Nicotinamide N-Methyltransferase expression in cervical adenocarcinoma and its clinical significance

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dc.authorid0000-0002-0466-140X
dc.contributor.authorAkar, Serra.
dc.contributor.authorHarmankaya, İsmail.
dc.contributor.authorUğraş, Serdar.
dc.contributor.authorÇintesun, Ersin.
dc.contributor.authorÇelik, Çetin.
dc.date.accessioned2020-03-26T20:15:28Z
dc.date.available2020-03-26T20:15:28Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroductionNicotinamide N-methyltransferase (NNMT) is a metabolic enzyme increasingly implicated in tumor progression and resistance to treatment. It is overexpressed in human cancers including glioblastoma, gastric, pancreatic, lung and colorectal cancers. The role of NNMT in cervical adenocarcinoma has not been studied thus far. We aimed to evaluate expression of NNMT in cervical adenocarcinoma and investigate its prognostic significance.MethodsNNMT expression was assayed in 18 cases of cervical adenocarcinoma and 19 cases of benign cervical tissue. NNMT immunoreactivity was scored by multiplying staining intensity with percentage of immunoreactive cells.ResultsThe expression of NNMT was significantly higher in cervical adenocarcinoma than in benign tissue (p=0.024). NNMT expression was significantly higher in patients with locally advanced than early cervical cancer (p=0.031). NNMT expression was higher in patients with tumor size greater than 4cm and in those with poorly differentiated tumors compared to patients with tumors of 4cm or less and well-moderate differentiation, respectively (p=0.044, p=0.014).ConclusionAlthough on a preliminary level, this is the first study to detect an overexpression of NNMT in cervical adenocarcinoma and an increased expression associated with advanced stage, increased tumor size and poor differentiation. NNMT has been shown to carry prognostic and therapeutic importance in a variety of cancers, and it can be a potential treatment target in cervical adenocarcinomas.en_US
dc.description.sponsorshipScientific Research Project Endorsement [18401023]en_US
dc.description.sponsorshipThis study was funded by the Scientific Research Project Endorsement (number 18401023).en_US
dc.identifier.citationAkar, S., Harmankaya, İ., Uğraş, S., Çintesun, E., Çelik, Ç. (2019). Nicotinamide N-Methyltransferase Expression in Cervical Adenocarcinoma and Its Clinical Significance. Indian Journal of Gynecologic Oncology, 17(3), 63.
dc.identifier.doi10.1007/s40944-019-0309-yen_US
dc.identifier.issn2363-8397en_US
dc.identifier.issn2363-8400en_US
dc.identifier.issue3en_US
dc.identifier.pmid#YOKen_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s40944-019-0309-y
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38038
dc.identifier.volume17en_US
dc.identifier.wosWOS:000477011900002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAkar, Serra.
dc.institutionauthorHarmankaya, İsmail.
dc.institutionauthorUğraş, Serdar.
dc.institutionauthorÇintesun, Ersin.
dc.institutionauthorÇelik, Çetin.
dc.language.isoenen_US
dc.publisherSPRINGER INDIAen_US
dc.relation.ispartofINDIAN JOURNAL OF GYNECOLOGIC ONCOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNicotinamide N-methyltransferaseen_US
dc.subjectCervical adenocarcinomaen_US
dc.subjectStageen_US
dc.subjectTumor sizeen_US
dc.subjectTumor gradeen_US
dc.titleNicotinamide N-Methyltransferase expression in cervical adenocarcinoma and its clinical significanceen_US
dc.typeArticleen_US

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