An Ariadne's Thread to the Identification and Annotation of Noncoding RNAs in Eukaryotes

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Küçük Resim

Tarih

2009

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Oxford University Press

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Non-protein coding RNAs (ncRNAs) have emerged as a vast and heterogeneous portion of eukaryotic transcriptomes. Several ncRNA families, either short (<200 nucleotides, nt) or long (>200 nt), have been described and implicated in a variety of biological processes, from translation to gene expression regulation and nuclear trafficking. Most probably, other families are still to be discovered. Computational methods for ncRNA research require different approaches from the ones normally used in the prediction of protein-coding genes. Indeed, primary sequence alone is often insufficient to infer ncRNA functionality, whereas secondary structure and local conservation of portions of the transcript could provide useful information for both the prediction and the functional annotation of ncRNAs. Here we present an overview of computational methods and bioinformatics resources currently available for studying ncRNA genes, introducing the common themes as well as the different approaches required for long and short ncRNA identification and annotation.

Açıklama

Anahtar Kelimeler

Bioinformatics analysis, Bioinformatics programming, Gene prediction, Genome annotation, Regulatory RNA, Small and long noncoding RNA

Kaynak

Briefings in Bioinformatics

WoS Q Değeri

Scopus Q Değeri

Q1

Cilt

10

Sayı

5

Künye

Guffanti, A., Corti, G., Corradin, A., Sezerman, O. U., Makunin, I.V., Soldà, G., (2009). An Ariadne's Thread to the Identification and Annotation of Noncoding RNAs in Eukaryotes. Briefings in Bioinformatics, 10(5), 475-489. Doi: 10.1093/bib/bbp022