Effects of Hyperthyroidism Induced by L-Thyroxin Administration on Lipid Peroxidation in Various Rat Tissues
Yükleniyor...
Dosyalar
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Akademiai Kiado
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Thyroid dysfunctions are associated with many pathological signs in the body. One of these is lipid peroxidation that develops due to over- or under-secretion of thyroid hormones. The present study was conducted to determine lipid peroxidation that develops in different tissues including the brain, liver and heart of rats in experimental hyperthyroidism induced by L-thyroxin. The study was carried out on 30 male Sprague-Dawley rats. They were divided into three groups as control, sham hyperthyroidism and hyperthyroidism. Malondialdehyde (MDA) and glutathione (GSH) levels in rat tissues were determined at the end of a 3-weeks period of L-thyroxin administration. It was observed that MDA levels in the hyperthyroidism group were significantly higher in the cerebral cortex, liver and ventriculer tissue of heart (p < 0.001) than in the control and in sham hyperthyroidism groups. GSH levels were higher in the hyperthyroidism group than in control and sham hyperthyroidism groups in all tissues (p < 0.001). Results demonstrate that hyperthyroidism induced by L-thyroxin activates both oxidant and antioxidant systems in cerebral, hepatic and cardiac tissues. However, the increase in antioxidant activity cannot adequately prevent oxidative damage.
Açıklama
Anahtar Kelimeler
hyperthyroidism, MDA, GSH, brain, liver, heart
Kaynak
Acta Biologica Hungarica
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
57
Sayı
2
Künye
Moğulkoç, R., Baltacı, A. K., Öztekin, E., Sivrikaya, A., Aydın, L., (2006). Effects of Hyperthyroidism Induced by L-Thyroxin Administration on Lipid Peroxidation in Various Rat Tissues. Acta Biologica Hungarica, 57(2), 157-163. Doi: 10.1556/ABiol.57.2006.2.3
