Effects of Hyperthyroidism Induced by L-Thyroxin Administration on Lipid Peroxidation in Various Rat Tissues

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dc.contributor.authorMoğulkoç, R.
dc.contributor.authorBaltacı, A. Kasım
dc.contributor.authorÖztekin, Esma
dc.contributor.authorSivrikaya, A.
dc.contributor.authorAydın, Leyla
dc.date.accessioned2020-03-26T17:03:27Z
dc.date.available2020-03-26T17:03:27Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThyroid dysfunctions are associated with many pathological signs in the body. One of these is lipid peroxidation that develops due to over- or under-secretion of thyroid hormones. The present study was conducted to determine lipid peroxidation that develops in different tissues including the brain, liver and heart of rats in experimental hyperthyroidism induced by L-thyroxin. The study was carried out on 30 male Sprague-Dawley rats. They were divided into three groups as control, sham hyperthyroidism and hyperthyroidism. Malondialdehyde (MDA) and glutathione (GSH) levels in rat tissues were determined at the end of a 3-weeks period of L-thyroxin administration. It was observed that MDA levels in the hyperthyroidism group were significantly higher in the cerebral cortex, liver and ventriculer tissue of heart (p < 0.001) than in the control and in sham hyperthyroidism groups. GSH levels were higher in the hyperthyroidism group than in control and sham hyperthyroidism groups in all tissues (p < 0.001). Results demonstrate that hyperthyroidism induced by L-thyroxin activates both oxidant and antioxidant systems in cerebral, hepatic and cardiac tissues. However, the increase in antioxidant activity cannot adequately prevent oxidative damage.en_US
dc.identifier.citationMoğulkoç, R., Baltacı, A. K., Öztekin, E., Sivrikaya, A., Aydın, L., (2006). Effects of Hyperthyroidism Induced by L-Thyroxin Administration on Lipid Peroxidation in Various Rat Tissues. Acta Biologica Hungarica, 57(2), 157-163. Doi: 10.1556/ABiol.57.2006.2.3
dc.identifier.doi10.1556/ABiol.57.2006.2.3en_US
dc.identifier.endpage163en_US
dc.identifier.issn0236-5383en_US
dc.identifier.issue2en_US
dc.identifier.pmid16841467en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://dx.doi.org/10.1556/ABiol.57.2006.2.3
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20463
dc.identifier.volume57en_US
dc.identifier.wosWOS:000238690500003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMoğulkoç, R.
dc.institutionauthorBaltacı, A. Kasım
dc.institutionauthorÖztekin, Esma
dc.institutionauthorSivrikaya, A.
dc.institutionauthorAydın, Leyla
dc.language.isoenen_US
dc.publisherAkademiai Kiadoen_US
dc.relation.ispartofActa Biologica Hungaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthyperthyroidismen_US
dc.subjectMDAen_US
dc.subjectGSHen_US
dc.subjectbrainen_US
dc.subjectliveren_US
dc.subjecthearten_US
dc.titleEffects of Hyperthyroidism Induced by L-Thyroxin Administration on Lipid Peroxidation in Various Rat Tissuesen_US
dc.typeArticleen_US

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