A comparative study of the in vitro enzyme inhibitory and antioxidant activities of Butea monosperma (Lam.) Taub. and Sesbania grandiflora (L.) Poiret from Pakistan: New sources of natural products for public health problems

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dc.contributor.authorBaessa, M.
dc.contributor.authorRodrigues, M. J.
dc.contributor.authorPereira, C.
dc.contributor.authorSantos, T.
dc.contributor.authorda Rosa Neng, N.
dc.contributor.authorNogueira, J. M. F.
dc.contributor.authorBarreira, L.
dc.date.accessioned2020-03-26T20:12:16Z
dc.date.available2020-03-26T20:12:16Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractInfusions, decoctions and tinctures were prepared from flowers of Butea monosperma (Lam.) Taub. and Sesbania grandiflora (L.) Poiret and evaluated for in vitro inhibition of enzymes implicated on the onset of neurological diseases (acetylcholinesterase: AChE and butyrylcholinesterase: BuChE), diabetes (alpha-glucosidase and alpha-amylase), obesity (lipase) and skin hyperpigmentation (tyrosinase). Extracts were also appraised for radical scavenging activity (RSA) on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals, and for metal chelating activity on copper and iron ions. Samples were evaluated for their total contents in different phenolics groups by spectrophotometric methods, for phenolic profile by high performance liquid chromatography e diode array detection (HPLC-DAD) and for mineral contents by microwave plasma-atomic emission spectrometry (MP-AE). Regarding B. monosperma, the tincture allowed for a moderate inhibition of AChE, the decoction was able to inhibit alpha-glucosidase and no activity was observed towards BuChE, alpha-amylase or lipase. All extracts had a low or moderate inhibition towards tyrosinase, and significant RSA and metal chelating potential. As for S. grandiflora, only the decoction inhibited AChE, none of the extracts was able to inhibit BuChE, all samples inhibited alpha-glucosidase and infusions and decoctions had similar inhibitory properties towards alpha-amylase. None of the extracts was active against lipase, but all were able to inhibit tyrosinase. Extracts had also significant RSA, moderate copper chelation and decoctions had the capacity to chelate iron. The most abundant macroelements in both species were potassium and calcium, while iron was the prevalent microelement, especially in B. monosperma. Both species had significant levels of phenolic compounds, and the main components in decoctions and infusions of B. monosperma were syringic and salicylic acids, while the major compound identified in tinctures was the flavonoid luteolin-7-O-glucoside. In S. grandiflora the most abundant were chlorogenic and neochlorogenic acids and catechin hydrate. Molecular docking studies on the most abundant molecules in S. grandiflora, (+)-catechin, chlorogenic acid and neochlorogenic acid, indicate that these compounds are able to dock to alpha-glucosidase in a similar manner than acarbose. Our results suggest that flowers of both species are a promising source of high value-added compounds with enzyme inhibitory and antioxidant properties. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipFoundation for Science and Technology (FCT)Portuguese Foundation for Science and Technology; Portuguese National Budget [CCMAR/Multi/04326]; FCT Investigator Programme [IF/00049/2012]; FCTPortuguese Foundation for Science and Technology [SFRH/BD/94407/2013, SFRH/BD/116604/2016]en_US
dc.description.sponsorshipWork supported by the Foundation for Science and Technology (FCT) and the Portuguese National Budget (CCMAR/Multi/04326 projects). Catarina Pereira and Maria Joao Rodrigues acknowledge FCT for the PhD grants SFRH/BD/94407/2013 and SFRH/BD/116604/2016, respectively. Luisa Custodio was supported by FCT Investigator Programme (IF/00049/2012).en_US
dc.identifier.doi10.1016/j.sajb.2018.04.006en_US
dc.identifier.endpage156en_US
dc.identifier.issn0254-6299en_US
dc.identifier.issn1727-9321en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage146en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.sajb.2018.04.006
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37398
dc.identifier.volume120en_US
dc.identifier.wosWOS:000456314600018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofSOUTH AFRICAN JOURNAL OF BOTANYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectTraditional medicineen_US
dc.subjectMedicinal plantsen_US
dc.subjectNeuroprotectionen_US
dc.subjectDiabetesen_US
dc.subjectOxidative stressen_US
dc.subjectMineralsen_US
dc.titleA comparative study of the in vitro enzyme inhibitory and antioxidant activities of Butea monosperma (Lam.) Taub. and Sesbania grandiflora (L.) Poiret from Pakistan: New sources of natural products for public health problemsen_US
dc.typeArticleen_US

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