Phytochemical Analyses and Pharmacological Screening of Neem Oil
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ELSEVIER
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
An Italian certified Neemseed oil was characterized through the color analysis, the HPLC phenolic fingerprint and the preliminary evaluation of the cytotoxicity profile against the human macrophage (THP-1) cell line. Moreover, a wide screening of its enzyme inhibitory profile, antimicrobial activity towards Helicobacter pylori, several Candida spp. and Malassezia furfur strains and antiprotozoal activity against Plasmodium falciparum, Leishmania infantum and Leishmania tropica were performed. Neemseed oil demonstrated low toxicity and a great inhibitory efficacy against tyrosinase and lipase enzymes. Antimalarial and anti-leishmanial activities were also demonstrated, but weak or no activity was evidenced against Helicobacter pylori, Candida and Malassezia strains. Overall, these findings encourage the potential use of this natural product in some disease treatments and justify its use in traditional medicine. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Color analysis, HPLC-PDA, H. pylori, Neem oil, Malaria, Leishmania, Enzyme inhibition, Enzim inhibisyonu, Neem yağı
Kaynak
South African Journal of Botany
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
120
Sayı
Künye
Cesa, S., Sisto, F., Zengin, G., Scaccabarozzi, D., Kokolakis, A. K., Scaltrito, M. M., Grande, R., Locatelli, M., Cacciagrona, F., Angiolella, L., Campestre, C., Granese, A., Chimenti, P., Basilico, N. (2019). Phytochemical analyses and Pharmacological Screening of Neem Oil. South African Journal of Botany, 120, 331-337. doi: https://dx.doi.org/10.1016/j.sajb.2018.10.019
