Comparison of intranasal midazolam and midazolam-sufentanil for premedication in children [Çocuklarm premedikasyonunda i?ntranazal midazolam ve midazolam-sufentanilin karşilaştirilmasi]

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Aim: We aimed to compare the effect of midazolam and the combination of low dose of midazolam and sufentanil applied intranasal on sedation, hemodynamic parameters and recovery in children for premedication. Materials and Methods: 50 children scheduled for elective tonsillectomy and/or adenoidectomy were randomized into two groups: Group M (n=25): received midazolam 0.2 mg kg -1, Group M/S (n=25): received 0.1 mg kg-1 midazolam plus 0.75 ?g kg-1 sufentanil intranasal 20 minutes before anesthesia induction. Mean arterial pressure, heart rate, pulse oximetry and Ramsey sedation scores were recorded before and after premedication. The moods of children at the time of separation from parents are recorded as silence or not. The response to venous canulation was assessed operation desk. Anesthesia induction was provided with % 8 sevoflurane in 50 % O2-50 % N 2O and 10 ?g kg-1 alfentanil. The response to face mask was evaluated as accept/deny. Anesthesia was maintained with % 2-3 sevoflurane in 50 % O2-50 % N2O mixture. Postoperative agitation and pain level were determined with Davis Score and POPS respectively. Results: There were no difference in hemodynamic parameters between the groups (p>0.05). Children's mood at the time of seperating from parents, response to face mask, POPS and Davis scores at postoperative 30th minute in Group M, response to venous canulation in Group M/S were significally better (p<0.05). There were no significant difference with respect to Davis and POPS scores measured at postoperative 10th minutes (p>0.05). Conclusions: Midazolam-sufentanil combination used in this study was not found to be a good alternative to midazolam only.


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Intranasal, Midazolam, Premedication, Sufentanil


Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi

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