A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L.

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dc.contributor.authorCvetanovic, Aleksandra
dc.contributor.authorZekovic, Zoran
dc.contributor.authorSvarc-Gajic, Jaroslava
dc.contributor.authorRazic, Slavica
dc.contributor.authorDamjanovic, Ana
dc.contributor.authorZengin, Gökhan
dc.contributor.authorDelerue-Matos, Cristina
dc.date.accessioned2020-03-26T19:52:44Z
dc.date.available2020-03-26T19:52:44Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBACKGROUND: To obtain bioactive fractions from plant material subcritical water is notably advantageous in comparison to any other technique. Excellent solvating properties and selectivity combined with finely tuned reactivity of subcritical water enable exploitation of the potential of plants. Herein subcritical water extraction was used for recovery of bioactive compounds from leaves, roots and fruits of Sambucus ebulus L. Extracts obtained were characterized in terms of biological and chemical fingerprints. RESULTS AND DISCUSSIONR: esults obtained by using several antioxidant assays that focused on different mechanisms showed that subcritical water extracts of Sambucus ebulus were powerful antioxidants. Enzyme inhibitory effects were tested against alpha-amylase, alpha-glucosidase and tyrosinase, and the results showed the anti-diabetic potential of the extracts as well as its possible use with skin disorders. Antiproliferative properties were detected on three cell lines (A-549; LS-174 T; HeLa) and showed prominent cytotoxicity against all tumor cell lines. Inhibitory concentrations obtained were in the range 0.58-8.10 mu g mL(-1). Generally, the SCW extracts from leaves exhibited stronger biological activities with higher levels of phenolic compounds compared with the roots and fruits of Sambucus ebulus. Gallic acid, catechin and caffeic acid were identified as major components in these extracts and these components seem to relate with observed biological activity. CONCLUSION: The results obtained suggest that Sambucus ebulus has great potential for preparing new phyto-pharmaceuticals and functional food ingredients. (C) 2017 Society of Chemical Industry.en_US
dc.description.sponsorshipRepublic of Serbia [451-03-01765/2014-09/28]; Portuguese RepublicPortuguese Foundation for Science and Technology [451-03-01765/2014-09/28]; Serbian Ministry of Education, Science and Technological Development [TR31013, III43009, 175011]; POPH-QREN - Tipologia 4.1 - Formacao Avancada [SFRH/BPD/97049/2013]; Fundo Social Europeu; Ministerio da Ciencia, Tecnologia e Ensino Superior; FCT/MEC; FEDEREuropean Union (EU) [UID/ QUI/50006/2013 - POCI/01/0145/FERDER/007265]en_US
dc.description.sponsorshipThe present work is part of the research conducted within the bilateral cooperation between the Republic of Serbia and Portuguese Republic (Project No. 451-03-01765/2014-09/28) and within the projects of the Serbian Ministry of Education, Science and Technological Development, (Projects No. TR31013, III43009 and 175011). Manuela M. Moreira (SFRH/BPD/97049/2013) is grateful for the postdoctoral fellowships financed by POPH-QREN - Tipologia 4.1 - Formacao Avancada, subsidized by Fundo Social Europeu and Ministerio da Ciencia, Tecnologia e Ensino Superior. The authors are also grateful for the financial support from FCT/MEC through national funds and co-financed by FEDER, under the Partnership Agreement PT2020 through the project UID/ QUI/50006/2013 - POCI/01/0145/FERDER/007265.en_US
dc.identifier.doi10.1002/jctb.5468en_US
dc.identifier.endpage1104en_US
dc.identifier.issn0268-2575en_US
dc.identifier.issn1097-4660en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1097en_US
dc.identifier.urihttps://dx.doi.org/10.1002/jctb.5468
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36268
dc.identifier.volume93en_US
dc.identifier.wosWOS:000426859900018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectextractionen_US
dc.subjectpharmaceuticalsen_US
dc.subjectsupercritical fluidsen_US
dc.subjectsubcritical water extractionen_US
dc.subjectplanten_US
dc.titleA new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L.en_US
dc.typeArticleen_US

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