The Effects of Sevoflurane, Desflurane and Propofol on the Percentages and Activation Molecules of the Lymphocytes: A Flow Cytometry Analysis of Bronchoalveolar Lavage Fluid

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dc.contributor.authorErol, Atilla
dc.contributor.authorReisli, Ruhiye
dc.contributor.authorReisli, İsmail
dc.contributor.authorOtelcioğlu, Şeref
dc.date.accessioned2020-03-26T18:16:54Z
dc.date.available2020-03-26T18:16:54Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: We aimed to investigate the effects of anesthesia with desflurane, sevoflurane or propofol on the cell surface markers and the activation molecules of the lymphocytes in bronchoalveolar lavage (BAL) fluid via flow cytometry. Material and Methods: Sixty patients were scheduled for elective surgery. The patients were divided into three groups (Group D=desflurane, Group S= sevoflurane, Group P= propofol). The same induction agents were used for all groups. The anesthesia was maintained with an inhalation agent (1-1,5 MAC) or propofol (the starting dose 12 mg.kg(-1) of propofol infusion was reduced to 9, 6 and then 3-6 mg.kg(-1)). BAL was performed immediately after induction of anesthesia and surgical procedure with a fiberoptic bronchoscop. Blood pressures, oxygen saturation, end-tidal CO(2) values and minimum alveolar concentration of agents were recorded. The percentages of the lymphocytes and their activation molecules were determined by flow cytometry in BAL samples. Results: The percentages of active cytotoxic T-cells (CD8(+)CD25(+).) and active B cells (CD19(+) HLA-D12(+)) decreased after desflurane anesthesia. The percentage of cytotoxic T-cells decreased after propofol anesthesia. The anesthesia with sevoflurane had no effect on the percentages and the activation molecules of the lymphocytes in the BAL fluid. Conclusion: This study showed that desflurane and propofol decreased either the percentages of the cell surface markers or the activation molecules of the lymphocytes during perioperative period in a tissue sample whereas the sevoflurane had no effect on these parameters. We conclude that sevoflurane has no effect on the lymphocytes in the BAL sample.en_US
dc.identifier.doi10.5336/medsci.2008-9364en_US
dc.identifier.endpage449en_US
dc.identifier.issn1300-0292en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage443en_US
dc.identifier.urihttps://dx.doi.org/10.5336/medsci.2008-9364
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26945
dc.identifier.volume31en_US
dc.identifier.wosWOS:000291330700025en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherORTADOGU AD PRES & PUBL COen_US
dc.relation.ispartofTURKIYE KLINIKLERI TIP BILIMLERI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBronchoalveolar lavage fluiden_US
dc.subjectdesfluraneen_US
dc.subjectsevofluraneen_US
dc.subjectpropofolen_US
dc.subjectflow cytometryen_US
dc.titleThe Effects of Sevoflurane, Desflurane and Propofol on the Percentages and Activation Molecules of the Lymphocytes: A Flow Cytometry Analysis of Bronchoalveolar Lavage Fluiden_US
dc.typeArticleen_US

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