The Effect of Thyroxine Administration on Lipid Peroxidation in Different Tissues of Rats With Hypothyroidism

Basit Öğe Kaydı
dc.contributor.authorMoğulkoç, R.
dc.contributor.authorBaltacı, A. K.
dc.contributor.authorAydın, L.
dc.contributor.authorÖztekin, E.
dc.contributor.authorSivrikaya, A.
dc.date.accessioned2020-03-26T16:58:59Z
dc.date.available2020-03-26T16:58:59Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThyroid dysfunctions bring about pathological changes in different organs of the body. Findings obtained from in vivo and in vitro studies point out that thyroid hormones have a strong impact on oxidative stress. The present study was conducted to demonstrate how high-dose thyroxin administration for one week affected oxidative damage formed in experimental hypothyroidism. The study was carried out with 30 Spraque-Dawley species male rats. The experimental animals were divided into 3 groups (Group 1, control; Group 2, hypothyroidism; Group 3, hypothyroidism + thyroxine administration). Malondialdehyde (MDA) and glutathione (GSH) levels were determined in cerebral, hepatic and cardiac tissues after the experimental period. MDA and GSH levels in cerebral, hepatic and cardiac tissues of hypothyroidism + thyroxine supplemented group were higher than those in the control and hypothyroidism groups (p<0.001). The same parameters were higher in the control group than those in the hypothyroidism group (p<0.001). The results of the present study show that hypothyroidism reduced the oxidative damage in cerebral, hepatic and cardiac tissues of rats. However, high-dose thyroxine administration in addition to induced hypothyroidism increased oxidative damage in the same tissues and that this damage could not be prevented despite the increase in the antioxidant system activity.en_US
dc.identifier.citationMoğulkoç, R., Baltacı, A. K., Aydın, L., Öztekin, E., Sivrikaya, A., (2005). The Effect of Thyroxine Administration on Lipid Peroxidation in Different Tissues of Rats With Hypothyroidism. Acta Physiologica Hungarica, 92(1), 39-46.
dc.identifier.doi10.1556/APhysiol.92.2005.1.6en_US
dc.identifier.endpage46en_US
dc.identifier.issn0231-424Xen_US
dc.identifier.issue1en_US
dc.identifier.pmid16003944en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://dx.doi.org/10.1556/APhysiol.92.2005.1.6
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20047
dc.identifier.volume92en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofActa Physiologica Hungaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCardiac tissueen_US
dc.subjectCerebral tissueen_US
dc.subjectGlutathione (GSH)en_US
dc.subjectHepatic tissueen_US
dc.subjectHypothyroidismen_US
dc.subjectLipid peroxidationen_US
dc.subjectMalondialdehyde (MDA)en_US
dc.subjectOxidative damageen_US
dc.subjectRaten_US
dc.subjectThyroid dysfunctionen_US
dc.subjectThyroid hormonesen_US
dc.subjectThyroxine administrationen_US
dc.titleThe Effect of Thyroxine Administration on Lipid Peroxidation in Different Tissues of Rats With Hypothyroidismen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
20047.pdf
Boyut:
574.88 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu