The Relationship Between Neutrophil-to-lymphocyte Ratio and Inflammation in End-Stage Renal Disease Patients
Yükleniyor...
Dosyalar
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
INFORMA HEALTHCARE
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Patients with end-stage renal disease (ESRD) have elevated serum levels of inflammatory mediators including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and interleukin (IL)-6. Systemic inflammation was found to be correlated with coronary artery disease (CAD) in this population. Neutrophil-to-lymphocyte ratio (NLR) was introduced as a potential marker to determine inflammation in cardiac and non-cardiac disorders. Data regarding NLR and its association with inflammation are lacking. We aimed to determine the relationship between NLR and inflammation in ESRD patients. Material and methods: This was a cross-sectional study involving 61 ESRD patients (25 females and 36 males; mean age: 48.3 +/- 14.5 years) receiving peritoneal dialysis (PD) or hemodialysis (HD) for >= 6 months in the Dialysis Unit of Selcuk University. NLR, CRP, TNF-alpha, and IL-6 levels were measured. Results: NLR, serum CRP, IL-6, and TNF-alpha levels were significantly higher in PD patients when compared with HD patients. ESRD patients with NLR >= 3.5 had significantly higher TNF-alpha levels when compared with patients with NLR < 3.5. In the bivariate correlation analysis, NLR was positively correlated with TNF-alpha in this population. Conclusions: Simple calculation of NLR can predict inflammation in ESRD patients.
Açıklama
Anahtar Kelimeler
End-Stage Renal Disease, Inflammation, Neutrophil-to-Lymphocyte Ratio
Kaynak
Renal Failure
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
34
Sayı
2
Künye
Türkmen, K, Güney, İ., Yerlikaya, F. H., Tonbul, H. Z., (2012). The Relationship Between Neutrophil-to-lymphocyte Ratio and Inflammation in End-Stage Renal Disease Patients. Renal Failure, 34(2), 155-159. DOI: 10.3109/0886022X.2011.641514
