Effects of Deferoxamine on Tissue Superoxide Dismutase and Glutathione Peroxidase Levels in Experimental Head Trauma

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dc.contributor.authorÜstün, Mehmet Erkan
dc.contributor.authorDuman, Ateş
dc.contributor.authorÖğün, Cemile Öztin
dc.contributor.authorSümer, Fatih
dc.contributor.authorGürbilek, Mehmet
dc.date.accessioned2020-03-26T16:37:06Z
dc.date.available2020-03-26T16:37:06Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description60th Annual Meeting of the American-Association-for-the-Surgery-of-Trauma -- OCT 11-15, 2000 -- SAN ANTONIO, TXen_US
dc.description.abstractBackground: This study aims to evaluate the effects of deferoxamine on tissue superoxide dismutase (SOD) and glutathione peroxidase (GPx) brain levels after head trauma. Methods: Thirty rabbits were divided equally into three groups: group 1 was the sham-operated group, group 2 suffered head trauma (no treatment was given), and group 3 received deferoxamine 50 mg/kg after the trauma. Head trauma was applied unilaterally. One hour after trauma, brain cortices were resected and SOD and GPx levels were determined. One-way analysis of variance and Tukey-HSD tests were used for analysis. Significance was defined asp < 0.05. Results: Baseline SOD levels are preserved in the traumatized side of the deferoxamine-treated group. Although GPx level of the traumatized side of the deferoxamine-treated group decreased significantly, the decrease was significantly less than the nontreated group. Conclusion: Trauma leads to a decrease in brain tissue SOD and GPx levels, Deferoxamine suppresses this decrease completely in SOD level and partially in GPx level when given after trauma.en_US
dc.description.sponsorshipAmer Assoc Surg Traumaen_US
dc.identifier.citationÜstün, M. E., Duman, A., Öğün, C. Ö., Sümer, F., Gürbilek, M., (2001). Effects of Deferoxamine on Tissue Superoxide Dismutase and Glutathione Peroxidase Levels in Experimental Head Trauma. Journal of Trauma-Injury Infection and Critical Care, 51(1), 22-25. Doi:10.1097/00005373-200107000-00004
dc.identifier.doi10.1097/00005373-200107000-00004en_US
dc.identifier.endpage25en_US
dc.identifier.issn0022-5282en_US
dc.identifier.issn1529-8809en_US
dc.identifier.issue1en_US
dc.identifier.pmid11468462en_US
dc.identifier.startpage22en_US
dc.identifier.urihttps://dx.doi.org/10.1097/00005373-200107000-00004
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17535
dc.identifier.volume51en_US
dc.identifier.wosWOS:000169905800005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÜstün, Mehmet Erkan
dc.institutionauthorDuman, Ateş
dc.institutionauthorÖğün, Cemile Öztin
dc.institutionauthorSümer, Fatih
dc.institutionauthorGürbilek, Mehmet
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofJournal of Trauma-Injury Infection and Critical Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDeferoxamineen_US
dc.subjectGlutathione Peroxidaseen_US
dc.subjectHead Traumaen_US
dc.subjectSuperoxide Dismutaseen_US
dc.titleEffects of Deferoxamine on Tissue Superoxide Dismutase and Glutathione Peroxidase Levels in Experimental Head Traumaen_US
dc.typeArticleen_US

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