The Effect of Thyroxine Administration on Lipid Peroxidation in Different Tissues of Rats With Hypothyroidism
Yükleniyor...
Dosyalar
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Thyroid dysfunctions bring about pathological changes in different organs of the body. Findings obtained from in vivo and in vitro studies point out that thyroid hormones have a strong impact on oxidative stress. The present study was conducted to demonstrate how high-dose thyroxin administration for one week affected oxidative damage formed in experimental hypothyroidism. The study was carried out with 30 Spraque-Dawley species male rats. The experimental animals were divided into 3 groups (Group 1, control; Group 2, hypothyroidism; Group 3, hypothyroidism + thyroxine administration). Malondialdehyde (MDA) and glutathione (GSH) levels were determined in cerebral, hepatic and cardiac tissues after the experimental period. MDA and GSH levels in cerebral, hepatic and cardiac tissues of hypothyroidism + thyroxine supplemented group were higher than those in the control and hypothyroidism groups (p<0.001). The same parameters were higher in the control group than those in the hypothyroidism group (p<0.001). The results of the present study show that hypothyroidism reduced the oxidative damage in cerebral, hepatic and cardiac tissues of rats. However, high-dose thyroxine administration in addition to induced hypothyroidism increased oxidative damage in the same tissues and that this damage could not be prevented despite the increase in the antioxidant system activity.
Açıklama
Anahtar Kelimeler
Cardiac tissue, Cerebral tissue, Glutathione (GSH), Hepatic tissue, Hypothyroidism, Lipid peroxidation, Malondialdehyde (MDA), Oxidative damage, Rat, Thyroid dysfunction, Thyroid hormones, Thyroxine administration
Kaynak
Acta Physiologica Hungarica
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
92
Sayı
1
Künye
Moğulkoç, R., Baltacı, A. K., Aydın, L., Öztekin, E., Sivrikaya, A., (2005). The Effect of Thyroxine Administration on Lipid Peroxidation in Different Tissues of Rats With Hypothyroidism. Acta Physiologica Hungarica, 92(1), 39-46.
