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Öğe Cancer and Thrombosis(2012) Dağlı, M.; Sivrikaya, A.Venous thrombosis development is the most important causes of morbidity and mortality in the cases with carcinoma. Besides prevention and treatment of the disease, studies clarifying pathophysiology are required in clinical studies. It is possible to research the initiating factors of forming thrombus in two groups; intravenous and extravenous. Intravenous factors: tissue factors, carcinoma procoagulant, TNF secreted from carcerous cells, IL1, plasminogen activator inhibitor, mucin, thrombomodulus, ADP, heparin sulphat, annexing II can be considered. Extravenous factors are the size of cancerous mass, histopathologic diagnoses, the pressure it causes, vascular wall damage, venous stasis, lengthened immobilization, chemotherapy and surgical interventions. By supporting these factors that contribute to forming thrombosis in the cancer patients with the literature data, treatment choices against the risk of thrombosis will be suggested with the help of guides. © IDOSI Publications, 2012.Öğe The Effect of Thyroxine Administration on Lipid Peroxidation in Different Tissues of Rats With Hypothyroidism(2005) Moğulkoç, R.; Baltacı, A. K.; Aydın, L.; Öztekin, E.; Sivrikaya, A.Thyroid dysfunctions bring about pathological changes in different organs of the body. Findings obtained from in vivo and in vitro studies point out that thyroid hormones have a strong impact on oxidative stress. The present study was conducted to demonstrate how high-dose thyroxin administration for one week affected oxidative damage formed in experimental hypothyroidism. The study was carried out with 30 Spraque-Dawley species male rats. The experimental animals were divided into 3 groups (Group 1, control; Group 2, hypothyroidism; Group 3, hypothyroidism + thyroxine administration). Malondialdehyde (MDA) and glutathione (GSH) levels were determined in cerebral, hepatic and cardiac tissues after the experimental period. MDA and GSH levels in cerebral, hepatic and cardiac tissues of hypothyroidism + thyroxine supplemented group were higher than those in the control and hypothyroidism groups (p<0.001). The same parameters were higher in the control group than those in the hypothyroidism group (p<0.001). The results of the present study show that hypothyroidism reduced the oxidative damage in cerebral, hepatic and cardiac tissues of rats. However, high-dose thyroxine administration in addition to induced hypothyroidism increased oxidative damage in the same tissues and that this damage could not be prevented despite the increase in the antioxidant system activity.Öğe Effects of Hyperthyroidism Induced by L-Thyroxin Administration on Lipid Peroxidation in Various Rat Tissues(Akademiai Kiado, 2006) Moğulkoç, R.; Baltacı, A. Kasım; Öztekin, Esma; Sivrikaya, A.; Aydın, LeylaThyroid dysfunctions are associated with many pathological signs in the body. One of these is lipid peroxidation that develops due to over- or under-secretion of thyroid hormones. The present study was conducted to determine lipid peroxidation that develops in different tissues including the brain, liver and heart of rats in experimental hyperthyroidism induced by L-thyroxin. The study was carried out on 30 male Sprague-Dawley rats. They were divided into three groups as control, sham hyperthyroidism and hyperthyroidism. Malondialdehyde (MDA) and glutathione (GSH) levels in rat tissues were determined at the end of a 3-weeks period of L-thyroxin administration. It was observed that MDA levels in the hyperthyroidism group were significantly higher in the cerebral cortex, liver and ventriculer tissue of heart (p < 0.001) than in the control and in sham hyperthyroidism groups. GSH levels were higher in the hyperthyroidism group than in control and sham hyperthyroidism groups in all tissues (p < 0.001). Results demonstrate that hyperthyroidism induced by L-thyroxin activates both oxidant and antioxidant systems in cerebral, hepatic and cardiac tissues. However, the increase in antioxidant activity cannot adequately prevent oxidative damage.Öğe Mean platelet volume values in patients with multiple myeloma(WILEY-BLACKWELL, 2016) Abuşoğlu, Sedat; Bingöl, Y.; Ünlü, Ali; Sivrikaya, A.[Abstract not Available]Öğe Platelet/lymphocyte ratio in patients with Behcet's disease(WILEY-BLACKWELL, 2016) Ünlü, Ali; Abuşoğlu, Sedat; Sivrikaya, A.; Bingöl, Y.[Abstract not Available]Öğe The Role of Zinc Supplementation in the Inhibition of Tissue Damage Caused by Exposure to Electromagnetic Field in Rat Lung and Liver Tissues(COMENIUS UNIV, 2012) Baltacı, A. K.; Moğulkoç, R.; Salbacak, A.; Çelik, I; Sivrikaya, A.Background: The objective of the present study was to examine the effects of zinc supplementation on the oxidant damage in lung and liver tissues in rats exposed to a 50-Hz frequency magnetic field for 5 minutes every other day over a period of 6 months. Methods: The study included 24 adult male Sprague-Dawley rats, which were divided into the three groups in equal numbers: Group 1, the control group (G1); Group 2, the group exposed to an electromagnetic field (G2); and Group 3, the group, which was exposed to an EMF and supplemented with zinc (G3). At the end of the 6-month procedures, the animals were decapitated to collect lung and liver tissue samples, in which MDA was analyzed using the "TBARS method (nmol/g/protein)", GSH by the "biuret method (mg/g/protein)" and zinc levels by atomic emission (mu g/dl). Results: MDA levels in lung and liver tissues in G2 were higher than those in G1 and G3, and the levels in G3 were higher than those in G1 (p<0.01). As for GSH levels, G3 had GSH levels higher than G1 and G2, and G2 had GSH levels higher than G1 (p<0.01). Zinc values in the liver and lung tissues were the highest in the Group 3 and the lowest in the Group 2 (p<0.01). Conclusion: Results of the study indicated that exposure to an electromagnetic field caused cellular damage in lung and liver tissues and zinc supplementation inhibited the inflicted cellular damage. Another important result of this study that needs emphasis was that exposure to an electromagnetic field led to a significant decrease in zinc levels in lung and liver tissues (Tab. 3, Ref. 23).Öğe Serum vitamin B12 levels in patients with Behcet's disease(WILEY-BLACKWELL, 2016) Hataysal, Esra Paydaş; Ünlü, Ali; Sivrikaya, A.; Abuşoğlu, Sedat[Abstract not Available]Öğe Serum vitamin D levels in patients with chronic obstructive pulmonary disease(WILEY, 2017) Ünlü, Ali; Abuşoğlu, Sedat; Sivrikaya, A.; Eryavuz, Duygu[Abstract not Available]Öğe Serum vitamin D levels in patients with hypothyroidism(WILEY-BLACKWELL, 2016) Sivrikaya, A.; Abuşoğlu, Sedat; Ünlü, Ali[Abstract not Available]Öğe Vitamin D levels in patients with rheumatoid arthritis(WILEY-BLACKWELL, 2016) Ünlü, Ali; Eryavuz, D.; Sivrikaya, A.; Abuşoğlu, Sedat[Abstract not Available]
