Multidirectional Approaches on Autofermented Chamomile Ligulate Flowers: Antioxidant, Antimicrobial, Cytotoxic and Enzyme Inhibitory Effects

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dc.authorid0000-0002-8901-6484
dc.contributor.authorCvetanovic, Aleksandra
dc.contributor.authorZekovic, Zoran
dc.contributor.authorZengin, Gökhan
dc.contributor.authorMaskovic, Pavle
dc.contributor.authorPetronijevic, Mirjana
dc.contributor.authorRadojkovic, Marija
dc.date.accessioned2020-03-26T20:15:18Z
dc.date.available2020-03-26T20:15:18Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractIn the frame of the present paper the enzymatic transformation of apigenin-glucosides into free aglycone was achieved by autofermentation of chamomile ligulate flowers (CLF). Antioxidant properties of the autofermented CLF (A-CLF) extract were evaluated by their radical scavenging activity against hydroxyl radicals and inhibition of lipid peroxidation. Obtained results showed that A-CLF extract in a concentration of 0.84 mg/mL was able to inhibit 50% of hydroxyl radicals, while IC50 value in the case of inhibition of lipid peroxidation was 5.21 mg/mL. Antimicrobial activity was done by measuring minimal inhibitory concentration (MIC) values for eight microbial strains. Obtained MIC values (9.75-156.25 mu g/mL) confirmed high antibacterial and antifungal activities of the extract. Cytotoxic activity was done by using three histological different cell lines: Hep2C; RD and L2OB. Obtained IC50 values for these cell lines were: 28.72; 17.31 and 10.92, respectively. Furthermore, in vitro investigation of the A-CLF ability to inhibit selected enzymes (alpha-amylase, alpha-glucosidase, tyrosinase) was done as well. Determined activities against alpha-amylase and alpha-glucosidase were 0.94 and 3.24 mmol ACAE/g, respectively. Further, measured activity against tyrosinase was 0.69 mg KAEs/g indicating high enzyme-inhibitory activity of examined sample. Results demonstrated that A-CLF extracts showed considerable pharmacological activity. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipMinistry of Education, Science and Technological Development of the Republic of Serbia [TR31013]en_US
dc.description.sponsorshipThe present work was carried out within the projects of the Ministry of Education, Science and Technological Development of the Republic of Serbia, (Projects No. TR31013). The authors are grateful to Dr. Dusan Adamovic, Institute of Field and Vegetable Crops, Backi Petrovac, Serbia, for his support in supplying plant material.en_US
dc.identifier.citationCvetanović, A., Zeković, Z., Zengin, G., Mašković, P., Petronijević, M., Radojković, M. (2019). Multidirectional Approaches on Autofermented Chamomile Ligulate Flowers: Antioxidant, Antimicrobial, Cytotoxic and Enzyme Inhibitory Effects. South African Journal of Botany, 120, 112-118. doi: https://dx.doi.org/10.1016/j.sajb.2018.01.003
dc.identifier.doi10.1016/j.sajb.2018.01.003en_US
dc.identifier.endpage118en_US
dc.identifier.issn0254-6299en_US
dc.identifier.issn1727-9321en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage112en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.sajb.2018.01.003
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38013
dc.identifier.volume120en_US
dc.identifier.wosWOS:000456314600012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofSouth African Journal of Botanyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectChamomileen_US
dc.subjectAutofermentationen_US
dc.subjectBiological activityen_US
dc.subjectEnzyme-inhibitionsen_US
dc.subjectNatural agentsen_US
dc.subjectDoğal ajanlar
dc.subjectEnzim inhibitörleri
dc.subjectBiyolojik aktivite
dc.subjectOtomatik fermantasyon
dc.subjectPapatya
dc.titleMultidirectional Approaches on Autofermented Chamomile Ligulate Flowers: Antioxidant, Antimicrobial, Cytotoxic and Enzyme Inhibitory Effectsen_US
dc.typeArticleen_US

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