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Öğe Co-administration of cisplatin and curcumin does not alter mood-associated behaviors(COMENIUS UNIV, 2016) Demir, Enver Ahmet; Öz, Mehmet; Alp, Muhammed İkbal; Gergerlioğlu, Hasan Serdar; Atalık, Kısmet Esra Nurullahoğlu; Yerlikaya, Fatma HümeyraOBJECTIVES: Cisplatin (cis-diamminedichloroplatinum (II)) is a widely-used platinum-based chemotherapeutic agent which has dose-limiting side-effects. Also, the drug resistance is another instance that decreases treatment success in cisplatin chemotherapy. The growing body of evidence suggests that curcumin, a polyphenolic compound extracted from the spice turmeric, may exert synergistic effects and sensitize malign cells to cisplatin, while alleviating cytotoxicity-related side-effects. The present study was aimed to investigate mood-associated interactions between cisplatin and curcumin. MATERIALS AND METHODS: Thirty-four adult male Wistar albino rats were randomly assigned to four groups as control, curcumin (300 mg/kg/day, p.o. for 5 weeks), cisplatin (5 mg/kg/week, i.p. for 5 weeks), and curcumin plus cisplatin (same doses as above). The open field, elevated plus maze, and forced swim tests were engaged to evaluate mood-associated behaviors. RESULTS: We demonstrated that depression- and anxiety-like behaviors were not altered by the administration of curcumin along with the chronic cisplatin treatment. CONCLUSION: According to the results of the present study, we concluded that curcumin might be regarded as a safe adjuvant in cisplatin chemotherapy in terms of the mood-associated behaviors (Fig. 4, Ref 41).Öğe Effects of Cisplatin and Curcumin on the Hypothalamic-Pituitary-Adrenal Axis(WILEY-BLACKWELL, 2015) Öz, Mehmet; Demir, Enver Ahmet; Gergerlioğlu, Hasan Serdar; Atalık, Kısmet Esra Nurullahoğlu; Yerlikaya, Fatma Hümeyra[Abstract not Available]Öğe Effects of phototherapy on serum paraoxonase activity and total antioxidant capacity in newborn jaundice(Nobelmedicus, 2014) Kurban, Sevil; Annagür, Ali; Altunhan, Hüseyin; Mehmetoğlu, İdris; Örs, Rahmi; Erdem, Said Sami; Yerlikaya, Fatma HümeyraObjective: Phototherapy is an efficient and commonly used form of therapy for the treatment of neonatal hyperbilirubinemia. Paraoxonase 1 (PON1) is an antioxidative enzyme, which eliminates lipid peroxides. The aim of our study was to investigate the effect of phototherapy on serum PON1 activity and total antioxidant capacity (TAC) in hyperbilirubinemic full-term newborns.Material and Method: The study was performed on 40 full-term newborns between 3 to 15 days of age exposed to phototherapy.Serum PON1 activity and TAC levels of the babies were determinedbefore and after phototherapy by spectrophotometric assays.Results: We have found that PON1 activity was not significantly affected by phototherapy whereas TAC levels were decreased significantly after phototherapy (p<0.001).Conclusion: Our findings demonstrated that phototherapy has no direct effect on PON1 activity. Also, decreased TAC levels might have resulted from increased oxidative stress which may lead to consumption of antioxidant molecules. © 2014, Nobelmedicus. All rights reserved.Öğe EFFECTS OF PHOTOTHERAPY ON SERUM PARAOXONASE ACTIVITY AND TOTAL ANTIOXIDANT CAPACITY IN NEWBORN JAUNDICE(NOBEL ILAC, 2014) Kurban, Sevil; Annagür, Ali; Altunhan, Hüseyin; Mehmetoğlu, İdris; Örs, Rahmi; Erdem, Said Sami; Yerlikaya, Fatma HümeyraObjective: Phototherapy is an efficient and commonly used form of therapy for the treatment of neonatal hyperbilirubinemia. Paraoxonase 1 (PON1) is an anti oxidative enzyme, which eliminates lipid peroxides. The aim of our study was to investigate the effect of phototherapy on serum PON1 activity and total antioxidant capacity (TAC) in hyperbilirubinemic full-term newborns. Material and Method: The study was performed on 40 full-tenn newborns between 3 to 15 days of age exposed to phototherapy. SerumPON1 activity and TAC levels of the babies were determined before and after phototherapy by spectrophotometric assays. Results: We have found that PON1 activity was not significantly affected by phototherapy whereas TAC levels were decreased significantly after phototherapy (p<0.001). Conclusion: Our findings demonstrated that phototherapy has no direct effect on PON1 activity. Also, decreased TAC levels might have resulted from increased oxidative stress which may lead to consumption of antioxidant molecules.Öğe Effects of the Environmental Enrichment on Learning and Memory in High-Fat Diet-Fed Rats(WILEY-BLACKWELL, 2015) Öz, Mehmet; Demir, Enver Ahmet; Gergerlioğlu, Hasan Serdar; Atalık, Kısmet Esra Nurullahoğlu; Yerlikaya, Fatma Hümeyra[Abstract not Available]Öğe Environmental enrichment reverses cognitive impairments provoked by Western diet in rats: Role of corticosteroid receptors(PERGAMON-ELSEVIER SCIENCE LTD, 2016) Gergerlioğlu, Hasan Serdar; Öz, Mehmet; Demir, Enver Ahmet; Atalık, Kısmet Esra Nurullahoğlu; Yerlikaya, Fatma HümeyraAims: Previous studies demonstrated that the Western diet (WD), which is rich in saturated fat (HFD) and refined sugar (HSU), is related to the impairments of hippocampus-dependent learning and memory and forebrain synaptic plasticity in rodents. The environmental enrichment (EE) has been shown to enhance learning and memory in theHFD-induced cognitive deficits, but the exact mechanismis still not clearly understood. Therefore, the present study aimed to clarify the effects of the EE on spatial memory in WD-fed rats, and to analyze the potential role of corticosteroid receptors in the EE conditioning. Main methods: MaleWistar albino rats were housed in either an enriched or standard environment and fed with the HFD (35% of energy as fat), HSU (100% of carbohydrate as sucrose) or standard rat chowfor 4 weeks. Weused the Morris' water maze test (MWM) to assess the learning and memory performance, and measured plasma levels of corticosterone (CORT) and adrenocorticotropic hormone (ACTH), as well as glucocorticoid (GR) and mineralocorticoid receptor (MR) levels in the hippocampus. Key findings: The results showed that HFD-fed rats displayed poorer learning and memory performance evaluated with MWM than controls. The EE reversed the cognitive deficits caused by the HFD. In addition, the EE resulted in an increase of GR and MR levels without affecting plasma CORT and ACTH concentrations. Significance: Based on these findings, it could be suggested that the EE plays an important role in amelioration of the HFD-induced cognitive impairments, but this intervention is independent of the hypothalamic-pituitaryadrenal axis and hippocampal corticosteroid receptor levels. (C) 2016 Elsevier Inc. All rights reserved.Öğe Hipotalamik-hipofizer-adrenal Aks Üzerine Sisplatin ve Kurkuminin Etkileri(Selçuk Üniversitesi, 2017 Mart) Öz, Mehmet; Demir, Enver Ahmet; Gergerlioğlu, Hasan Serdar; Atalık, Kısmet Esra Nurullahoğlu; Yerlikaya, Fatma HümeyraAmaç: Son yıllarda zerdeçaldaki aktif polifenol olan kurkumininsisplatin içeren kemoterapi rejimlerinde sinerjistik bir role sahip olduğunu gösteren bilgiler artmaktadır. Kurkuminin güvenli bir adjuvan olduğunu göstermek için söz konusu ajanların sistemik etkileşimlerinin araştırılması gerektiğinden bu polifenolünsisplatin uygulanan sıçanlarda hipotalamik-hipofizer-adrenal (HPA) aksa etkilerinin incelemesi amaçlandı. Gereç ve Yöntem: Toplamda 34 erkek Wistar sıçan kontrol (n=7), sisplatin (n=10), kurkumin(n=7) ve sisplatin + kurkumin (n=10) olmak üzere dört gruba ayrıldı. Sisplatin ve kurkumin gruplarındaki sıçanlara 5 hafta süresince (sırasıyla) 5 mg/kg/hafta, i.p. sisplatin ve 300 mg/ kg/gün, p.o. kurkumin uygulandı. Sisplatin + kurkumin grubu aynı dozlarda hem sisplatin hem kurkumin aldı. Kontrol grubuna yalnızca taşıyıcı (fizyolojik salin ve mısır yağı) verildi. Hayvanlar adrenokortikotropik hormon (ACTH) ve kortikosteron (CORT) ölçümleri için kan elde etmek maksadıyla eksanguine edildi. Beyin çıkarıldı ve hipokampal dokuda mineralokortikoid (MR) ve glukokortikoid (GR) reseptörleri belirlendi. Analizler ELISA yöntemiyle gerçekleştirildi. Bulgular: Sisplatin ve kurkumin tedavilerinin araştırılan parametreleri bozmadığını bulduk (p>0.05). Ayrıca, kurkumin ve sisplatinin birlikte uygulanmasının kontrollere kıyasla ACTH ve CORT’un plazma konsantrasyonları ile hipokampal MR ve GR seviyelerini değiştirmediğini gözlendi (p>0.05). Sonuç: Sonuçlarımıza göre tek başına veya kombine halde sisplatin ve kurkumin tedavisi HPA aksını etkilememektedir.Öğe Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-beta peptide in high-fat and high-sucrose-fed rats(CAMBRIDGE UNIV PRESS, 2017) Selvi, Yavuz; Gergerlioğlu, Hasan Serdar; Akbaba, Nursel; Öz, Mehmet; Kandeğer, Ali; Demir, Enver Ahmet; Yerlikaya, Fatma HümeyraObjective: The Western-type diet is associated with an elevated risk of Alzheimer's disease and other milder forms of cognitive impairment. The aim of the present study was to investigate the effects of the environmental enrichment on amyloid and tau pathology in high-fat and high-sucrose-fed rats. Methods: In total, 40 adult male rats were categorised into two main groups according to their housing conditions: enriched environment (EE, n = 16) and standard housing condition (n = 24). The groups were further divided into five subgroups that received standard diet, high-fat diet, and high-sucrose diet. We performed the analysis of amyloid beta-peptide (A beta) (1-40), A beta(1-42), amyloid precursor protein (APP), and tau levels in the hippocampus of rats that were maintained under standard housing conditions or exposed to an EE. Results: The EE decreased the A beta(1-40), A beta(1-42), APP, and tau levels in high-fat and high-sucrose-fed rats. Conclusion: This observation shows that EE may rescue diet-induced amyloid and tau pathology.Öğe Ischaemia-modified albumin levels in newborn jaundice before and after phototherapy(WILEY, 2011) Erdem, Said Sami; Kurban, Sevil; Altunhan, Hüseyin; Annagür, Ali; Örs, Rahmi; Yerlikaya, Fatma Hümeyra; Gökçe, ReşatThe aim of our study was to assess the effect of phototherapy (PT) on ischaemia-modified albumin (IMA) and malondialdehyde (MDA) levels in hyperbilirubinemic full-term newborns. The study was performed on 36 full-term infants exposed to PT. The babies were aged 3 to 13 days. IMA and MDA levels of the babies were determined before and after PT, by a colorimetric assay. IMA levels before and after PT were found as 0.424 +/- 0.290 and 0.531 +/- 0.262 absorbance units, respectively. Although IMA levels after PT were slightly higher, the difference was not statistically significant (p > 0.131). MDA levels before and after PT were found as 8.4 +/- 1.8 mu mol/l and 9.4 +/- 1.5 mu mol/l, respectively. Serum MDA concentrations were significantly higher after PT than before PT (p < 0.000). In previous studies, conflicting findings have been reported about the effect of PT on oxidant and antioxidant systems. However, we have found no study investigating IMA levels in hyperbilirubinaemia in newborns before and after PT. Our results shows that PT does not affect IMA levels significantly. IMA increases as a result of oxidative stress. We believe that the lack of significant difference between our IMA levels before and after PT may resulted from hyperbilirubinaemia, which has antioxidant effect. Copyright (C) 2011 John Wiley & Sons, Ltd.Öğe Obez kişilerde ve sağlıklı kontrollerde kan serbest yağ asitleri, koenzim Q10 ve fetuin A düzeylerinin araştırılması(Selçuk Üniversitesi Sağlık Bilimleri Enstitüsü, 2010) Yerlikaya, Fatma Hümeyra; Mehmetoğlu, İdrisBu çalışma, toplam 18-70 yaşları arasında 105 (22E,83K) obez ve 18-70 yaşları arasında 80 (20E,60K) sağlıklı kontrol vakası üzerinde gerçekleştirildi. Obez kişilerin obezite dışında bilinen hiçbir klinik şikayeti ve bulgusu (diabetes mellitus, hipertansiyon vs.) olmamasına dikkat edildi. Obezite kriteri olarak vücut kitle indeksi (VKİ) kullanıldı. Obez kişilerde VKİ değeri 35 kg/m2' den büyük, sağlıklı kontrollerde VKİ değeri 25 kg/m2' dan küçüktü. Gruplardan alınan plazma örneklerinde serbest yağ asitleri, serum örneklerinde ise koenzim Q10 ve fetuin-A düzeyleri ölçüldü. Yağ asitleri düzeyleri GS-MS yöntemi ile, koenzim Q10 HPLC yöntemi ile ve fetuin-A düzeyleri ticari kit kullanılarak ELİZA metodu ile ölçüldü. Obezlerde miristik asit, palmitik asit, palmitoleik asit, 10c-heptadecanoik asit, linoleik asit ve heneikosanoik asit düzeyleri kontrol grubuna göre önemli düzeyde (p<0,05) yüksek, behenik asit düzeyleri ise kontrol grubuna göre önemli düzeyde (p<0,05) düşük bulundu. Yine çalışmamızda obez kişilere ait SFA düzeyleri kontrol grubuna göre anlamlı derecede yüksek (p<0,01) bulundu. Her iki gruba ait MUFA, PUFA ?-3,?-6 ve konjuge linoleik asit düzeyleri arasında önemli bir fark bulunamadı. Obezlerde ?-9-Desatüraz (D9D) aktivitesi kontrollere göre anlamlı derecede yüksek ve elongaz aktivitesi anlamlı derecede düşük bulundu(p<0,01). Obez kişilerle kontrol grubuna ait koenzim Q10 (CoQ10) ve fetuin-A düzeyleri arasında istatistiki açıdan önemli bir fark bulunamadı. Obez kişilerde CoQ10 düzeyi ile VKİ ve bel çevresi arasında, CoQ10 ile bazı yağ asitleri arasında ve CoQ10 ile yaş arasında önemli pozitif ilişki bulundu. Obezlere ait fetuin-A düzeyi ile bazı yağ asitleri arasında negatif korelasyon, kontrol grubunda ise pozitif korelasyonlar bulundu. Bütün bu bulgulardan çalışmamızdan aşağıdaki önemli sonuçlara varıldı: 1. Obez kişilerde bazı yağ asitlerinin düzeyinin kontrollere göre önemli oranda yüksek, behenik asit düzeyinin ise düşük bulunmasının nedeni ve bunun obezite açısından nasıl bir risk oluşturduğu bilinmemekte ve araştırılması gerekmektedir. 2. Obez kişilerde kontrollere göre anlamlı derecede yüksek bulunan SFA düzeyi bu kişilerde başta kalp-damar hastalıkları olmak üzere çeşitli hastalıklar açısından önemli risk oluşturmakta ve kontrol edilmesi gerekmektedir. 3. Bölgemizde yaşayan obez ve sağlıklı kişilerin ?-3 ve ?-6 yağ asitleri ile oleik asit düzeylerinin literatürde bildirilen diğer gelişmiş toplumlarınkine göre daha düşük olduğu görüldü. Bu bulgu üzerinde önemle durulması gereken bir sağlık sorunu olup toplum bu konuda bilgilendirilmelidir. 4. Kontrol grubunda serum fetuin-A düzeyi ile bazı yağ asitleri düzeyi arasında bulunan pozitif korelasyon beklenen bir bulgu iken obezlerde aynı parametre ile bazı yağ asitleri düzeyi arasında bulunan negatif korelasyonun sebebi bilinmemekte ve daha ileri araştırılması gerekmektedir. 5. Obez kişilerde CoQ10 düzeyleri ile VKİ, bel çevresi ve yaş arasında pozitif korelasyon bulunmasının bu kişilerdeki fazla yağ dokusu ve artmış oksidatif stresin bir sonucu olduğuna inanmaktayız. Ancak, aynı kişilerde serum CoQ düzeyi ile bazı yağ asitleri düzeyi arasında bulunan pozitif korelasyonların nedeni bilinmemekte ve daha ileri araştırılması gerekmektedirÖğe The Relationship Between Neutrophil-to-lymphocyte Ratio and Inflammation in End-Stage Renal Disease Patients(INFORMA HEALTHCARE, 2012) Türkmen, Kültigin; Güney, İbrahim; Yerlikaya, Fatma Hümeyra; Tonbul, Halil ZekiBackground: Patients with end-stage renal disease (ESRD) have elevated serum levels of inflammatory mediators including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and interleukin (IL)-6. Systemic inflammation was found to be correlated with coronary artery disease (CAD) in this population. Neutrophil-to-lymphocyte ratio (NLR) was introduced as a potential marker to determine inflammation in cardiac and non-cardiac disorders. Data regarding NLR and its association with inflammation are lacking. We aimed to determine the relationship between NLR and inflammation in ESRD patients. Material and methods: This was a cross-sectional study involving 61 ESRD patients (25 females and 36 males; mean age: 48.3 +/- 14.5 years) receiving peritoneal dialysis (PD) or hemodialysis (HD) for >= 6 months in the Dialysis Unit of Selcuk University. NLR, CRP, TNF-alpha, and IL-6 levels were measured. Results: NLR, serum CRP, IL-6, and TNF-alpha levels were significantly higher in PD patients when compared with HD patients. ESRD patients with NLR >= 3.5 had significantly higher TNF-alpha levels when compared with patients with NLR < 3.5. In the bivariate correlation analysis, NLR was positively correlated with TNF-alpha in this population. Conclusions: Simple calculation of NLR can predict inflammation in ESRD patients.Öğe The Relationship Between Plasma MicroRNAs and Serum Mercury Levels in Patients with Amalgam Filling and Dentists(Selçuk Üniversitesi, 2021) Tunçdemir, Makbule Tuğba; Yerlikaya, Fatma HümeyraBackground: The aim of this study was to investigate the relationship between serum mercury and some plasma microRNA (miRNA) levels associated with neurological diseases in patients with amalgam filling and dentists. Methods: This study included 30 patients with amalgam filling, 30 dentists, and 30 healthy individuals as the control group. Circulating plasma miRNAs (124-3p, 125-5p, and 127-3p) were evaluated using real-time quantitative polymerase chain reaction analysis. The serum mercury levels were measured using inductively coupled plasma-mass spectrometry. ANOVA and Tukey’s multiple comparison tests were used for statistical analyses (? =.05). Results: A significant difference in serum mercury and plasma miRNA levels was found between the groups. Significant positive correlations between serum mercury and plasma miRNA 125-5p and 127-3p levels were detected in the patient group (r: 0.56 and r: 0.39, respectively). Serum mercury and plasma miRNA-125-5p levels showed a positive correlation in the dentist group (r: 0.37). Conclusion: Having amalgam filling caused a significant increase in serum mercury and some plasma miRNA levels (124-3p, 125-5p, and 127-3p). The presence of a positive correlation suggests that sensitivity to neurological diseases may increase because of mercury exposure. Alternative restorative materials should be preferred for amalgam filling and amalgam fillings should be replaced with other restorative materials under necessary preventions.Öğe Serum ischemia-modified albumin levels at diagnosis and during treatment of late-onset neonatal sepsis(TAYLOR & FRANCIS LTD, 2014) Yerlikaya, Fatma Hümeyra; Kurban, Sevil; Mehmetoğlu, İdris; Annagür, Ali; Altunhan, Hüseyin; Erbay, Ekrem; Örs, RahmiSepsis is one of the most common infectious conditions in the neonatal period, and continues as a major source of morbidity and mortality. The aim of this study is to determine serum ischemia-modified albumin (IMA) levels in late-onset neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow-up. Also, it is aimed to compare serum IMA levels with serum C-reactive protein (CRP), procalcitonin (PCT) levels and white blood cell count. The study was performed on 33 premature babies with sepsis and 21 healthy premature controls at 7-28 days of age. In the sepsis group, biochemical parameters and blood culture samples were obtained from the blood at the onset and on the fifth day of treatment for each patient. Serum IMA, CRP, PCT and white blood cell count were significantly higher in the sepsis group before treatment when compared with the control group. In addition, the levels of IMA were positively correlated with white blood cell count, CRP and PCT in the sepsis group before treatment. In conclusion, serum IMA levels may be useful in late-onset neonatal sepsis at the time of diagnosis and after therapy. As far as we know this is the first report about the assesment of illness diagnosis and after therapy using serum IMA levels, and further studies are needed to confirm our results in larger groups of patients.
