Thyroid hormone levels during early periods of ischemic and hemorrhagic stroke could serve as an indicator of prognosis

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dc.contributor.authorAyşegül, Bayır
dc.contributor.authorAhmet, Ak
dc.contributor.authorŞerife, Özdinç
dc.contributor.authorSeydanoğlu, Abdüsselam
dc.contributor.authorKöstekci, Şenol Kadir
dc.contributor.authorFatih, Kara
dc.date.accessioned2020-03-26T17:40:57Z
dc.date.available2020-03-26T17:40:57Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBACKGROUND: Predicting the outcome of stroke during the acute phase is difficult. Accurate methods for predicting outcomes could assist clinicians and families to make correct decisions in resource-poor environments. OBJECTIVE: To determine thyroid hormone levels in patients with ischemic or hemorrhagic stroke at the early stage, and to investigate its correlation with stroke prognosis. DESIGN, TIME AND SETTING: A comparative, observational study was performed at the Department of Emergency, Tertiary-care University Affiliated Hospital from January 2004 to January 2006. PARTICIPANTS: A total of 113 patients presenting to the Emergency Department within 3 hours of stroke symptom onset were approached for enrollment in the study. The patients were diagnosed by computer tomography examination, and comprised 87 ischemic stroke and 26 hemorrhagic stroke patients. METHODS: Following a thorough history and examination by emergency physicians, venous blood samples were collected from each patient. Thyroid-stimulating hormone (TSH), free triiodothyronine (free T3), and free thyroxine (free T4) levels were measured using a chemiluminescence method. The nerve function of patients was evaluated with Glasgow Coma Scale (GCS) score, and the patients were accordingly assigned to two subgroups-mild stroke (GCS >= 9) and severe stroke (GCS <= 8). MAIN OUTCOME MEASURES: Blood levels of TSH, tree T3 and free T4; mortality at 7 days. RESULTS: Mean TSH values in hemorrhagic stroke patients with GCS <= 8 were significantly greater than those in ischemic stroke patients with GCS <= 8 and GCS >= 9 (P < 0.05). Compared with patients who survived, the highest TSH levels were detected in patients that had died within 7 days. Correlation analysis results revealed a significant negative relationship between GCS values and TSH levels in patients with hemorrhagic stroke (r = -0.552, P < 0.01), and no correlation was determined between GCS values and TSH levels in patients with ischemic stroke (r = 0.239, P > 0.05). CONCLUSION: In patients with hemorrhagic stroke, high TSH levels were observed within the first 3 hours of stroke onset, which could be considered an indicator of poor prognosis.en_US
dc.identifier.doi10.3969/j.issn.1673-5374.2009.09.003en_US
dc.identifier.endpage662en_US
dc.identifier.issn1673-5374en_US
dc.identifier.issn1876-7958en_US
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage659en_US
dc.identifier.urihttps://dx.doi.org/10.3969/j.issn.1673-5374.2009.09.003
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23986
dc.identifier.volume4en_US
dc.identifier.wosWOS:000270690300003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMEDKNOW PUBLICATIONS & MEDIA PVT LTDen_US
dc.relation.ispartofNEURAL REGENERATION RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIschemic strokeen_US
dc.subjectHemorrhagic strokeen_US
dc.subjectThyroid hormonesen_US
dc.subjectPrognosisen_US
dc.titleThyroid hormone levels during early periods of ischemic and hemorrhagic stroke could serve as an indicator of prognosisen_US
dc.typeArticleen_US

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