Safety of an antiprotozoal drug combination in sheep
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Dosyalar
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi Veterinerlik Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmanın amacı kan parazitlerine karşı kullanılan imidokarb, buparvaquon ve oksitetrasiklinin koyunlarda maksimum doz ve sürede kombine kullanımının olası yan etkilerini belirlemektir. Gereç ve Yöntem: Araştırmada 10 adet koyuna imidokarb (2.4 mg/ kg), buparvaquon (2.5 mg/kg) ve oksitetrasiklin (20 mg/kg) birlikte kas içi yolla 3 gün ara ile iki kez uygulandı. Kan örnekleri uygulama öncesi (0 kontrol) ve sonrası 0.5, 1, 2, 3, 4, 5 ve 6. günler alındı. Malondialdehid, 8-hidroksi-2-deoksiguanosin, troponin I ve kreatin kinaz-MB isoenzim düzeyleri ELISA okuyucusunda belirlenirken, kalp, karaciğer ve böbrek fonksiyon parametreleri otoanalizörde ölçüldü. Ayrıca kan gazları ve hemogram parametreleri ölçüldü. Bulgular: Uygulama sonrası koyunlarda oksidatif stres belirlenmezken (p>0.05), laktat dehidrogenaz, aspartat aminotransferaz, alanin aminotransferaz, kan üre nitrojen ile glikoz düzeylerinde artışlar belirlendi (p<0.05). Alkalen fosfataz, akyuvar sayısı ve sodyum düzeylerinde düşmeler gözlenirken (p<0.05), hemoglobin, bikarbonat, potasyum, iyonize kalsiyum ve klor düzeylerinde istatistiki dalgalanmalar belirlendi (p<0.05). Öneri: Koyunlara imidokarb, buparvaquon ve oksitetrasiklinin kombine uygulamasının ciddi oksidatif stres, kardiyotoksisite ve nefrotoksisiteye neden olmadığı, fakat bu kombinasyonun karaciğer fonksiyonu ile kan gazları ve hemogram parametrelerini etkileyebileceği ifade edilebilir. Ancak hasta hayvanlarda bu kombinasyonun kullanılmasında dikkatli olunmalıdır
Aim: The aim of this study was to determine the possible side effects in sheep of combined administration of imidocarb, buparvaquone, and oxytetracycline, which are antiprotozoal drugs against bloodborne parasites, at the maximum dose and treatment period. . Materials and Methods: Imidocarb (2.4 mg/kg), buparvaquone (2.5 mg/kg), and oxytetracycline (20 mg/kg) were administered simultaneously by intramuscular injection to 10 sheep, and a second combined dose was administered 3 days later. Blood samples were taken before (0 control) and at 0.5, 1, 2, 3, 4, 5, and 6 days after drug administrations. Malondialdehyde, 8-hydroxy-2?-deoxyguanosine, troponin I, and creatine kinase-MB isoenzyme levels were determined with ELISA reader, and cardiac, hepatic, and renal damage markers were measured with autoanalyzer. Blood gas and hemogram parameters were also determined. Results: No oxidative stress (p>0.05) was observed in the sheep, whereas increased (p<0.05) lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, and glucose levels were determined. Although decreased (p<0.05) alkaline phosphatase, white blood cell counts, and sodium levels were measured, statistically significantly fluctuations were observed (p<0.05) in hemoglobin, bicarbonate, potassium, ionized calcium, and chlorine levels. Conclusion: The combination of imidocarb, buparvaquone, and oxytetracycline have not cause serious oxidative damage, cardiotoxicity, and nephrotoxicity in sheep, but this combination may show transient effects on liver function and blood gas and hemogram values. Therefore, caution should be exercised when using this combination in infected sheep.
Aim: The aim of this study was to determine the possible side effects in sheep of combined administration of imidocarb, buparvaquone, and oxytetracycline, which are antiprotozoal drugs against bloodborne parasites, at the maximum dose and treatment period. . Materials and Methods: Imidocarb (2.4 mg/kg), buparvaquone (2.5 mg/kg), and oxytetracycline (20 mg/kg) were administered simultaneously by intramuscular injection to 10 sheep, and a second combined dose was administered 3 days later. Blood samples were taken before (0 control) and at 0.5, 1, 2, 3, 4, 5, and 6 days after drug administrations. Malondialdehyde, 8-hydroxy-2?-deoxyguanosine, troponin I, and creatine kinase-MB isoenzyme levels were determined with ELISA reader, and cardiac, hepatic, and renal damage markers were measured with autoanalyzer. Blood gas and hemogram parameters were also determined. Results: No oxidative stress (p>0.05) was observed in the sheep, whereas increased (p<0.05) lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, and glucose levels were determined. Although decreased (p<0.05) alkaline phosphatase, white blood cell counts, and sodium levels were measured, statistically significantly fluctuations were observed (p<0.05) in hemoglobin, bicarbonate, potassium, ionized calcium, and chlorine levels. Conclusion: The combination of imidocarb, buparvaquone, and oxytetracycline have not cause serious oxidative damage, cardiotoxicity, and nephrotoxicity in sheep, but this combination may show transient effects on liver function and blood gas and hemogram values. Therefore, caution should be exercised when using this combination in infected sheep.
Açıklama
Anahtar Kelimeler
İmidokarb, Buparvaquon, Oksitetrasiklin, Güvenilirlik, Koyun, Imidocarb, Buparvaquone, Oxytetracycline, Safety, Sheep
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
36
Sayı
2
Künye
İder, M., Naseri, A., Parlak, T. M., Zhunushova, A., Yazar, E., (2020). Safety of an antiprotozoal drug combination in sheep. Eurasian Journal of Veterinary Sciences, 36 (2), 115-120. DOI: 10.15312/EurasianJVetSci.2020.268
