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Öğe The effect of 3?,4?-dihydroxyflavonol on plasma oxidant and antioxidant systems in testis ischemia-reperfusion injury in rats(AMG Transcend Association, 2018) Duman A.; Mogulkoc R.; Baltaci A.K.; Sivrikaya A.The purpose of the present study was to determine the effect of 3’,4’-dihydroxyflavonol (DiOHF) on plasma lipid peroxidation in experimental testicular torsion-detorsion.The study involved 60 Wistar-albino type male rats weighing 250-260 gr. The experiment groups were formed as follows: 1. Control; 2. Sham-control; 3.720o-4 hours torsion; 4. 720o-4 hours torsion + 4 hours detorsion; 5. 720o-4 hours torsion + DiOHF; 6. 720o-4 hours torsion + DiOHF + 4 hours detorsion; 7. 720o-4 hours torsion + 24 hours detorsion; 8. 720o-4 hours torsion + DiOHF + 24 hours detorsion. The animals in the experimental groups were anesthetized after the procedures and their blood samples were taken to determine the levels of plasma glutathione peroxidase (GPx), nitric oxide (NO), malondialdehyde (MDA), and erythrocyte glutathione (GSH). Among the study groups, group 5 was found to have the highest plasma glutathione peroxidase values (p<0.001). Groups 3 and 4, which were torsion and detorsion groups, had the lowest plasma GPx values (p<0.001).Plasma NO values were found be higher in groups 3 and 4 than all other groups (p<0.001).Groups 3, 4, and 7 had the highest plasma MDA levels (p<0.001).Erythrocyte GSH levels in groups 5 and 7 were significantly higher than the levels in other groups (p<0.001).The results of the study indicate that lipid peroxidation that increases in plasma during testis ischemia-reperfusion injury in rats is prevented by intra-peritoneal DiOHF administration. © 2018 by the authors.Öğe Plasma essential fatty acid levels and ?-6/?-3 ratio in healthy people living in our region [Bölgemizde yaşayan sa?likli kişilerde plazma esansiyel ya? asidi düzeyleri ve ?-6/?-3 ya? asitleri orani](2011) Yerlikaya F.H.; Mehmeto?lu I.; Sivrikaya A.Objective: Essential fatty acids are essential for survival of humans and other mammals, and they can not be synthesized in the body: hence, they have to be obtained by the diet. There are two types of essential fatty acids in the body, the omega-6 (?6) series derived from linoleic acid and the omega-3 (?3) series derived from linolenic acid. In this study we aimed to examine plasma essential fatty acid levels, omega-6/omega-3 (?6/?3) ratio and these fatty acids in the relationship between body mass index (BMI) and waist circumference in healty subjects living in our region. Material and Methods: This study was performed on 91 (31 male 60 female) healthy people living in the city of Konya aged 18-70 years. There was no complaints and symptoms of the healthy people. Fatty acid levels were measured by Gas chromatography-mass spectrometry technique. Results: There were no significant differences between plasma essential fatty acid levels of the male and female healthy subjects. There were significantly positive correlations between plasma ?-6 fatty acid levels with BMI and waist circumference in the female healty subjects. Plasma ?6/?3 ratio of healthy male and female subjects was found as follows: 20.35 ± 14.7 and 20.16 ± 13.5 respectively. Conclusion: Plasma ?6/?3 ratio of healthy people living in our region is much higher than the rate recommended by world health organization. Furhermore, in this study show there is positive associations between BMI and waist circumference with plasma ?-6 fatty acid levels. Trigger many diseases, including obesity, the high ?-6 fatty acid content in the diet should be limited. Copyright © 2011 by Türkiye Klinikleri.