio, M., Grande, R. (2018). Chromatographic Analyses, In Vitro Biological Activities, and Cytotoxicity of Cannabis sativa L. Essential Oil: A Multidisciplinary Study. Molecules, 23(12).
dc.identifier.doi10.3390/molecules23123266en_US
dc.identifier.issn1420-3049en_US
dc.identifier.issue12en_US
dc.identifier.pmid30544765en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.3390/molecules23123266
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36400
dc.identifier.volume23en_US
dc.identifier.wosWOS:000454523000216en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofMOLECULESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCannabis sativa Len_US
dc.subjectChromatographic analysisen_US
dc.subjectEssential oilen_US
dc.subjectAntimicrobial activityen_US
dc.subjectCancer cell cytotoxicityen_US
dc.subjectNaringeninen_US
dc.subjectBiofilmen_US
dc.subjectAntioxidant activityen_US
dc.subjectGalleria mellonellaen_US
dc.titleChromatographic analyses, in vitro biological activities, and cytotoxicity of cannabis sativa l. essential oil: a multidisciplinary studyen_US
dc.typeArticleen_US

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