Öğe The role of prohepcidin and hepcidin in anemia associated with systemic lupus erythematosus(2011) Dagli M.; Yilmaz S.; Sivrikaya A.; Cehk G.; Vatansev H.The aim of the study is to investigate the role of circulating prohepcidin and hepcidin, a homeostatic regulator of iron metabolism and a mediator of inflammation, in anemia associated with systemic lupus erythematosus(SLE) and differential diagnosis of iron deficiency anemia (IDA). Fourty patients with SLE (12 with anemia and 28 without anemia), 30 patients with IDA and 20 healthy adults were studied. Serum prohepcidin and hepcidin levels were analyzed by using a commercially available kits (DRG prohepcidin and hepcidin ELISA kits). Serum prohepcidin and hepcidin levels in patients with SLE were significantly higher than those with IDA and healthy group. In the group with IDA and SLE positive correlation was determined between the values of serum prohepcidin, hepcidin, Hb, TIBC and ferritin. Serum prohepcidin and hepcidin levels are not closely associated with disease activity in patients with SLE, but might play a role in the pathobiology of chronic disease anemia associated with SLE. © IDOSI Publications, 2011.Öğe Serum prohepcidin and hepcidin levels in patients with rheumatoid arthritis: A prospective study [Romatoid artritli hastalarda serum hepsidin ve prohepsidin düzeyleri: Prospektif çali{dotless}şma](Turkiye Klinikleri, 2013) Da?li M.; Sivrikaya A.; Yilmaz S.Objective: Anemia of chronic disease is a common feature of active rheumatoid arthritis. Hepcidin is an acute-phase protein with specific iron regulatory properties, which along with the anemia seen with increased hepcidin expression, have led many to consider it the major mediator of anemia of chronic disease. The aim of this study was to evaluate the serum levels of hepcidin and its prohormone, prohepcidin, in patients with rheumatoid arthritis (RA) in comparison with healthy controls. Material and Methods: Fifty patients with RA and twenty healthy adults were prospectively enrolled. Complete blood count, erythrocyte sedimentation rate, serum hepcidin, prohepcidin, iron, total iron binding capacity, ferritin, transferrin and C-reactive protein levels were measured. Results: Serum prohepcidin and hepcidin levels were significantly higher in patients with RA compared to healthy controls (p=0.010). In patients with RA, a positive correlation was determined between the serum hepcidin and prohepcidin levels (r=0.725, p<0.001). Conclusion: Our findings suggest that hepcidin and prohepcidin are strongly associated with disease activity in RA patients and might play a significant role in the pathobiology of anemia of chronic disease associated with RA. Future studies to determine serum levels of hepcidin at different time points during the clinical course of RA patients will be needed to confirm our results. © 2013 by Türkiye Klinikleri.Öğe Study of Elements, Antioxidants and Lipid Peroxidation in Hemodialysis Patients(2006) Menevşe E.; Sivrikaya A.; Karagözoğlu E.; Tiftik A. M.; Türk S.Background: During hemodialysis, most of the elements must be kept in a rather narrow physiological range, otherwise life-threatening events may occur. Furthermore, lipid peroxidation in patients may be partly due to the trace element disturbances. It has been mentioned that there are relations between deficiency in trace elements and antioxidant levels. The present study aimed to determine whether there were differences between hemodialysis patients and a healthy group according to selenium, aluminium, malondialdehyde (MDA), reduced form of glutathione (GSH) and superoxide dismutase (SOD) levels. Methods: The study included 47 hemodialysis patients (hemodialysis group). Blood samples were taken before (pre-hemodialysis) and after (post-hemodialysis) hemodialysis session. The control group included 23 healthy volunteers. Results: The aluminium, MDA, and SOD levels were lower and reduced form of GSH levels were higher in the control group when compared with the pre-hemodialysis group. MDA and SOD levels were higher in the posthemodialysis group than in the control group. GSH levels were lower and aluminium levels higher in the preversus the post-hemodialysis group. Conclusions: In order to evaluate the data of antioxidant and oxidant levels, hemodialysis patients are subjected to oxidative stress. Moreover, the study shows that analyzing levels of aluminium may be useful in hemodialysis patients in evaluating elements status.
